{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00220j1uucHACa3CT\\\\\\\\\\\\\\\/lEMQru1BhcRZ0zh9Tk1E\\\\\\\\\\\\\\\/jkWRViDpcHDvmilxHj5C\\\\\\\\\\\\\\\/Xd3jYXhRXoC54lEJCs3taHWDtWekogEEn\\\\\\\\\\\\\\\/7K+6eq+DH5qtezXxfBC2xzmo6tmR9Ea2oJIWa+v17MUJTiAHtK5PO6KUXh3h8X5he17K4sdU6F37ohKPdfxt6l3\\\\\\\\\\\\\\\/C1MAigC+0RlM72R6HbcflZF1I3Yi7yJ1PPWhfQiR9\\\\\\\\\\\\\\\/5Fi\\\\\\\\\\\\\\\/7Rtk\\\\\\\\\\\\\\\/CVYZbqMf4YTM\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/NcZT8p93i3MckvO2S1BQkMbXK8o2ZpQ58Aga9o0jC5CwUZEe5HNZ8Z4F6vgrpQ0j3YRc7WqjFBBo9rBzOhHbuLU9M16cB+IcHqqhoiCk\\\\\\\\\\\\\\\/VCH6vK0wjklYB2tlszVH4gq2fMs5U\\\\\\\\\\\\\\\/WfAkUM9GZaASM\\\\\\\\\\\\\\\/BZs6OhM\\\\\\\\\\\\\\\/tRE9US\\\\\\\\\\\\\\\/Vrt7LPRSPl0UZxCTH9\\\\\\\\\\\\\\\/kR7O0O8wkAtp641APe+ZYhypqF1RMYhbXeFz0RyYGT+mj1+Gm\\\\\\\\\\\\\\\/uwnTXUg\\\\\\\\\\\\\\\/kxotCHjIce3DqQC5\\\\\\\\\\\\\\\/KkNIWmU7EUSAcdjmN+RaFutSvgQzy3wOLwz2\\\\\\\\\\\\\\\/RX0gwv5pXZWTCZ9Va1odDGtxPyyQJJ\\\\\\\\\\\\\\\/ax5cN\\\\\\\\\\\\\\\/yW+4nZ6nrepg5ZbUz5yk9ljHsC\\\\\\\\\\\\\\\/5cb3VgMtDpekaa48AskbOKFeF+5QClYxkjUeqDnu2TiLECHdayDVP9ortqiXYcABUaVMYA9QIp6H+8y6vgMBo966bd1QFu88AfJwkofJl9Hx3gb\\\\\\\\\\\\\\\/jB97u2UhatS\\\\\\\\\\\\\\\/lk\\\\\\\\\\\\\\\/DG9VtjXOflxHFEDBMH39fMY4u6vh0FFBVh1fhY2u8kyL15MqriDvfe+2usZ3b7lFt39U\\\\\\\\\\\\\\\/rS6T8jBCa0aSnRn8cgYVblPJCRzTGwPsAxj35n\\\\\\\\\\\\\\\/HyRWh4FF0QG2Vr9eKMzqJsPt33fC+mmTR49Y1S4pkZSPrDUsnuoMXO0l9gGUHf+IGWdYQmclJHGaIlPVh8d1IvaOYhJ9xleNZsz67HUqaReTGWwOX1\\\\\\\\\\\\\\\/y1aeiU85Tiu7UiH4NAa4JaTq0Hktha+\\\\\\\\\\\\\\\/wdAqY+riZSKqE18oiBR4gmUzUFQg4\\\\\\\\\\\\\\\/agfm\\\\\\\\\\\\\\\/U4b4IivbXLlCfmdNQ5A5zn1ERXe+aqCOfn+4PRmzvy0wZovqijv+Eawo07Nvq\\\\\\\\\\\\\\\/pXSCG3hqBQVtWH8pHi6zIhqF32y2hRWybqUohXLUokcMd3VH0XGbJkLRwWnljfAcKhfyDtzbV9BK4RrooTX4auBCkN7uxMI+3AfcUROHE2tybstVnP3D5dWnaWjdjrAWy030sEUms9EyZdYFoMVJrGz3FbupGreRn5VkgvXWJmCMZIHtgr1a2OSYlQsD3VsIwO06OyuTMRJilF3YkB8bvZBGFH+SDVyXSDQ2Se0Wp2\\\\\\\\\\\\\\\/Yo3nCWoCoi0tYqMdpVBxouL71SGuh8hC3GN8f3zl+JI2f2TDUkabCOwuxDtLVLyR4Lh9scbDSRx9IOXyT1BKjtPc3ZdsiDmUFTn69x7t7\\\\\\\\\\\\\\\/aOQrHVS5n+bT\\\\\\\\\\\\\\\/3dwDMyCte\\\\\\\\\\\\\\\/A3RxxynIOnghbt2UE\\\\\\\\\\\\\\\/Kfci6OmKVwVd06dLdLvDZ5q12JVeEnFgVUZgYRFgMlnFQ+j2Hlx9+9O2wo7iJz0GjqbtGiWQM5Y0BvNZEe6RZ\\\\\\\\\\\\\\\/asu\\\\\\\\\\\\\\\/YkcfaEe6i9EbiVmzrBX5QI\\\\\\\\\\\\\\\/zG4P\\\\\\\\\\\\\\\/GUvYoTxBcWJ2wFSO7w0kz9GCoF4F7qX78lScbjW99a8uZoXp4ErAcDyFPbUgfpx0hjvt5iR5+oEj8FizM8Y3MxKoJ+gStvATnq44xy6su4w9Boa8XEgtne5ChKoZzyZdmEP6aADM9mEjPITHdTmWD4JyMzmKiTVRHpY\\\\\\\\\\\\\\\/Tz4EL8gmO9yW+L46bjG\\\\\\\\\\\\\\\/K2xJG8uHJRzgAJEVgc6aaWlHlDkTIXihgywrBj3vRwuMyfhGCzqXNIZ9FC8VqP2zL73pIdCzvkwAc+wrIQlH18HeBd1iZxPRTvBoPCxVKd1kjoerHYVpkgLz\\\\\\\\\\\\\\\/OFHnuu00ZLgzEyS4Q0o6AxviOvVuQ43EvD7\\\\\\\\\\\\\\\/XoaTsMmrMyYCpa39hPstHNnkqzJ0COnQMoJjP1\\\\\\\\\\\\\\\/nmS+C9aXuNhi2LMBCcwyxm+CBdkg6bI\\\\\\\\\\\\\\\/rmR0JbmGcx0Sso6QLcrSpD9VaxXgvfD45OVL3zL3BBF9X+V6PvBELsuqs1o4jCdyvp0B6NZHtTAseCC0M9nk7k369Cmosl2RBvDpQ0DYIYH\\\\\\\\\\\\\\\/WljQkCece6VOk7LYJEB0F92QTadJy5NakKcElM+PCFtQcD\\\\\\\\\\\\\\\/zPZDQudOHcu0CMk1OqlCVxD1rNlBCplYO2bE6zHSeViw9FUVRpaaCAvikR7eGNhh2JaR0V8geE16JMpKY2b1YEJaZM7s77UGvm8uJChoqd1+TTWBtOOHb3mvwdkbiJ4VA4aJH4FNcOB7NfBY+VQvaFXOdaOmKHMWriBdjmXKDTnuMQvKYSLiZa5Zvmi480Evcm6eCZwU0h7DkiNwnIw4eZPb18J0kPP178ZRcY+UEoNSU2pxNTp9WHjQO6RRAzGuO5WRP80qxXLOKPrlc9ta55DJXV8U2Wdz3q6dr4M6JL9KBpKRvH2IloCjQ7ViTkX4kX5+f9Ar6M5LzwDNrZIqQuEpIE1sJiVFs9QRnWpmD2YHdKX6hiXAL91KDXnPlHaIsDCn+RdF\\\\\\\\\\\\\\\/3D32PKbGr8Eye2r6bq+qlwzJGu+JujH7LYT0VDWzqvBkBRWbpFHascP8O1kz90=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022u5rZX2PpklX+PQ0dthjx6g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f12b34322a8881165444eb6c1aea3e1fdd6fee7d57a0004b6512b8e2c3ad37d0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/60.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/60.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0166-5\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0166-5\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0166-5\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}