{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022cgTRSRUGHWuKC2NUdYGq1wgGAHxdAtt5\\\\\\\\\\\\\\\/zbnBpfjf0f8\\\\\\\\\\\\\\\/RJ\\\\\\\\\\\\\\\/U9oDE0A16SU5aFyclRSbsShmOGZII3xLWXq4CnXP8+fkb+FkLIvp4FYOe5yH4sii0\\\\\\\\\\\\\\\/NJEtlk7alP7SjLWrS8caMDXAMyDwkDM6TB+VTA9hsLVWDxgJ0Jn6RhtrcdBW4jLDi+WW5\\\\\\\\\\\\\\\/eoBs07p7z21er7WEdF5UqX1MUKb6PZeJHj8QDlslsVVf3dnQcxTbgEj1+qBTRCZ2a4toywP0NXwooX\\\\\\\\\\\\\\\/zFvBLeGT3BKJypCXMYMcwIjik3CVO2AVfcdVfTbk3trRNYWEfZRoiPPg7ah2jfGMEuRrrzp1\\\\\\\\\\\\\\\/ay21RjT7yYfmcAsDSh\\\\\\\\\\\\\\\/ZnlcpQceUVmEtZvIrLFHFhs36v\\\\\\\\\\\\\\\/QRNwhe5haatLVpsflhH0oobuycMlji2IKSCozd9OGmDwWhU4sh\\\\\\\\\\\\\\\/2itMcZ1iwx+\\\\\\\\\\\\\\\/5AGBe9NfmzZ6alB3TC1K8HrTq01AgbQ9Jwj3bA0TBz4xi5f4XDF+ycLYyBPLcnEpopoyqdr5roPFpIN+juacjAz25TIT+ENtaAeSu1g2S1fF8qgI6AnkEOnli4RK1bFvma09D6Hhrpgv44AiGkY6lrBpMOFYbmThRL5nt5yibFznEc2RCkzkx0i6tqAR7v2\\\\\\\\\\\\\\\/YkXLx\\\\\\\\\\\\\\\/MlToljGglp\\\\\\\\\\\\\\\/Ad11PAF2TNAnr2sE23Z3nVuRhV\\\\\\\\\\\\\\\/qkFVXGoCtA1IWtRYAYG4vIuNJqTK8xJrbpfqS0GVJLBy3sDJqgOyai\\\\\\\\\\\\\\\/FIXZ5aQ9aBnYhmR85EXoaWMECqQHGHb46ol+Jr652aEugubutZtIy808dFHMhjfHVw8NZYOpwJJ\\\\\\\\\\\\\\\/f9Um9V2GtrwGWySnlLZ82QPnBB7dmrW7I03JqiYxxFwnXAtvZDFGMMgy76UAOM4LDBJbig2TpFsZnyKLaALzJXyd8kjsIXaYpBAwEXFKQ9CsFWpLKxgdupTMTQW\\\\\\\\\\\\\\\/cwXl9vsAmlb3t4\\\\\\\\\\\\\\\/B5hRaO+e7iifOJ19fSyQohxhncYIgQcwnUEGWdKtoSAQP7BGqwYp\\\\\\\\\\\\\\\/WjUYraP5W\\\\\\\\\\\\\\\/ul8vuKrfYlhIfG+nDME9HYhf9oH2x6W9LVz5Kbyq0ihKz7aVuoAtsFlYyq76Ssqe94aKiMCc57JVQtGolWG2H1gVfAiHGCnHAMJJ5h1cjQgzIi1bwTMEgjuygGKJNrKyRwybbg12Ax3RktGdVoD2Gf9k6v1wBT2P2Aaa4E+EY8UxJ+4YzwDitzX88IWsw6j0kC9ceGiCrvYohTVVLryhgUJyH76TJprbybmfDacFM6wRJ5BHVeS03A1LPtuaMDG0Ee0BBoH96NrVSiEO1IbpgoO9\\\\\\\\\\\\\\\/NSXCm5AFiqifyiJskvX1iOrFSD+pp6CD7ljLsLynT7c6qpCBNdHLk3jAP2it9IpRdqlwN5rKBR9m6mm1YZVfJ5wvXLLloiehXWoUeCOCVmLY\\\\\\\\\\\\\\\/syVB2ysVK3xO8GKkNTq2RDb1UGQNznlf6jI9zIqjgkLN1DznY1rusQRdgklqWgmoCh9Wi0LG5GGmrwjP1ILZf0OncGG96xb5V2lRHNn340rrD7itPgepcolknCm2d24TfsTahb+4Zz5Uo8utxfRZPPgJQxND\\\\\\\\\\\\\\\/GihrTm5Qwy1jk8eUnjlLgAX6ZxUMq+tUaBH0htY6lT0120b8eBcXNPRNks5k2z4+Rjr8VZpTnI7s+EWAeaOFAUD4gb829zVeYF9GVxX4HsECmNzJRBe31SOabE8JAVQ\\\\\\\\\\\\\\\/9fJ2XhnXiqhu9Vi+Ud3ITfW6I9yMf5Zy4Ob\\\\\\\\\\\\\\\/9HaYjz63BlspNsX+XTX+PXp3Qz\\\\\\\\\\\\\\\/MNrCp7WBpii0nusFlnGqikGGQMEIRjxJ49dZ0qpReigTRDPgURXQNVYq1OdA4kUUTD1kbkahghu0Zdov9ZYnz1KPYXRk7crk\\\\\\\\\\\\\\\/RMuILTpOlH6pLYaEDD0QJ98oKhl\\\\\\\\\\\\\\\/3tyLXxTztZMSVvAY3ACwBNUuXYJ9FZaLob4edm4WS9oGNxC3jqHgzTIW3wz99oiXm8ZSlqSUQSz8cf1P66zkIq9fbldrxFp6OPG43L4FADma\\\\\\\\\\\\\\\/e\\\\\\\\\\\\\\\/A1HP98eFEODVEsroBYdmNNwDiCx18iHTg6wD0vvreDYClqy4PDAHkSNdNuXUnr9K+bS6H2GN3rNqaAzdVMJ3+3tgEnH7Rdh4492g3bENazLJPnAp6CWJRhU3sJnJC4iEAXSZ1RbcMrO2GjxijujowZSr1evGvM7jFZxNi8QFP1njCWRFvE7WiOJrf3dSbcQrShKZ2Hdx7ep112thB1kO8FMJOf5kLSFDNAhR5N\\\\\\\\\\\\\\\/raZ5lb7bRlRGH1XeO1uRTBhVkewn1xxKUylcw4VGmOz3Xf7pecP2TKuAS1ihNVX\\\\\\\\\\\\\\\/NVS8ik9Fqi2mhTo5UfNC+SRj6BMDZxnyz3Vzb\\\\\\\\\\\\\\\/jUeBJqTayL8kPlB\\\\\\\\\\\\\\\/s7lkdyHxucbGiEQ28ybh4ZohEoNqayZIa1MHKcx5RTqNbYa82kHJ+6n1PTM+8BdPd8kQZ2VjTLPWcTYRVpjd0xl\\\\\\\\\\\\\\\/J38WlQeSK\\\\\\\\\\\\\\\/pqbnr944FOBhEJYOZzI0LP5LKr0fy70pGflUkWwScob+cKyxoSmJdLquklIeXEw7\\\\\\\\\\\\\\\/x4IAekl\\\\\\\\\\\\\\\/M951+TOHRj50xSJ8YiNc2\\\\\\\\\\\\\\\/Xe8CC6njT71C+7LP87+ZqCXB8a+F0L9Ncl1l9TMYujXLVWFaZSyGTOva5Onh+D\\\\\\\\\\\\\\\/DXC3wCz3u0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022qw7iv9+jmemWmbpyJrTgnw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022146ce2644458c32b99722116d160d8c20da440fd1e8b00b162d8dc8b33535d26\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/4\\\/e008818.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/4\\\/e008818.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2024-008818\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2024-008818\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2024-008818\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}