{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00228VJ5hg6J53sPQKvOwcOBXG32YmQg3D2oogniHCCAZgNHwsfznDBvNatZ1m8DVe8du0asLPUMW8j\\\\\\\\\\\\\\\/ikZbKLz0u8IdKWn\\\\\\\\\\\\\\\/x3\\\\\\\\\\\\\\\/hUWTlleWBzq\\\\\\\\\\\\\\\/l95N6O+YwMQSzm1goWyEPoeaQD2UDJWPRHbA8D84STfp0D6JHi9vy5WQh5W9gESrtyzxZrc8Yr4VGey0TJ2H6jB6dlnQP\\\\\\\\\\\\\\\/PWUrEqzET1Q8Wx8UWBeEwRlVi+Ov4rFsvAtvq1I4C0qw3Rq1QT7bRLRwxtLteH8OBaZX4I7XvuY\\\\\\\\\\\\\\\/U1Oj7Bfz6fN68yDZvTX2tQsnfgPUFNh9YoWpepOZUwXTvrD4nDKdGe0vjG9j5GCCV5SPAphxycc26+oB\\\\\\\\\\\\\\\/PF0IXG8J\\\\\\\\\\\\\\\/w8Obg\\\\\\\\\\\\\\\/GiolaruSJ44c4ugQNP6O9nGS4dT3MEbFzOHlg6512xNkPV+YF0SRob13oew+RltCcU91RXBOAjYOv+18Trp7RX1MTxfzDrGwDFUIpicBM\\\\\\\\\\\\\\\/KtLWlV1j3PGSynBte7rcaHy0B6s3eJ1yigEOfu979b2wk0AR8FIcFDm4ATtrhOXZOtPMhmEQKEiRTfguld\\\\\\\\\\\\\\\/x3HcQABnljlC47Gv+Gckhi2gyNxCsirLJLmeyQ4QLbkJd0N\\\\\\\\\\\\\\\/VlErGpt2cU5f0ii5pI1vqTo5fNTw7M+90QpIn+MytEjw8Vz7g8kSWBdUIsr4rNl8I6X1fjYhjHsgMk0KmQdGT8AphSPPRkeU8fTxDoMubhACvPw5HyfB34STQJXnChi6buOrkzHjfeDi7hY6OcVNWJecLK+twr+Vz\\\\\\\\\\\\\\\/V9Q0C7aRbFtXw+v3evppXWasQRjrFns4CGX0daKdXbHwY3Aebst3X7DAg9ra9PkvE19Y9L2bOSBtCHhgBYZjfTNVwx3TtExq3WDky8etFPg7XR6qmEv+qX6DjxRadjbp2JG5qNnYTZ47QZRnVjExXVmeN\\\\\\\\\\\\\\\/LzNMFR85oF4g3FKctbgjp9No1osfoEc+aMykjHXEh8mIX4KrGd6BsPMWIqTIf01DSwqxrs7010CnBMy4l7bBvdhYHto4H5QzQLHKRPltLtfOxJuHqiRQoEt3tITpI442OXw+aAKRctr5yXoZuzD9fMGQmArZ5zLpSSdih+ENa7gPRFV+0C\\\\\\\\\\\\\\\/IWvHPtlxoSFsE9vwQljfYMQdMEyLE4VDtkdD30KGPxW094ueM27LjEHhYJbrA2IzX4ZMFbTiOinWvejxm0pkzU+bj\\\\\\\\\\\\\\\/mLkHomxklVw6v3O9x\\\\\\\\\\\\\\\/8XB61XBar+EsYWv\\\\\\\\\\\\\\\/GbKwwe7OPF7ietxJ58HTFvY74Ow5HtZFnPxyxJ6ggBexdOCGCoFTZB+8GGIPDJgGxajwJGCp6WUt+BpKAWjeaGwUHUVgp6cCf5plGeVLwdAL97EJeaDT3IlSTsng\\\\\\\\\\\\\\\/U6DpTqLefPyyKIXNivaEuXQJBl6F3w\\\\\\\\\\\\\\\/OZC6KQzpBODwuBSHd7roW03kGfRtsk3ns3F2dHZhh94MFyuVKiswv4Rh7APM+NloalYJ41ZhXYqW0e1koOvWp82P4zF7sWAt57Qu5wl5Z\\\\\\\\\\\\\\\/9yDULQ3aM+Tp0F3bL324bbeQuwM8aPgCipOziqItfVd23nDVyfMaikU+DMltjlxi+FxbwNixgke8l\\\\\\\\\\\\\\\/K\\\\\\\\\\\\\\\/Jh6zVZPIuO\\\\\\\\\\\\\\\/hvY9etbGYvGj95ieMHYyiGPKfhUuFbS5EQqsLUO4SQttSbkQrp21DFkNQKmKFjX2t3eiJxU\\\\\\\\\\\\\\\/HZ2+cfEqBsCkT0+43VrovkKw9V2Ew7rOxC9XTisUlrlAKIYC\\\\\\\\\\\\\\\/kVNGXovp7ryXE9qzmWyMcKPi3YLr8\\\\\\\\\\\\\\\/MP3K+MjlHbVfsKQf10e8BIR1ip9EplT8uTmvIXjaO0Knzh5LAdE5tEKGMYzhhkVYzBOenGpUUljytUQzaJtu4xXEgH506xmY4Yhx3GKuud2oxv6h+GoLXWr0J12cyw1qDvb9rkV5YGq5ydrIjkIWao2dj2cBP1to2iU7xPvorRT3GGcqKJl1UW0m719ah3i6P925p4cYSFAypag0kB4OroXSuMgJX7eoSjjUCY+MKzxsFnF8rBKJK4W3lm2hlaY3JP2glkxNfVom1Wq4+FumORzSD93e5C9gOkYcOxlSF7GWAhHNMfd9iFAXrS+SWEEkl3OdLW\\\\\\\\\\\\\\\/AI50t77AWs5p7WbyESu1FoYhdTG2ikMpPz\\\\\\\\\\\\\\\/7pSLeRoMnVh42mGHQozKXOyAjOx6usl0GKpTAdwVC3S0FFTz6Ulh3CWCD\\\\\\\\\\\\\\\/BINQ3E\\\\\\\\\\\\\\\/WWoPNh2h\\\\\\\\\\\\\\\/FjPv2y9XRZKciDYFo9OMbsQXdB+OI76zWsVv3ND4UBESr6glJLEtWtDIvkOtqWTgE7IGQ1njyjMWMu\\\\\\\\\\\\\\\/OAvDJoYa7qs3Y0PFoPRQuiBYDoVDSAxLcC95XQVPSbprdbudtTR8hrA2G9cN8VQ3EKY41n1n19YU+7s5MMa4Y0VOLMmt7iQCUqNOSahdLmmb0jSxiVg5ymr57Go0lYVWyazdAqSgH6T0Xi04rvr8+zCNx7bFmelZPexCsmqpKvifAOKmRklm7UokRGlnmrKKKPUQVsWGjBpiYBINkF\\\\\\\\\\\\\\\/luE5pe7Cf3rgVPVKKO3PSpph6b3yULQDGFApMmEcR0Vkk+0vZIboEpqlN4RMtL+gmNpNyP8xNQvBVSmQp8FB9Fec33ltSSN2iRq7lT822ZxRrZsnywOLZDuLCDRW2rnvARR\\\\\\\\\\\\\\\/gitZDSinV7UE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022n8mhrPey4RyV2AUCUq\\\\\\\\\\\\\\\/4mw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022021bdab9b3b921cf165d618d980e5e7cc9ff4033f07b083c94f7a47040e433a4\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/25.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/25.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0130-4\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0130-4\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0130-4\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}