{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Yp5M0WOBMxz7XEbA\\\\\\\\\\\\\\\/nay+FkcFtOnK7JprExNhLzxDxJMybfZFQBfyEhJN5VG5djNjjE81I5PqmAnibYDSunq2rymf60E5iL5+ekjK3IO4QstoDYLC+ZodNofk3mVPgGmwaMXhoP6EVPi1o54D2jxPaOlboPdkObBYvHzJ2i1H30vqC8wsfAL3g5zW5c3ymuJqgv2QmEqjlDJBxWB\\\\\\\\\\\\\\\/d1p4D9iu5c04+56aGQo6XkR1FfAKsjC5tGuLX+IBiF6Fcn7Er35+yg1jckyi5gkggMzGHt5GfXSpewPkMbUP8iUugfIRSF5GZn\\\\\\\\\\\\\\\/EjCCMZJmLzWDGATE7\\\\\\\\\\\\\\\/bIciwAzjN3w3dB+dWItQflilkO0fDcuKW5DD3mzTrVng0\\\\\\\\\\\\\\\/KxQXYuS\\\\\\\\\\\\\\\/3ZUYJE09+F07MqowPsDWQoNAZwNlorqWjgI5uEYa8Xr8ijBFwdvAxfec2fdm3CwcQ\\\\\\\\\\\\\\\/Q7S+dFWq+y+DFUOW8zI0pDgYxTvUcAwtNWHsgxPV7mfZ4Jc+C+AwraoD\\\\\\\\\\\\\\\/mrf5bEvgDTekvxWLkx2Kq5Gl\\\\\\\\\\\\\\\/3xa74doNYRpKmKB+Si4nXST7\\\\\\\\\\\\\\\/HWnA+2DbCy3\\\\\\\\\\\\\\\/22lGCWfY8+XN1fUkjtLoo8PaTDKN2oUizpnqpmeZYYIPRjovwDy2zSdkq2gjCaE5KZf8KTPmNbNxRO6UXOfmk5yg+iXc3JgF1o9PcDj4cgMPbpMLmOfSP95RqEsG\\\\\\\\\\\\\\\/44t3rxFFwq5qVxsjnk8uEX5tlPlpE0vE8xsB8EjXApWPxxPvikOLjs+kjW1RSpl3O+Egd0a1Nje67+kOm3l8IP6KvnfkCgcVoKvd\\\\\\\\\\\\\\\/UQXPL8vwyY7ksXPfMrW8H7eU4q+wXkira6sBO8o7CJir1g1ZkU\\\\\\\\\\\\\\\/K+CoyI7Q3DFm76vRD9e2YyJ9kR4YJIl7UmVJUL+hYeHtK8Pl9nTd39fR8tAVrQAV8ypJCmNWKpKqv8gB4hNWNGV2OEbY\\\\\\\\\\\\\\\/N6MQLAXr46HvPKndOerbId3veJg0HAXLG8njQxeSIsJ0fXSwFOWOHCJULp4RIpzJc+uE2yYAgskjwkrz15Ws0057Nq5doFRopeauPkx+YAeJIygSx+gjTDrjX8zbyNhcPR\\\\\\\\\\\\\\\/GCIUdKlmpIQqiQin\\\\\\\\\\\\\\\/RrBzoBsLd07Z+xHDXqjR0jj8lJZi04ewFvw7EEbLUkh0mpE46yKBYgeb73GTzFqIwlfmK95kYFgGDRnAAUTDnT1dccf\\\\\\\\\\\\\\\/8wQgQcCxFjIs+1BymJ4f0O\\\\\\\\\\\\\\\/msqHALQDQC4tn69EfvGqdX4WL5BBj1GK+dhENygJinYs8hK6UjAa6ad5Kh4miUjCbKz6xTWssLDfiAX0ZUq7CEl1xGOmh3bHa885HzuCnpVlypGAwGF7k6VwuwHPbAYeChL7C9vwOY34VMbjgJBV2yme6vhoL6NNnYQjgd8C\\\\\\\\\\\\\\\/ASf2S2ooLCFJXsdKkjj+JVnOPe+mJYVWfeeZbY+wUp1535XY6BQK0SsL8Kpk11jLq93zhU9KT0YHmp3m6YnrHrHfcDrJaxi7zUkxATCN6sb7+WL\\\\\\\\\\\\\\\/kAp1teqPD0oBiDzW2Ca\\\\\\\\\\\\\\\/CQAPJGOPMzNdxSYVt5t+fvkaLe4sjfCQ35REd0kLUWRI3ZsbJiMYSXaDP8\\\\\\\\\\\\\\\/SwB0iVmfv5xWwoH3kw36PQQHrJfiO6IcqNK\\\\\\\\\\\\\\\/g8uQdVprqIIpRUq7qygeJtP8m59vrtswKm2eXL0zEEUvDoK2L2O8+maaEii45fTARGIwSMEvlmpUlGHioco5KbYKABbj3Lm5QGZceCqvlz6ncOdVwbNqiQdrck0GFi2lSzzmEcFJjVjVqEmy6EMOIF9ALqKppV3YFT8WblF0CwD104DpZawO6Xs27AaYDlHLc8ihirEBND6ZVrKIgWjCd+FlSOJVhxC8GC4JjYqnDr0wYSlCmPeC+Wg+NE8dUjNJ8XMvrIR3+ZTJs9UrsOFvphRBtVNWTbfbVHUTfeAmkCpbNYNsx6oOnHN4tLvQL5NcieQxY8NkAjEGvi8LXD2jZ5Nz9PPmnu8dKNLiWjqmOjDnmXOfmZgH+r80cU1tAcs+H3VidHt3dSqscNE6xUG6PuoFkL7zZq3r0x0fBHpsa4u1RrdBep6QGpE\\\\\\\\\\\\\\\/Gib+nV2JyobXieMrOXyeGI9\\\\\\\\\\\\\\\/63sfq+h7h1TuQNPq3IsHrx1bUqe1oSwzUHB8g\\\\\\\\\\\\\\\/7mzwenmS4OofvCgI0kqbabFd5dlipZIphugN1QCTbNDUGcJtrUbMfcQtIrErM8abUi+bN3XQjiYibjfPbupk4e7G6Vmnf0vJ3MWRYmM1XAWFL4ksEh05h3Rw+GZGv3CvJAD6PlBGUbmYM4wUJSMk\\\\\\\\\\\\\\\/m53yyWbEBCnLyD03ADFcm8UlFBcVc9ACIMaDRUMOi\\\\\\\\\\\\\\\/EsBVekAhgWEQ5pvBgmvWb6vk+6x3QW6dS+he2w7D1XbkAs98fRCuJ1VWcwUdCQXUd5G8+dF1AVBCh0e8arnhoe3alieIib1Hbp2w+brpXtMYNXv8Yoo53asz8VyasSXUU35ZuXMk6Q95bF2H5JCAxl33oY32qGuFBwb7pFSPFSC0Tyclm4+tYmuzFzVzmW+Qk+JaM4HgjLW\\\\\\\\\\\\\\\/ALBAAF\\\\\\\\\\\\\\\/TNYKqcg3KTQb4o2X97+r477LCUgNHE1dRYcLgpjkklRz+1N0zvJWbjuHL56iPD1+cL189xpL2xuDhKTEKSm5qnCFxvotPIU6lID8WI2qM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022xmu4Pa\\\\\\\\\\\\\\\/hBtAqUsfp2fdbyg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022138e0ad790f6ff12fedd2984705b99193602069a10c40a5eb25a227400e04327\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/64.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/64.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0171-8\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0171-8\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0171-8\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}