{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00225qR+n3u3UAirLAhXZ8mWT3+nW\\\\\\\\\\\\\\\/mgn5U6qu2\\\\\\\\\\\\\\\/A8jTMxJc0jvHG3GZ8iHqX5imrBg63hoTzbDKKkEZL70qGAzMHB3L4+f7Odw+C+pNcHBYPklYBErTvoS12kWtSi+0WRWs\\\\\\\\\\\\\\\/JXPlHtCzqGfLE8CURZOyJT5isni7RUm5uFQ5A5usSmX5Ezgzf289lAAFyxFL96b\\\\\\\\\\\\\\\/fc7Y8ks2xUtdRQscqHUBKCvgKfCuKHdWifm+nY5dUMPRwiu3pZU0SokErTg\\\\\\\\\\\\\\\/b8EWHzOG4q0UB0SHIN5J2GcBg2K9T6POKI6ve8zulhLcHN+vxel00ri+NmKZ7ukH\\\\\\\\\\\\\\\/3tBmZCHhlydv8veu3ZzbzorvnHaJJcKRXyQaHG+7FpMVYdmVqEHGabc+EneZ7qYdMIJSuF7nt7jpMBatHP72AqjGf5gK9VBWLQ11W+yAja3VDZfaowHdC\\\\\\\\\\\\\\\/TJ0IsAoz0inXOb6SPRPog5zJzRicLGiVsrtZqNVmTkkNkjbh8dJNLz1ojKq4cb3mF62B+ypJpLTl35ucqeM73yPaVA4A1eoaGmh3MNXTv5h4V393IWw1Y4N1zXWDw6KbuY4M6vDaUo5cfgr8jOvKTNWBb1u\\\\\\\\\\\\\\\/agvYNjICo71LFEXNtWGs3lpDeTbMzm5U6jiU0IZ0R+psgljsYof70srMkPiPuUBXNkeTM5M4GxNg5fPMfoodEUMYKG+uPNDiQtUQ6YeSJm9yKv9UGgBFi15dxz\\\\\\\\\\\\\\\/ofNWUFcTzgOFJXGdaLBSVTWoGx6Jx7GcSmT2vMMiTu5Saa8Jlwml8rmFa7QEsf0ktXQ4HV4xafO\\\\\\\\\\\\\\\/X2tc3fCPuKAwPfRvFnBLJz4BNhZBTNYsIkHlEzEiq2MsoxJgEFBU6T4DFiSPzexdlyJ4omwuXjMZleeRrKwGMizv9znjj3yPLDEjL2UbC9LhkcfOuXhd\\\\\\\\\\\\\\\/AqurDizral7Mvvplf6zwLcAN7bl\\\\\\\\\\\\\\\/gCDVDRL85WimTRvJmbv9tIN1UlYblJLRPvnTpylGOSzsbUYPStmhdsTgHthCQq6Udu5lu\\\\\\\\\\\\\\\/JS7CZ5Bf1bMeJ5GTDMnfCZY7AXCKXrF4FjVpI6CJKlCm0TaCXKjracSh3dDuCiznjt1AP\\\\\\\\\\\\\\\/WJfOKWyJ\\\\\\\\\\\\\\\/KsR9hNQQAxQhC2301OcVgNPxvenfwHdv3OYLCEwU7xyNwguh1Y0BMSCWm27NiL9AR0PJYBXp3fmElTMdH1lHEzKy3E+kTzR5UUWJbYkKPcgTfGdoqS1wcC7Ujn2KjssvUuZEYv4\\\\\\\\\\\\\\\/NRnuc3cBp2GNSCOL2pMZe4ujep9lhVNLbo1gX+4xzgOwJNFMsEs0q027BxQ98YC9JDaqFNC1PkLa4JSbqLI2uTMenKNio6XOzEI7xMApQAwtPSGclXAndqb80ekTterUCkstujrATrAqvPXbXiKeevJjPUmUDsufLs+iv3qWOgZnauJG6a\\\\\\\\\\\\\\\/x4iT0bkYRD9x0aGolhPPy9Xq3DkWhitgFaIvcanrKMjT8e1SkGhuaFBEzPpy+ZKxpj5Ml8VhN8KAyr5mykdc6amDPhwMvM4DBCvvCkbc6LWFG4nzrTIbTcnn3pgQLepen4j0QmGstGVsfJRSnmMMfwJ\\\\\\\\\\\\\\\/Ij\\\\\\\\\\\\\\\/prgx8ZVSdv0QsI3m\\\\\\\\\\\\\\\/0NIk4SXj9ho8elzlKhCYRPf1TqQg4cVMdskPeq1xl7vfXg5u5q0aJZJSaw\\\\\\\\\\\\\\\/uYFC2R6to1xvhcG\\\\\\\\\\\\\\\/gpgq3wMBvfV5NHFi2sHJ1zCzgg40DlmI107EOFi+IwLtnMqUkem+b87KdlivIpsJWBS0RUeQNAqzaeK\\\\\\\\\\\\\\\/qpRg83b5m6QBT5TMlV86mREiuC\\\\\\\\\\\\\\\/LIerOCYDmB0Pdcgc1BQEOqZe8ipz9T8+yH6u8mXYsLrWcC58flKNH2z56xYrnyiMzgIAtCDUL++fa0XV1cmEMQPZMq15KJantgRg3NDhEphAKw1JhM5wX0hLs3FTkASFKltiXbr8Fqnby+ZW40NEwT0SBKV7pGnYsFGBfQQy+bvpasz1r7uYYA5MWdqdpslPvZYGGQhJtmBIi9Otp24A5mYGhNDRFlTf5OCNvn0MsvDtQYOrcKyOhX61QLOEBSePvFwjCmsBtItWbNXRY5dbeKWcGgYENEI7qJh3y07b7yHgYu52rBrUSJjlQFjpikgOIRwGpQnywGmOei+kN4nVDk2PsjmmpdTquFI867Ruk1YSaG0MCOzPfUw6n8JaCYxJF9vC2RMBFd5qoNikRfBz\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/ab+wmDeCvVwO5DiRsI07+OU6k4xz4BreZ1Qbrz9XdhBGMsXG0DS\\\\\\\\\\\\\\\/QURSOHa7oq9IjR0OFT1jLEZctlcdPT7sUX5pJuYd5sdsUcmd34DTpdKUM\\\\\\\\\\\\\\\/RkRQCWVmtTyJruMo1OC0d\\\\\\\\\\\\\\\/L6qQTo2k+MmRjqCzRGaLmIAqT5\\\\\\\\\\\\\\\/Ybn2y5zynP+2uxFNyCsKod0uw\\\\\\\\\\\\\\\/NQhYOtunAZSzBitbnFmWUUlxQr6DssK+PhXrhVYluY30alSWeQ3tOaqog7nPJ3+7NQanORY6FIm5uUeqq3SOSqhBOxCgSYLe5cUKs+NRV0KQiK3VkgIXGMXksYBJKtK0ybaaqVHvoobV7rzpqnoi4isGlXK7zkpdtgmv\\\\\\\\\\\\\\\/M6na5mbGWNdIk3cyArFZygoCzCmA7D\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/k1ooaauD7MX4eG9ZdkAG1MZuIfGiyTpOnlNz5ouejJ4Q7PO9vO3QwgezAHCr0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022pYlikIGW4sM61ZaFS\\\\\\\\\\\\\\\/MQKg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022862bd7459dc06a05053792928e1f0ef55d2f1e514be1d2bb50b8fef157afb8fc\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/4\\\/e008261.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/4\\\/e008261.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008261\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008261\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008261\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first\u0022\u003E\n\u003Cli class=\u0022last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}