{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022zjOEeI0HfREaKoN+TkiQU1c0VzancSWTqAoQ5uY3FH92HtRIoawQ447ms2TWLQC2+z\\\\\\\\\\\\\\\/tzxvX7JHsKRriBdoNc0zEkajMoeQV2chdXtu9OkaORKrp8dzqMtj9mNna52oxaXf4q76tvpD1ttxGCPYu+j+p1LN0YUmzRkgQZTjVEZNiREPV8O9ioRbcfbui9l\\\\\\\\\\\\\\\/eStPmmTCkDBNV\\\\\\\\\\\\\\\/v\\\\\\\\\\\\\\\/YMhUEfJhp007oWVOiCpnOuSYmKDfZsNeBEoLz+gt3AbHn94ZCSw7ZHk5s4cX8n3noPf1YP4NUs0r8s2iltJIoN2oT1KI7oYPYV3yL7TonmBLOKljrVKk1rFh9sbjDXQsXzQg\\\\\\\\\\\\\\\/KQZGWu0hr31rzkKUhDCUew0eVu8u3ur1b7Nj4cTauRzIPo4eP9b6wrTNbjV+kMPTmAGFlmxWdotCO9FgTL\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/20iMfssKdif+zA4TquWmHzdLudlKbkrQtHR1pTNuz0BW8Wv0TLUfrhgIcIPa6QsURWCFIKDlcBBkBllE7PL5GUK4feckfq5ovXEdzrl+D\\\\\\\\\\\\\\\/wVxjYlvostC7sYahT35ggBn18idxcyjBL1uL\\\\\\\\\\\\\\\/udcNyOAoSLS2KOQhKof3NJDBBhANn+\\\\\\\\\\\\\\\/WbbuCOUhNx26iPnRqi\\\\\\\\\\\\\\\/MyJgRhYn7AkTklBR\\\\\\\\\\\\\\\/PWTB1l6axHY7Z9DkQHKoX7RoujTZ2pVNGw6IY2yZJ3tF7ab5ki9xfPraJvNGGdiD\\\\\\\\\\\\\\\/cbTFQXzTcFC8gZzkYVhGK6Serk2mtAg6m6huG5djo7FS6ty9ud13zwuHCTtU3\\\\\\\\\\\\\\\/y+JIhMYJA3mcOKT2UXRacusA7QBx5rdgzxSRtuQG16VoPbKdoLBHxuFYIKPPH52H4gPBJHDZ2Xl32PhFbkdYdV4a78K5a7fjRwLiPU0K8ahYJHs9r5YIbOa+K2ImNpTPgAvPoJ\\\\\\\\\\\\\\\/F5Hr29nsmmNkShmxWq5F0VXWSorkaSl\\\\\\\\\\\\\\\/k2DQNrdZQd3cK\\\\\\\\\\\\\\\/ZVUYccak+sXlw1sSIR75J8ayaxGqFBEhoa+6hZ3ROSEOQyKka2N0rmrkLbXZBTX6AyqQ4LG9gn7ykNvoyOUd0+eVbNTzhVlG6pVJTYVrAFHzHNFWtdQNljzLGWEZC7UYtZCc9690AbRQgY2EHBCQFEj\\\\\\\\\\\\\\\/ZHqc3ws\\\\\\\\\\\\\\\/SlkB\\\\\\\\\\\\\\\/eXQP3sZ\\\\\\\\\\\\\\\/8V7bRJEXwxRuUSaIYmGOvjhLJ2swIa2MkJz1CAJKhYSMEcidmNz1yr5FGO4TIj2XRl9idevrFcyKOE+wUjR3pzIntV3\\\\\\\\\\\\\\\/1Y48EtoVuCrE\\\\\\\\\\\\\\\/B1LcuHyeIMbujgvejgz1Fvq1yiUTGC25rJ7YI0IxrRtoz01zaowKpahmxs9NIOGMuQ32BixQahBG9i87Gc06hWeOpSYhLa0jHsO7UnZeb7rIuWXtfKR4H5SrioUKCTkuvFkGZBuJCpaQlJAHJanezMj0dqgb9m\\\\\\\\\\\\\\\/hFSdYf6zVSEjoyIvJtbBSG363TlrHtTc1r59Spu1Q1v6H2IRFN9R5f+lMxMEyXBV9jb5W2DvpUIMZGW+SWFCuqfg+20vpHr1C+tXWga7jrqVw7afEkPCnyMMG\\\\\\\\\\\\\\\/G39n8fuWO0xlG6gsjL\\\\\\\\\\\\\\\/iZVGNZqh\\\\\\\\\\\\\\\/yPpIApzGrM67ndJms0MHbtANdRGHvHomatY8XiiWK7hqokghd3zNBJTJ7v2McUn1ph3LHWg2TzX+ZC0Qsz4Kd0+3pgn\\\\\\\\\\\\\\\/3ojPKga20JaT3vIq2M9IA1JSZeVEAoKCIdmO57BFbeC0ulgPAO6j+KvNAceZN5JY5NZylAK0nLTW7EDjlm52ICu+BqEbM3IS7eCfTtPmHrjuOHzNl8ucqlCHz0QijNczHzHfnSbQvMRRVkOr4dGu192AdPNH3Ai3mZvMN++E+CmGDGQ\\\\\\\\\\\\\\\/xsfnSVsDkGwDxVfgO4n4su5yJffhOlkkUoqG4vJ4cMdpGH\\\\\\\\\\\\\\\/HNyHrUbORibN+Q2Z12nXvnB4VhsjycFzw+uLUib2IN0ZI+qpQ+b1IdNBO5Zi6mNj5AHekffpfYPhxcS\\\\\\\\\\\\\\\/EwpswQSN7H6ggRmHDoEBdpU\\\\\\\\\\\\\\\/pLew7Lev5GnOuvTv\\\\\\\\\\\\\\\/Z4dBAWVctlY5i1vJaMwpLKZQ\\\\\\\\\\\\\\\/+zV+7DT1FoLuVne5torqfy\\\\\\\\\\\\\\\/6ONIZ6zCshSTMzuDjE3eeotbApDQDspW3eQkRjXtiR\\\\\\\\\\\\\\\/L9kNRzluGwxkIXnquYDksOmwKEftTrG4PoCDP3YFuzhXF1PtHSQENkbPHobT2SGjnA5zIAeJaXubMQiTRXh28MizjttJaVaKoou4R2yNwBMbWer90FDk2+HFkNk3V9B38tFuPnAdhbroOqxyuKWZwmr2Ks4LE8fjSLFWYci7ilttuSuV9MVn6HaZOl99TYHjEWVioE2R1EtL264GKat7L8GR0lU6yKt5SNltDksV0ouV9aHaHDkYDRsRwjeyc+\\\\\\\\\\\\\\\/FMjyJr0faSB7AsppzH2Vl6H1g4\\\\\\\\\\\\\\\/jok6WnQerWAWgCA8Z60c\\\\\\\\\\\\\\\/UOkMr\\\\\\\\\\\\\\\/PmtbiIrm7knc+jtJkYQ\\\\\\\\\\\\\\\/wUNcErIibZKN\\\\\\\\\\\\\\\/pNiHVXS1ErvrpbvJweAvsGaLjR0xCMA3Y57YgjoRHlyv+VlwsO3b\\\\\\\\\\\\\\\/upkuKEXexEot0YqNDx9vUwWjTEfxsRk9K3XPvKnlyRsaBunr\\\\\\\\\\\\\\\/zm+i\\\\\\\\\\\\\\\/EGz0md9AViMq4q5n7c12KxAH8LBBzGsgNN8CsyZf9qH92a\\\\\\\\\\\\\\\/DguEUBUdoQPIE\\\\\\\\\\\\\\\/qmN03s1yojsiGloSXp2SjFnxQ5WoQUJFuUNs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022S++sJbv9GuRdCzCLJDfxYg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224ccf61ad29afb4dfe5be1aa0c2544ea3f437bd5341c3e930ade881c18769b670\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/4\\\/e008125.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/4\\\/e008125.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008125\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008125\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008125\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}