{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022TJF0zqzmCZa2X\\\\\\\\\\\\\\\/1XLbPBMzWGTOyb+JDgoyYrV\\\\\\\\\\\\\\\/Po75KG2hz5QxfDE77Yr\\\\\\\\\\\\\\\/h4D\\\\\\\\\\\\\\\/5RHGYx2aZc9GcNMdWlQ00zDGn9r2Fxupzy+ZWJwwY5QsRGKpDv+zBC5cft+1Zgvo8j7Ym2BVqPPPxOfBy+3EkhplqWvNMxZTmZWYco2zW9WPl21W+U\\\\\\\\\\\\\\\/FoW8eejhIxzKa\\\\\\\\\\\\\\\/OfSbfhKPH2GUEj8hmbcMolSlkitr+Um9pFdFA\\\\\\\\\\\\\\\/kEbKOXwCabXqggj1lUJpJugQ1hovtSLtEESkpZ4+rLnyvl4h6Kn2VrcLh68QJljwmNxJZj2OPLdyYTtZSoAM\\\\\\\\\\\\\\\/+z9v791wm1\\\\\\\\\\\\\\\/IuKonkmaJS4Gg11o3rBTqdEKxczRhMQQ5Vp1VYzu0sL4Lf\\\\\\\\\\\\\\\/xuSBs0ZA+mkFCLfx8lPKXKxukE4fMKInrvc7XuoO+dT0w30qUuuvqwd5M+pKa2WwU+7yuO\\\\\\\\\\\\\\\/pJVwj6tVQ75lSJNOracZQi7pb25iN7lE08q6UwJGy\\\\\\\\\\\\\\\/4PNXdAfaBBbpD1ltP8\\\\\\\\\\\\\\\/akKka8Hz4UEhC39phf+9E0F7DnXJXwUJcBgSaMPnLXGs9rVhBTEdC2cJLDhweTDjKj9tRwnMWuiqE2Ks6rqpZQ9LlewjmQ38Q9XeJKgxhuuvzGgc4J5bTbqZzNQzv8zKFFAnXdB8REvmJoorbmSWhxWQvek\\\\\\\\\\\\\\\/EBE8t+OasJ5imtWFM1VoBoMdpxRA1cxy1wgPUeprIoWmcpgfYuOdzeBABKjFBHX2ggpZhNy46j19wfVzGoJnOjEtNJfIFi9tqR883gzoTl9\\\\\\\\\\\\\\\/iDZ3HQ5H0trQjXvgeuK3WtKsHiqFuDBDlw+Al2QlB\\\\\\\\\\\\\\\/+4vyhxx8eGAaeMjVmBO0yGq\\\\\\\\\\\\\\\/TUo2YP4Bb6T3uxxADu9JMq4byTm0It0NmRH52u1YYxTH+3P+gqgS7aGGpRHibDVmHVFVjFywE+RHrFa7is8tWdMPFr3\\\\\\\\\\\\\\\/Qdin0emjv0em5RjUA1NtcrbZzeqdvAcTfU\\\\\\\\\\\\\\\/hwFPLa5bcjxtgEyRnfcKqmd5D41tVuK9cbi1BmSoDxIpu77BdV\\\\\\\\\\\\\\\/4vdwi3ax6FtilgiDWrqJqOd98ovbA8RqDVnw8tlzgbu7iQNmEUyuenoRzN5hRgXnq2DDMzfUsCTl2iPwzsMWIO+RaMBiJ59Rl8yu9HbaIiXfhhcdcmlkK9TNwSZo3O6YgIcSd8RNGt2eooBdhjvasfnm87QYEBZmYNfY9mbVRXPWJpFtGYwz9Vg27A14OHbGoA\\\\\\\\\\\\\\\/7abB2mAVDsGOv6v7545c8gjzWoJ9EBAOaG4x\\\\\\\\\\\\\\\/MxZSksAe3w6Hw7xBliqNPC4D0OHINYWdhssoRVSKa7elOhtZg2nnvdLAQC6R5e1C+NaiEQwF3xIsK0Tup1Dr+ccHhmDa6YBoTnPl6YVYFMhD5w7giJSunFnWQzuE5iIvv6Z+qKMw7c1Z2C+SE9Ab9HRZgYOP7pVxN3D84sNimG7KUCfE\\\\\\\\\\\\\\\/JYNYxzzPM8erxuFJ6l0bIfsLN\\\\\\\\\\\\\\\/9IzmDRZnUtAO1QqUs+VZ03Zv78sH3jjRMoK1yw1ysEoR97GLp1Km59CxCdUUCU0Z4NaRLFiZw24o1XT2C13pRIJnnxjC3FaDzN65W9pv0Agq5bvkcJ+f5uuH2qm7nhcgmQhQdIV\\\\\\\\\\\\\\\/64v\\\\\\\\\\\\\\\/+6Fo\\\\\\\\\\\\\\\/kxByCwZ8E1e\\\\\\\\\\\\\\\/64JkCRD4Wz89ycZw22I9jFOPol8\\\\\\\\\\\\\\\/lpCSeHYnvftTtt1yfJvQkiEECAgUQeUVuHK\\\\\\\\\\\\\\\/p3uVsMptlmXha0wmv+KalQX\\\\\\\\\\\\\\\/fX2yKOKhbNA\\\\\\\\\\\\\\\/gSnX6jMv5XBnkb34m6AB5lfZ7RgPQ4vkTLJbF6rAl+HNWMik\\\\\\\\\\\\\\\/AwJqN84irPpvqN\\\\\\\\\\\\\\\/zt+nEUNVvMPLgQOr\\\\\\\\\\\\\\\/UhylfCtAlmMUoKvRZ2EY3JMhoAZFejm\\\\\\\\\\\\\\\/rsaWlrUTAsujmAFBbWtUD3cdmRmzOjwKUui\\\\\\\\\\\\\\\/jOGNIsy23iSQtAmfvh\\\\\\\\\\\\\\\/S1wdfNiNbFSblA9Hgb7Galx1KvtHSY3yGyROoHVgseojqRPk1iEY+1JEFbY\\\\\\\\\\\\\\\/h8+dPrK9vBoPaJ46vLJqZilmSepXeWvynQFo3GPN7lJ9\\\\\\\\\\\\\\\/I6OV9U6shD16E6FNFxVKfmDpOsGGzXRBAI4cU4EHM58424335yWaghjAFixzlfrIVnqbC43PPE5BDwMsfP7FeBEQeQ+JaN+IIZHboxFD+X1huIODC0lWPaJmr11jGXxL9we3vqTr2hpDud0OuHzpU31lx2F\\\\\\\\\\\\\\\/AbXzFGqXD04ywush+U8bqHdXvnXiY1+h4ne9q24\\\\\\\\\\\\\\\/NFl\\\\\\\\\\\\\\\/hksZThYNaAnNrxEhqEe9yqML3naNbhACJPcLAYoQKAinNh\\\\\\\\\\\\\\\/pHo3FHZ7LUb\\\\\\\\\\\\\\\/kXZu\\\\\\\\\\\\\\\/1zrgdOBAfbYR1uV+U0dl1teWl1qJsZAu\\\\\\\\\\\\\\\/fqoFo+tGXnF72UZnrNcov6W9JimGpTNl4tQMLalaGCi9OLZmieKxGy8agcvpCYICXu6I7uh5O\\\\\\\\\\\\\\\/bj1ui00FB4YstxA0quWIsSEnFj1NHYbZQ57IYbTD7pTJ+\\\\\\\\\\\\\\\/EuN96JVuCiq8Z1ItdQLsW9SL2I9pzNaHqDjdqOZSVqTYLSeoX0WCuV8dtRe6mJ3p0iMrVLdttIcid+1RnAMKHQjC7\\\\\\\\\\\\\\\/LljnF+0g4pld3pKKwV2diLiHcLUdIzsJv08Hcw7OsOym9PZNcgpcqOiLNjmgUQLEZAFlphmg+atQY1WcyZHyosCqI4NwTmadgRNbhNGYcSC4EDjGtVRWyA8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022xKO5FpD4gSOykp2q3ysEBQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d98fac1ae0bbe8e1f624cee0829d45a5eaec2265ce492240fb6f44c7bd42c507\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/4\\\/e008628.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/4\\\/e008628.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008628\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008628\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008628\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}