{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221C1lbg9K4p+WfcaB4ktJdcCjDpRuEcgt9CQhs0TdJ7vPAbW8j6bsbKJy9pdsz\\\\\\\\\\\\\\\/nFjXlb+NgNlPd1e79zZIr+ZWaxYqYj4pbyTAWswAuwbT2AEc4KETYWESkO0FhzfRSjzxL1jzhUj8mEKHhIf+X058FJKhwTTP7NMkUu3nMnx5w5OrCGbw1w7sjLUukOgI9Fne138slM9tWE2ZHN03swWpbVnBnqT6XMVvbrhlJBCVLdwpe6y88odPs1nMqJ2NqAS5dEKTD+BAae1SG2xiJyUBrfKEqcMECZb7iwfZI+MLOiSjIWsUo1vrRCK52lKNyycxKoQh2FMzcXROkIxLcQPYuyy8LhMQsPakKUz379feIn0y+leQOzF\\\\\\\\\\\\\\\/4Ct4FtJbMjfgPYM5y+yYuLCOmapIiND1Yxp2VBIyBRPBynbiiqvgSBS1\\\\\\\\\\\\\\\/LwVEf3viNr6hZ\\\\\\\\\\\\\\\/GJT3TI4G98+8HzGc3a5QMtbqOhNhMVnhwvggzKBDE07EiBi4olXaP7T\\\\\\\\\\\\\\\/o2eayprLjaEef2oVVgktcNHWsRvsMGxBPuyVcmjURmzVdqwJLS7\\\\\\\\\\\\\\\/ismRAKKAGkKTCuJLPCsWO\\\\\\\\\\\\\\\/CXCi9qX0SMexBz8kz2kW\\\\\\\\\\\\\\\/UwcN521Uy2PRtjmyry2wcNowte\\\\\\\\\\\\\\\/Ur8WV+3vgDoJX12tI1sEQefpRLy25S0xOZQYv+dyCIAQAOC7t8CqQJvA4xVpwbC2VMMffTrEsixYiDN9NDJksquwl3aFVyv9euDDA9nDCPwV3zhfXnuX4SAxzXtdwegrLSx6ARRFqH4GURLnWABoX+tzvRD5kGVVw1kdrK09vINv4jOsmZ\\\\\\\\\\\\\\\/WTUxDk475m20daE1eQPZTo14fhsffw+NHum3SDIIC6hIwvY8YlCzTaUJ2jTVncUBt5Si5\\\\\\\\\\\\\\\/j1xuNDmCEhGDjbec6DlVwi4C1TJU9lZ272NP0j72930Joqp406qbu\\\\\\\\\\\\\\\/vNrvdEkPIHKtM88xUffVLlLW6F8E7kNy2XU+YtF64QDCwNA8qFyojjYyYJOI4RnfE5q9vBI75gYThoexjLonlAciB86Mh6eM5REdo+ZtrJt9Fsqd+LrNEL\\\\\\\\\\\\\\\/scWzz\\\\\\\\\\\\\\\/SyBy7xDF7BokEHhkB4o5Ui2fZYv\\\\\\\\\\\\\\\/xM3HQdZ81JR80xJAQFKYWZv02M7ZoJiFGqKU339pg3XQib9VnOifNEXWjbBNDTUbaeenycVlBu9TJ0fxQTsyq9\\\\\\\\\\\\\\\/Zt8CNaumimnmCLQkMlp5nZPvci5dH1NPCwgBvQbp4R8krVp6qfJv0gOCOpQnxnk6TBmXtm\\\\\\\\\\\\\\\/x49cxqbmyO94O3lGpVf4SqIU0cXisCQitIUvfIxZVw\\\\\\\\\\\\\\\/jQjAYLSeAP6oFWSGwCphuwRkFU46taXel0fhxOXV6f7NTKBlbTUdgg27OA9yaSc0ueG2AbbfecZ3JvSEMoI2RRxt126FLS\\\\\\\\\\\\\\\/jWPyUeMdyVLBHCrq+0JguqCcCC15AdN2GlJvzjfEYxRfQ1jChupddq9\\\\\\\\\\\\\\\/Q49Lp8C1fZr91G23odQ2z2BY5H5CCz2Q\\\\\\\\\\\\\\\/6Fkj1YKXeRXIg0gmJDpDRDVDBbzapEOGZUMTqoZlQYirTD2u4xZ7DXiii\\\\\\\\\\\\\\\/KdDeJsftZq2llvmS4i\\\\\\\\\\\\\\\/Km38uw3acrGHTxH+dMVCMgFXVtfQ7oDe0pDDRRmccJDDxAqDuWZWvEkzFk9vQyYB3vBT7EhrbGgOADDZSlxUPwhh\\\\\\\\\\\\\\\/EKSBsURVwAG4YPsFnXokPsf0Kwu5RnG6pZ89EsdDSfrEwF6dLSkK2u6AFoHisfmdKNPydIbhFqt67tvWsqOj8zWjPYMbVmEpQuN5cnBlUXFBrBjQMvGLgEkgx+vL8IemvkJ604HI2AVMqQfpIL9sQSE3qthg2RbF1jiCpfiLm+TlBeCb8+mm+RH96FyXHEEMSPyUuW0x8t9D8ee\\\\\\\\\\\\\\\/7p5Ytj89cYadmsEK4sECgJRITHWKMXY6rYkTjHm5Yvw1Msdqi5U9g0wNQtJunQ50jzwel4SViLefX3T2d+AxL6E9yTRgKHIn9\\\\\\\\\\\\\\\/SgRuvKvLvzFTRh8ls1Gl\\\\\\\\\\\\\\\/2ZRaud974j+AspFKbvYhUO2OnqMqln+TItNbuBsPXkxFlZMZWim\\\\\\\\\\\\\\\/GjsrJkhUgnAopmThGnEFEJbvZauL2wQP\\\\\\\\\\\\\\\/k2pNRJEKlDQuKMhbjihYmiy4fXhBV0ZhqG59wifn8xYER5G8IguBoNgZ34RcSqjVT6Q4dW\\\\\\\\\\\\\\\/9DpiqkTUsL8tIiYoxh+aB63XezljLYWOCa1wOA18uy+BkyZF7graxRk6On4mA2KwXUM8EH28IqwaduTBpJWv\\\\\\\\\\\\\\\/AK9zTc2O8Tq8Aya5HIkOxmQBIJTH+VvC780ZF1svIBsIdLAPQjAZihihThlv8LyigWGP4xn2ID527wkQ8yg8zBN21HdjRDbCb5OZ\\\\\\\\\\\\\\\/IbE7lvr09UJXSwTEjdk7gPAiTPQZG+uxOMl48ryOk4MIYSB2eiDjKUwsMT+DnnqA2ZzHWYXLCxPYekye\\\\\\\\\\\\\\\/14I6NJ0QkuPiHIDQu4hC9SB5af27aYv5+x8S49Zm97Co7oO6nfjh5lrzMIQlzDKAD+SrSTW5oPLRzSULoWjPwS\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Rko++hQ+ZDc+os3o2U0oAAA9VsUARryS5lQQdBbS\\\\\\\\\\\\\\\/41EuTeKdXiWaS3c3NK0ZeIfzom9LXXPVfsAdc9t9oePVScWDbsouLyW4fP0PBN0TT\\\\\\\\\\\\\\\/SQvgZbh0qw8zs94cK1jUj86qqT+k=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022uJFncw1pQoj\\\\\\\\\\\\\\\/9kxHrbghVQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022cc398e2b8e47b1878cfb6610ec3b8720d3bd3b7bb1438e4f2198697b059c2960\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/60.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/60.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0166-5\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0166-5\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0166-5\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}