{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022J5OJo6NCQpj\\\\\\\\\\\\\\\/HUk9LIXy1vz5zBKDFRYL9KHNfWxayRaA4ayFS+t796gKHth3mLZmWPYRznkNw87yY0UfJXA\\\\\\\\\\\\\\\/3SlREDLIij55S04wTq+bs0na9F6PS9vkxYGBzg04z0TjRiifyEDpc6n0Aa9GuJDWzoQgs59w1h+CJY5z5AUz6GU97HoEoaMW8+lL46ZjSxK+WEjVcWTLMg12y6727XH8q5hHFrpkJ63T\\\\\\\\\\\\\\\/67NM4FEgWhrGnDFIV61dnfuThvFf18vpJZkMPNkl3Wq\\\\\\\\\\\\\\\/RG8nZmBfhBjsy4b8sFIlQnAD\\\\\\\\\\\\\\\/ABz7FLfHR39o+26kmkKHGXaOqU2RJZiE6ng5vyZ8tGy7IsiIQXwb50maqUk5SXEGzEf7t0tmUfNeZQUIkOQdwxNE6\\\\\\\\\\\\\\\/ZcC5Qhuj1EfpJwaNWTQP4iXXCUZLLJRl+BGBh\\\\\\\\\\\\\\\/Bqac2u\\\\\\\\\\\\\\\/oojSJw7Jle1F7ItO5aZAXesoEye9Q\\\\\\\\\\\\\\\/X2KLqvGYfapwqcodFV3z+I1dKzaN8+T6rFIaBP1dG4gkSHXiCPEVL6Fw8vFlIyzUj8vtOeREkLZ1UoAATfF8MEt2dlc4VhVurxQ29cQv87vnPUWdP8hD6A7sTKdofQj0Z339TT3K+ImPxyh+ZeBBZ9XqYvV3N1f5E+1fggP4lzz5V7yh8gJTlaIWYuQR0KfFgY7W76M+ojDdb8sdzHD7KUgUuvny3USL++ENrFdcVtSxexDvN9X2rVAX4Kyd6ef8PLEmOUGKp4c3qHojjUjNRUrUslcJP+mGSodhsCUzKzP2KOzPxKgrqckW2OGai3MWhMju9NPaNwYJp+VH9aY2HD9wC43iWTzzhsPVXN271XgGmklYvGKBbo9IHnn3C0u4y7\\\\\\\\\\\\\\\/aFlJgJV6JjOFfMo0D5O1RlTYryPdbYzlvPDqsoweN6CcbhJ7ispTKOtftdt4wMga27jvFwQ535J6Fp4ZmVd4F2rRxFEfKMO1CE41byfd87Ywp7GvjA3EgUsXGKiy\\\\\\\\\\\\\\\/KLWgzykjo5L+H2QyFg4Uy0tk8IW5HxCvYkndOyEiVV3UgHfs310uOfa7Kjhn5tDHDaOFXmxx26eNz96tN+0p9M11nxvdEhEtvWSWXma3H4ajFuYG6NB63ULPkY7bLQldTYK1PMwUg1PiU778wFI9y0gmijK1e5kEEhxRcoVcZEmdN0FM6tewCUYKJPUg+IKhDS\\\\\\\\\\\\\\\/azdpTWFIEhlFEvIv9Lvi0uQ6BJyB3oQtB\\\\\\\\\\\\\\\/gN\\\\\\\\\\\\\\\/LMU3k9XYQ5mRMuvmuHrTkoLThgsHQeDz1AefqN+VAP\\\\\\\\\\\\\\\/n2XIZhw82Ogy0Y1Hu6u4bi0FxGmT+6tosticb\\\\\\\\\\\\\\\/g4uRmaTiI9kisfW9ue+K\\\\\\\\\\\\\\\/blpImipuzxwQBsqwtBh8o+fuZo5XvG0kOZOA0M5\\\\\\\\\\\\\\\/Oy4H7bmjHInqx3Z2FMq82x+OUWq6B5clzOUNS93iEWH0cZvc7trrG+qbdO6Nt10\\\\\\\\\\\\\\\/XLPCgV+4VrNTTnGwyOCn9\\\\\\\\\\\\\\\/Soq5c0O\\\\\\\\\\\\\\\/JRKeVQmxlePLkygUlpx2nWGMgqAJPD3JqJXubRoJ6GzMXyZJ297n\\\\\\\\\\\\\\\/86EerO2cOSPH\\\\\\\\\\\\\\\/z2bg\\\\\\\\\\\\\\\/Zl9XrgHpgNMloF0bBpEJfEhhQGWnN9Kw++ENOjCF6Z\\\\\\\\\\\\\\\/Hu7zXl0HUlhhw6THjs53NJm3y1Uw2iiRP5uC\\\\\\\\\\\\\\\/CgTdmbV9zdDgTp\\\\\\\\\\\\\\\/0RsYs3rzPqqx27BSmre69cJhLbIZT6f+2TzXR5ue163WPOYNDhyEglxSZVcwHb9KUJqW5BhAd24prUtSZyVyG8Uw6qcWSWEjb+M7b+3laUEeMnS04HIDbTq098yHLuGwfQK1RFoCCAc5TfL0MhL4x8E+zOl2xF5bgUtMhzobHnwbeXevbPKDRA2EeWgg11\\\\\\\\\\\\\\\/K2asMgiztmL8M2\\\\\\\\\\\\\\\/M3ovNmxuvRYZYVhujJ3rW2y2APfKy3jLS26KXjAUCqOTNTBiaI0OvOmHYXKojC+WIIVxSXBpY1u5CZUwhdQ43adBECZTDixZKGMuuKPcYY7gCeyVLIgcngRqH4\\\\\\\\\\\\\\\/CvPxewKKnQrOpxfg6k+2K2wImyZrBAtTfaxeW0isx6bpiH1ouBQfV+jKlS\\\\\\\\\\\\\\\/JlCA3wKi0kDgPL29Xlrz+JgXROP+2BenVxI34QQHu51RLXGwr0DDYbHtfJ9tujEFw04ak5NLZhY4+8G0CStdr550q\\\\\\\\\\\\\\\/edKsyRi2NcZnO+GWJMYRXHr\\\\\\\\\\\\\\\/bu6zTxp4qFQHnUqOlkuPufg\\\\\\\\\\\\\\\/ENLEvYPH52r4QXYCruU1cyjThBGZSLRT\\\\\\\\\\\\\\\/qA9xUrrXJFtsTxrch+n4Eo2sBIVDSR0Zsf\\\\\\\\\\\\\\\/bIeCknupvfmOxrDzuFRQ\\\\\\\\\\\\\\\/LizfDNtfefeiCr\\\\\\\\\\\\\\\/Z1OtA8llD96fvbLG7qRGidaizEs4oWU+ThVSXpEQbr0z4Ctvb7K3J6ahuwu68ygTJPI+MchL4OiYeyim+ZmglyA4Rm1MxCOQB7badGqB9PZSUM71eRakwC2L+uqFWjXF0Y4axJXczsxh34d8Uy2V4CzIapFkA+m5IQmQL9cLCqG\\\\\\\\\\\\\\\/136GyzqynGBRNQZjjz+hzFYMGWG+k5L5b6m\\\\\\\\\\\\\\\/tuuBqFcgqOJediTPYD1yi6vUx98maKuQpeEkJbPtNsy\\\\\\\\\\\\\\\/7KNILPPm5giMLmYFepm5KQmJv4rjPOsX5VR6gxrR3uzZgRvrNc6A\\\\\\\\\\\\\\\/pdDizIXWDQgPaD6fB6HwSUI1Ow108vS5kVVP1cg3xopxGiGRsHxuuPFacbFNR8E=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022VMzxM8wyairDT7cvIkm+Bw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221507d949492d3da07a68f710543b3d4988a3fb8d7b71dc4eb0093b1574c91fc2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/34.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/34.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0137-x\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0137-x\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0137-x\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}