{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00225OM5B41Wj\\\\\\\\\\\\\\\/DrElzhPgmi\\\\\\\\\\\\\\\/Gjm5\\\\\\\\\\\\\\\/FHt0S95yqygk07vaF2czbeMIGywlxQDqW6HR1TVa2KdXLsyHxvUAzktgQqe7\\\\\\\\\\\\\\\/ECMh+LI153BNPXGncv6suEiCH71oTFsSrr6lA4Nw+1Yukf\\\\\\\\\\\\\\\/cKP3uT93wxznc\\\\\\\\\\\\\\\/Fo9v0jfrrEcihMEFAFk03uU2+feZ7UjWfe4hec7wN5lGy3ec36hznOhczAhpWIuHU1wgvl25SVMQyMDhKwmf8NxvtdAcp25peBYFWWawaXqbWV+bATWhzRO2hcuFx+yEnEkNw06b7rfklX1tg4nvqPwxRSIBEPBT6i803lIL2JGYEUTJVnFigqrT4OqhxInyPWYU47TqIjysf3lPhbMZz4dzTFqp\\\\\\\\\\\\\\\/r67FrkqGyOxuAqk6YnfYmR9\\\\\\\\\\\\\\\/8BxLDuMhpu5cVy\\\\\\\\\\\\\\\/f1bo1fNf6j\\\\\\\\\\\\\\\/9\\\\\\\\\\\\\\\/4Se8ZIrtl8nlOnUBWjZlGfSK3nGUpc7wCiPUkNm5hJgiolmi5FvkIoJMbfGK00bXFtoz3F\\\\\\\\\\\\\\\/n\\\\\\\\\\\\\\\/VQkeLtf\\\\\\\\\\\\\\\/Tn1zJQxS54ya0gVhpbd0jBds8z\\\\\\\\\\\\\\\/LaRBZNEXcAupdHN8+G9Y9eqQOE60kxMG6iFbb8ox6ddxj2qm4eTMvqEkY6abzC4KCZ2lxK2PM9DEwZzNedO8KSLm4tpvRnXHaQxiCHhjCk0lI1XphRSTg3XI4+Lny81E2KVlGj0NCGjYk2Qg1JMz3WH4Zi44w9ZU5qVIzMZxMFd\\\\\\\\\\\\\\\/855BXZ9A7cRFQSSU72123UPBmFTodhWgjBIf8Gllw6GsR1FP5nFBdUJWaAGT\\\\\\\\\\\\\\\/RTNaOSSVLWh183mDeNDAZhZg27iUDcCGsrfKtuXSLlTDMvqIEpcTIh4IWw5M531\\\\\\\\\\\\\\\/NB1AZSBk4Xh7G2qu7ctLRTddzB4w\\\\\\\\\\\\\\\/ztTfKyiaT39GuxSsB6xZCR4kDUltSxnhhau1lP3gxiMSUXpK+tEoWi117OcJ\\\\\\\\\\\\\\\/BVNcYpOhkQKT8xZZCATmbcXI5Hj6wCl8YmKRAFc1yXHTYlhgihvVAGobhLHVmp5KwX6e69rmeHNpni8Dsj20r0NsxRHjN1aBbI6te1X5ffBjNH8RXEydSQNmlvhr5qL7fT4LOv67qZg2uUwaiUa2RNsNU1nKI0Wu64JfomuPwjgZZQxunANcxQjxhvga6UOdRm9de+Ey00mYs4cYFP9kAxvYycq\\\\\\\\\\\\\\\/N89Qo2cqo030+irkMuqfonuL4FWEPMAmSpDnrs5OgBk8mn50NBpB0bqBHqNVO9DQve4kHLKlKD847pPBosgh435zU5Etf47ic7ATx2LvuzSQymmCsuclxleVqRvnORJ\\\\\\\\\\\\\\\/luIbQQfkphudJzRDliThbbRK7tdGo\\\\\\\\\\\\\\\/AxndWAHRs4wKo26uLZuIjwGzsFiBt+iXFhJ\\\\\\\\\\\\\\\/eekYVhbEPwOdKL6OvbfLggw6L1QB35PwVVqtfSJg1VTTTuZwCRbQNRXXg5kJoP76iiUjgiYjQuZ2YZ9sgxYhvZWG++F5Ecv6d2\\\\\\\\\\\\\\\/plsNYQVuoYQ4DY\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Xj6YA7Nzc\\\\\\\\\\\\\\\/6Py9sb9\\\\\\\\\\\\\\\/xvVnkJldjuOuV7k9U9LVLi1bhmZUcQ0ZSNW1jMYN0QrmqG0U4SfUxteFgTIDYFxqn6XUWP3dJfrzswyBhRHCD6fQpsSdsWIP6zvpyoHWDfjm4injWrxyoeIZ5HSVhzya4\\\\\\\\\\\\\\\/lsJ0qBxrRoPhpqmZdx+vYpig2UWR1uUQGmdkkGrfk+b2VxOmVy6rsZ0YrCB744jY+BPmquqe4qA9XjHQnXXcsub4b6bV01po7KJwzJXxyjDLo+SOwzaHQ6eT5YHqmaworFogMINstw9ustNe\\\\\\\\\\\\\\\/I2I73AtU62opjr0SE3hoHmmSPnEm8Pguee04rMb0uOdvIkmjrMYoeEtBSkBdmp70+qTX+i6AO\\\\\\\\\\\\\\\/t0KFVKSNpfR2eBthwRi+yuGpA3H8tJnhJQzCHeofbuUXYAISTblMYDSB22vxYJZO3ncwGaFonNmzrbAxk8vhfS2AjNDaHBXEYucWTwSxwbt31y\\\\\\\\\\\\\\\/iTCgYG+vPQLN\\\\\\\\\\\\\\\/Ln7PrHUmHZuOKgw7ZSw\\\\\\\\\\\\\\\/1919fIc\\\\\\\\\\\\\\\/0Jy411rQoI0D6Z\\\\\\\\\\\\\\\/AH83BwH5KcQ8THMDBFGh5I76pfkWI5zcdrWMj42ZylV8kTs8H+ka1vc2Ogtk96IPqEC3X14p4ABsnqdwT2PG+53AUywzU+N8deihJOiqpJA0a+gOZn0RloI3Epj8dnwd03KAl58d4uBfXLykrTis7DXnE29H\\\\\\\\\\\\\\\/uvoV6bxyPZTZy0d3fBxNvOwY0\\\\\\\\\\\\\\\/y4beDqVzQrHHk7oAz+6FLkPNnng5VI8Cv91g0\\\\\\\\\\\\\\\/0OEosrsz\\\\\\\\\\\\\\\/kseuLYkPBclXCGfVzpsIEndvaVuOkM7o68x+ZcrJmXyzz3lCuqdsAAc\\\\\\\\\\\\\\\/0kXAPMK3hl7vO0Usep4DKO9fslr7F7TIy6vOiUF83RhT1GQBbZajg\\\\\\\\\\\\\\\/4aAc4yk4mQqoTI\\\\\\\\\\\\\\\/LaO32QTlY8oXnDiQL02aBUM6d1Awv8Q\\\\\\\\\\\\\\\/0gRx0D\\\\\\\\\\\\\\\/VfYvvydYo+cRiRzRtSfbqO5xJUlup58tDVJuoXJzyQn0zVzIO9D3n7N\\\\\\\\\\\\\\\/W+l3reBno\\\\\\\\\\\\\\\/YkO+Wo9Xt\\\\\\\\\\\\\\\/cmohsdV7+u0cGBcc2ctfD5K3rujUrbMMxMsavHaZg60z8QjdHoqylCqcAyAJ2X\\\\\\\\\\\\\\\/KSCi7zxxJM2epwk2ngPJ68ZysT1U8VnFzWMdb1a7MaqggaMWyxKhGPFJQdHZumwNn9bX2vl90L4wCfnehhMjNNfDjq0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022J0F0bUcdz7ipDDraIy4D7A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e1967ae8c0f68fba26e0b3c5ab49dd33920e4b7ffff5997ce7c3e9dfd9dba684\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/3.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/3.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0107-3\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0107-3\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0107-3\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}