{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022KZtCKdnbrW3yCcgcv92Y4d2y0JIbHNRhKvkUNK+gzNN4YHqYAQdawUN8+7YpKd4QJKsBaOuvZSfQ10MR4POol\\\\\\\\\\\\\\\/RXPIiX8GfcZuOmgJ1xNfvaNb4bQZJFuWCsCYWZVFgwtBaZz7ph9oYmHpTkT13VQUIpAOGtZY3CQL6ZGYNQYhWP54WfdqfcsgG+1RL4t4bQwkoG97zcGilakVOP9oNjdWiCY+Fk+Y5I\\\\\\\\\\\\\\\/vAdd7reyFzxz8BXIXoaul2F0WXxJxdAgJw4NcdTMgzNd\\\\\\\\\\\\\\\/86pHXhRzCLM8pm9VS51\\\\\\\\\\\\\\\/NTnmkNlEyS5iwjNAn6\\\\\\\\\\\\\\\/QNCVjonUGH\\\\\\\\\\\\\\\/Q0g4qG1pJQwoDouVrdaE+9dsx\\\\\\\\\\\\\\\/JBirepcvCfuRCDe\\\\\\\\\\\\\\\/zBNvNbWRPAoWszWNsNaXFOKxY1kKdJhwN6VTAuobNDwmA2OGnVMF5qsM7XSe2tn4+4jI5C0cymUflPZeAzu1beESA8acF1NlB3dJv7tn4myA1Rq76eRfzeZ5poNd+l0Ig1QSHSSYC1g4Mp4rcJXT4G+IhVH4NecBOUX59cO5GapOIJzW+SnPCk+Z+4N6z7K5xkr55+h94V8S9AgPn3ehfoLwoHDZoTrgE8h17GK4a\\\\\\\\\\\\\\\/3K7OEqPbAf6X1cfehv8wGx4goEuS\\\\\\\\\\\\\\\/KQibMdUy5exYQ8mSA5EZOWdU2mKegBxYfWwNOFGlN8SNIglaCmc2IzeaI63bjHe8\\\\\\\\\\\\\\\/e7ni86eLWne8t3epwG3i+IB+IO8v31vxkJdQSn+hf\\\\\\\\\\\\\\\/NquOU5WEQRcI8uJkeYdWZ6Z1MfjalTcvFtWB3\\\\\\\\\\\\\\\/ajdfSCRa0\\\\\\\\\\\\\\\/PbHYUeUOaqynV+xjhECmTZye\\\\\\\\\\\\\\\/vcfRQvsO+I5q0Nmj5PIo\\\\\\\\\\\\\\\/fwfccyMa\\\\\\\\\\\\\\\/Il0TeYPByIhjzzUJDee+uH9a8+2F+Ac3t+xLeArfhFM1uo4f3+QkDQNSXXct+qvI4rmATWICyQNNS\\\\\\\\\\\\\\\/IbY3XIY2eSPjSsofmPSHOBdz9vJVo+mF\\\\\\\\\\\\\\\/6mzxGqvQtVqoGmzuZ7XbvACs5K7eKL3UP\\\\\\\\\\\\\\\/cK6\\\\\\\\\\\\\\\/BW85BFPn62IqDNtwJ7Bx9BYAeG8Dre5Ooh6cDFvylEugS7vHKtPzr3XEC2ctkGxK+8\\\\\\\\\\\\\\\/kq9cLea3NIYakdTcq4HE+MVMr+vRN0aP49Oi0OmdCovq5JFV\\\\\\\\\\\\\\\/5GEam7yWujd14vvPbEtNwyamEY4x8x523vENg7KBugJ6DjauCRNjXev8h9AFeXNa+D2Gi7\\\\\\\\\\\\\\\/e6zuyCGewVs5rv1QMXf0yvdjszC4hTwuV4T3yg0kPjo6CYzOcJDRshTCvM4UNCkq9GKewnXjd2jPeDfrBekhSPIutCnSNQCQmm+uLkmNc+MOf\\\\\\\\\\\\\\\/k2icVRcJ0X9N\\\\\\\\\\\\\\\/wrO0+vcecLfXRBGe9Ahp6d0luXs9oTjO99lAZ1C\\\\\\\\\\\\\\\/LnvYbD70AX+hB5Tc5sGQIt2q2ND4opyd7RlIV6kneC4NBgzfiRcDA0rQV9tE0FSS8GWaVaG96VGFy1NWn8FCU2gzOv5Ol8Y08NwqXfSIONxJHxa0LXunqM8r0HcNHA+15kQXbDYLl5sG7Fdu3Je20OmmM4nH2Lm0wlP2UpeITkqn+Q5dwdOJR4VonfARhrFQb8kzKybtEThH5sBN0a2SJvxedl4nzBuVUqVOInsrABq3njg2sZN2qpAUdR0IEBtoIn6FiJI4gDyOGNqxqB4MrjTBJed4OeQkQ5HXCtwL5m60hKVMkcg1A2m\\\\\\\\\\\\\\\/TWfD226ff8YchryUfyLfVDUjNfJm5MK6Tw1Z5r2auovEWBPK+P2mkz+8UciXrybGyRl9IFcXeZao8\\\\\\\\\\\\\\\/jOSyZTFZXm8kgtavqW9DPA1bVHhZtQH0El5JnFd7OfZJnQSHI5ZRINdQ3NpanAeShw0lkM1dx7uBiAq8SC3WIfwx+b91kbVVaxixXrMYXWZRtMI2OKsammTlCD0ckCuNwwRFQjPSfhZg4zun7l0riawHcD1ujc48l\\\\\\\\\\\\\\\/10dUjCz97i6RXQFTJ7BgrxS1jbG64GvKEQKg+FV9FtcWTgRiETjyAWvMQYDobiYTQ08VSgBe\\\\\\\\\\\\\\\/qfTYczT8296z7FOZHT2JQ3unXCIFoh5ZlmBFwRfG4GIFZ9HzeUHe0YY4IPalhBHK53aug4uO7dHobA5Bjxt1hPhIiacxao9\\\\\\\\\\\\\\\/DkIgX2lE6Dy8dhktS6v+UJTPGpxdSrpzQaRrQuzSdcKKNkKrWHAfYhgaTTHP\\\\\\\\\\\\\\\/lsQXJe06oRM1w1gar0QzmdU4ORDCJi85dvdlIXQrBc7wKVXJF0HPVsZjinmWX42XFFEO02QpcFiJpDLCHRiGaPbZ7eWmlGtoTfHVjLcNKG1yfDPr0KEM2+LqPcCiehoSIYbFlq6hsyGw2+PcU1rJ8\\\\\\\\\\\\\\\/3OaCOjM60Ywrcf45JyjpPbQhHdNpMdSyKrWVlHS6kT6ibP\\\\\\\\\\\\\\\/f\\\\\\\\\\\\\\\/2xgeY\\\\\\\\\\\\\\\/AHFbIY+W\\\\\\\\\\\\\\\/FiYFrYbzz\\\\\\\\\\\\\\\/KCmIrb+rAiJ4ARQf9\\\\\\\\\\\\\\\/5YiW9tSV5sZCzX\\\\\\\\\\\\\\\/5HtwvkAYQBACKoF47TSznPA6W4nTHPIeTU07m+59K+fHRS4yPLZAKNBOkL4eI4rnvvdZc9om61tg61PLJyavRuvvIBmvW3mSsGW0EJdeSCABKHaiqfQnJ9\\\\\\\\\\\\\\\/DFo9CFlK9RPcte7enm8N+gnTvqOryRc5X+VhVYvpSdcFiU\\\\\\\\\\\\\\\/Vvl0fbX5AuPedzX2tQSn135uki1dQ5Yx+GhlOZECaIbr0k7R8CSwBNNEZqdjNVf4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022NdPuFXrQdsfvhuNU+RT4Yg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e4e0bf15714d394cd468783a6f4cca15f864e30e9d9946d0f33b2f17c7e74fd2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/4\\\/e008286.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/4\\\/e008286.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008286\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008286\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008286\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}