{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022P\\\\\\\\\\\\\\\/p0\\\\\\\\\\\\\\\/c59yP98Choo8nZopHgfja8OIjGbu0v1X9lOubnRgkxGHMvpuqNMCaJtzMjLahtSSuMwhqlwjXmzXB1fDQuksWkFHCKe0G7YSh\\\\\\\\\\\\\\\/Iqd+48KYBDma\\\\\\\\\\\\\\\/xJRac3ShLeyj9zdLpEcj\\\\\\\\\\\\\\\/FOweM5IoQxVuKqJzpHnRhfiS4AvT1le\\\\\\\\\\\\\\\/f9q0kw1fajZVOYI4eIUMfUvPJ783nTrVpZH7\\\\\\\\\\\\\\\/qDVtZGMMH7vzGiwWQuHK6gtZvNpUXUK3d0TITrGoKcB38eoKkKlFrW7FwbCJVdYXa9tjFkLe4MVvOBPG348FJ7Ex1YGNSwE8qA54lK2OoHeinVKxthAR7Y0v51C9elPyW3JKm\\\\\\\\\\\\\\\/CkdVqM8Bnt9Wzbn5lsl5T\\\\\\\\\\\\\\\/HH++FUOfbrUMT9BdkjIeWXnYH9dbZYy1kh2gaN7PpFybgxvK5swZGu0Wwn0hoqsJCGLOGlhl467FuT8nMVYRR+JIjOTiOuUGy8PIo9C+na3pn9NHJrAbtersdhX13+lgvSjPpeBLPeF+RX93BgPzID7i3\\\\\\\\\\\\\\\/22xftVBeEJ5ZRqBD6b181oiKmcmcPyWf9aUkQCr6us4FY76U6KdKO5htTb9YVte80UUT11R1AHbSjXq6p4O+HUSvegL9L3d\\\\\\\\\\\\\\\/70lmG2ECWgtqwj4IV78VcRUijpI5Z5kJedtQr9XgcftQx3+dT63WldR9IfCg1B+1Kfl4TmDwtyp+Gc2vBu4ypXUS\\\\\\\\\\\\\\\/IcbpKMRDMFQPuf16drFA72K0IE\\\\\\\\\\\\\\\/wkEFQib2S2h02wivfgRkLF42XCst0QkavHZzDQ1mjs3fzZH+MwWU81+4OPrGZ9D4wK55\\\\\\\\\\\\\\\/dyQC3v3phui8Y26DJu4XbICbH94LQWea7AY4Wrga56KmirUUgtQRaX5gf27lfK+PildN7DHLpnMGuzxR1hgIFk9MW7Dc1kSvap8xBPglt0bRWXWBM9ePKy1hLa93379Sb6ujlaInxcLxnakZq2GP8sUBDt3wcd40EKkHusj1CtWmpe94kjeU1r0bBbt3i0w0RAOEksMXkfk1aP58TPAp5Bqe8axRk2I7dcdSzzyfwTGmOR+Tu1HlrZ\\\\\\\\\\\\\\\/ln1kggYj3aC7yFjZ2y4JDhcgbMRE5\\\\\\\\\\\\\\\/6zlAKEwJ2KNJK25GHFJpAV+0c+kwDaxtVgWxFEubAqzcAYO5C7NWdIweYqif+F8cbpZycSdEBoyZU+Smc9EtLKz8pRHNyXn3ldaSK1LFIMfijo0ecqrVo21dRAA8SMJnRLr9Ye7na2\\\\\\\\\\\\\\\/DBatTgvD2ZzJZcDiOIe9QBEbNh7GI7k0\\\\\\\\\\\\\\\/8guvh2zIJgny+53kPKPKOPeb26Gkx6FFMguQM807ueD\\\\\\\\\\\\\\\/knIw\\\\\\\\\\\\\\\/3P+tKrsRSikPEzAymzGZpFjgwTjSOyONNUV0YyqpNOzjYInLS4vf2JLZd7jgnmMn4sxKOFSFfJ6mj5gVpZO0AL7RXUHykFisHYXg\\\\\\\\\\\\\\\/NDap04XjwspjZRVqBDTXrmlHG1sNs2eXIRRL4Nx2Oz1hLRJewvZbNwKrc7v\\\\\\\\\\\\\\\/ssJ7431KWeQ\\\\\\\\\\\\\\\/kfRPbIh0xbPin1NPFjWV8OSwC\\\\\\\\\\\\\\\/VEaVmEa\\\\\\\\\\\\\\\/5\\\\\\\\\\\\\\\/UAl7NrrZz\\\\\\\\\\\\\\\/E1ijw32xPdIOTbwZH4FHrqjimLwq6jjqoJY8FEnKkAQh0M8ZA9aJhvgcx\\\\\\\\\\\\\\\/NsNrn0yj0Yg8S8jo5N92AscThebusEJCcv7q4Eqoi23EY2yZSD\\\\\\\\\\\\\\\/8splG\\\\\\\\\\\\\\\/UG75QHiKYVoC\\\\\\\\\\\\\\\/2i\\\\\\\\\\\\\\\/KBLlCqLkRlzM7x4Ppkxc0YlBqggxbERHaEDMEFDpLfnZuaPhfhntVEcbkdMpRJ4zOdSHO7RDM+FevgQS2JFcSNk5knLclMOS2CXlb5qsgq6IvKt8hQZ9kQzzkiaM\\\\\\\\\\\\\\\/vgaV8PATEZNSj4LDMG7JCTjTiQO2lZLbG0wtRXq2syscGqulxmiM16AxFAa3yXqC2+DtjEkIuxL56KM3O+zMyaAdUzGJf5fZ4TWgX6RHtCJsWcmLEq836Nx56yDzLuwAWk7v7B+4MvRgaFwtZMeCYZGhNKgzgcxlJj46Etp1RofmZLmzwc8tLxBAyxGWfKDbD1y4SjVoIZsiM93Mm0tFl4txXEZyiKBMvuAB5ulibj20Zzf+2IR4ncdB57JPODLdiRWi2bcNbOhcW1PbQzP4sS3qcaFoXJUGY4skn5YLmCzXvhn1BWISQlXdU+vUc3mZC39hUBgT00zool471+iT+uquR7wG9dYw4DcKaOJ1jLQHRM199rQRyJ7r3TBrOYV38aFUO08vpMYs1WK0QZLuJi41oOowGUwQTaxJIwavm5PQvuyPqv9uNqN2L9bzEAtyA\\\\\\\\\\\\\\\/RDOKr3irSr0G2SDzRfyHADc5JDpSUxn0pHI55CtdurwrNzzBBr\\\\\\\\\\\\\\\/lVZTEjZV4qLo1vPPRs6U1IJIlQdHrEk4L\\\\\\\\\\\\\\\/mm4Mqji4SfGYuZ2+dWSX0knRtoX5tNp6Xcu8cFRAHG9I+TJfO8+Nn99g1B\\\\\\\\\\\\\\\/KeqDMmqdnn\\\\\\\\\\\\\\\/mHi0Ug+atupFWaC28jO0k4t1mocwYYJ8Gb120nxcNzarip+RY2U33x\\\\\\\\\\\\\\\/r90BEj\\\\\\\\\\\\\\\/w2aaOqQBe4WpA+9ij\\\\\\\\\\\\\\\/10vzYeDYSAySpaxLsQKuhYbBtdkZe01hhGKln8Pm7Rt6XvmmUlWUPOIrnEXeeFZYLGorMDGjCDm63fuhvRGiuLhS+eCFl2kZNUHL8BOs4hSpdsBaDcR6z4hpPRLZq1AOq\\\\\\\\\\\\\\\/QNB\\\\\\\\\\\\\\\/hMZ4PDIONMjmdk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022OIHj7sf8oiWPM+PsZKa3+Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022eb12be02ba05eda0704fd23061e86e16ebfc0c25cf40bf5fb7a9b80af8fc9156\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/96.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/96.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0189-y\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0189-y\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0189-y\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}