{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u002214vX4vDVKneaMXIgGNqBeJ0VD2BQSz0Qhz0ff9z5yWzBHM0ip8fwNGYaNM2OH5Wtit6fInKSw8cJfBu93rtBvNzloKaTJkIS+n1zFYCoIoQbOnK\\\\\\\\\\\\\\\/KH8d0LEWvvJPyH8CfmixVROdMOCG5eHeQIx78T3ZU48buxW3\\\\\\\\\\\\\\\/xohF9hOJ0kSWRlX9qwnnjXYJbKf1nxKB9GbkJrPgw2foxXSm9fKvvMrLl6Jq00fRtFOTeBFGDeYjMwWTxFT+U+F8nd2o+USy\\\\\\\\\\\\\\\/BnI7pholytPBizAZdPu5nqJZ6+9YmpagGpf\\\\\\\\\\\\\\\/lgfUNms8ucDjBv\\\\\\\\\\\\\\\/7N6L4XF6j9lSXAT+pRWUS3CltvzW8MW9g+yUTA6EuC726nUSdfyzkxxkc8moZdKsil+PlvWIBdmi1ft+MljOuN3tM0G\\\\\\\\\\\\\\\/ys7MjdGNo9F5ul4aYXjOFI+RKKcgBb+sW8pFP8QArqdVXMtq6L8FFE4rqvGVUM8nhv8iKv2NkqcBolFDv0YpooEzaYMJoveKgGs9hTPtjTvVt7wo1awoLaa8K9P4bLGBAfIlVEazJnn54TRPP6x40vfR\\\\\\\\\\\\\\\/ovV\\\\\\\\\\\\\\\/bQ1vnPEGPVqMvXuuq69ok+XDbVSmUX3D\\\\\\\\\\\\\\\/DQ2OfmHGioX7jN7DZgrAgjUHkwafDC78ps3VskLE8oVd7vzONcZEwYAFSp28er6KAWgrXHORq7DLvxZpP1hOqAfQCWwGiJ5veuFL8cXxcGdsf5DEmUmyLw\\\\\\\\\\\\\\\/cKqzKLUpWJ6pvp8acENrKvN77EhWlVE6W0juybhpDG7lpwB\\\\\\\\\\\\\\\/VW4qdd5hlAuCq\\\\\\\\\\\\\\\/w0IcaKNroadBq+X4GSGSmlb0nFwttHFDFvNsUUZIifOOuLUAprgg6orcMw1eULfD89eFbkkFRk85zY8mFf0+1huooESqc1rsst4JGKwJdnoMbK4lSaC5iB8pYldkxF\\\\\\\\\\\\\\\/AYlK6PoHBdoKTC6VnkwcNqv1djn2psJFp9dCvtv69KoGesN1QcPLw4JUUO6iAsIVR2eYJpuFXkGjQyqrXLFo7V29DkaQoItS+8HnHpy3+DeR9bWbgHBsxhlO8j6xIXYYBaz9wtQZrUWu\\\\\\\\\\\\\\\/E8pCyAiBzspEx6EqvmNyKxs21B0fkUnaF\\\\\\\\\\\\\\\/jD60VOLNLbPAW1GUqmWSWzFYd1w33R2MGsh2VjqCnM4nBjAUQjryNfO\\\\\\\\\\\\\\\/O+YhapqiDFjotiGWHpQDrDD38W2yuxjSlz8ncKQuJv9OYWPIItDXIx7BcUD46cSvFA0bV7zVTDstOVujPPlUZHC+9IR\\\\\\\\\\\\\\\/zo9IoljYYjorgOCW+xTcdeURCE3nu4c7qjTIZ7XaG0Gz9IWXjP1Mkrm4f544VNbPEmIUtHvtTyUJrui4\\\\\\\\\\\\\\\/QU\\\\\\\\\\\\\\\/1QEm0QEVrpXaFWgZPPVx1FGUBNNFYVfNlyS+U5l1vtj6WrtqMH2T6aArLzrewLT8UdHZ4fOllsBf5L1T0cufAvX2WgKD66LmXuEeKD4db8Zwzx74lTBs8IMDJdAbC+zs+g8+gKs9F+LjTyh\\\\\\\\\\\\\\\/48QYrN57mr8NY+YmY9i9cYGearKxaMFQx7I\\\\\\\\\\\\\\\/5vssJr4L\\\\\\\\\\\\\\\/UlVAr3g16iS7pS\\\\\\\\\\\\\\\/DUu6eVZdLUqIAenAkEGTej83mj533rwIWBiYyjEOIYZIpLw3f4w63TSnkVFoDoAsh\\\\\\\\\\\\\\\/WkNCbgAUfMV92UaOcTlwRQF7QJCroY305vRsvoeKlJBwEZjYP8ZVnmVH0SkYw18URzU0GJEfiv\\\\\\\\\\\\\\\/wO07xJQ414dHS043fDh0UGSbMGNKnvyFXLoQb6Pg1+nkvYrNfeBdP1lDDS4+tpyJGYrFWTitjtWQ34eZvVgLPH0NWzbP8mxyGQqKFy7u9GUja56NPEMISg12fUVuY1Fe\\\\\\\\\\\\\\\/X1xA8gulNJF8jEtMlKtxG38GEeOUUrcy6l\\\\\\\\\\\\\\\/NsbKoW\\\\\\\\\\\\\\\/NeHQKrDSwyYew0JShE2kGU1AxR8qRTax3PZ8Y\\\\\\\\\\\\\\\/d2AOEbFv894R0fZQOFGR3oEwvjp1Iw370AppSrM2LLtNLdD4Y2yHitN9gyp12Qqzi1ogzgIvCNfUoc4GluW3VsJTgizQx85RyCQqHAQgC9PVdXjynyoCBFNPxtIqrLXpR19h0bZR1qZ3gORiyEzsq+gblBfFy2rreAUX1GWHYhgMHx39FzzfonwP2Pc9vNSfG3VL2NX31IvQ8q1mkPl0hyFp0YboKTaPOydexxl+ky\\\\\\\\\\\\\\\/K4xLhn1OcsgqXb+GUygshjxKmFXEu3qNN+VOoLrevUXve6Vh0lI8aq73bOo7oOGo6EZmxENqkwdkWACNY6+R+0qnwjqFL9LnP\\\\\\\\\\\\\\\/u8vOzO857MWkdfUOBiLnJAKbJhGfGExSsVdWwiISiQSHPkzvA\\\\\\\\\\\\\\\/O8Th2p6Ev5Lt3VgS1wZ3mMkYdFIVe+YF90LCt+j9bukShzoBIhA7DGhUux+sSGXjQ3PkJTedJWs296iCmJRnAHbMGucoFegFYYqYITPVZZAg4zj+qvNfAIiS57XOCYPxcITaQpOfarr+APqjObL9t5QWxr8nQYzW5fqj37xXfpxhEzpZYlyDDZTDIfL2A8KGliexUeBmMROOs6ghhXlev0ZJHgvl+Nbeo70ZA\\\\\\\\\\\\\\\/ylZKZP7akX6AvfENpDxDiEJYDkb4K\\\\\\\\\\\\\\\/ze\\\\\\\\\\\\\\\/tGCXuRM7B02ieucZr9QlI2mlZM1P0a46hHzUDMA8znnzKEgmxXOcRYKr6q3XB+OXBLHkPvfYCr5RrM1WXOlJtLmD4elyJaYXE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022iot3KDnhEMWb\\\\\\\\\\\\\\\/FMkoM\\\\\\\\\\\\\\\/SOg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00228b499786afbc02d0af208d5a1a51866a51aee6ea08726395d259cbab86c22d43\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/4\\\/e008179.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/4\\\/e008179.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008179\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008179\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008179\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}