{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022DXG5CQplyXzEhjy9reQvcRX9cszeoninfOMDH4y+Yf5R7TnhcmiQymOR2jeqQxw5s5EdGMlPUMq92a+Co1K+SqCrnb7uR9nS\\\\\\\\\\\\\\\/oMu0IWRLoNPfAwDQ3OsLjBSWTWBm8dT0EVNYtXAgk0AurafdbfbU9fw3K3zUwk\\\\\\\\\\\\\\\/rhMByXcS0YKU\\\\\\\\\\\\\\\/RhXhxBeuaW\\\\\\\\\\\\\\\/n+yM0okTWgNr6VCsa2rKoZiVJiI8riq\\\\\\\\\\\\\\\/TU5jIBW8v4+sijIPMCNbCJBx3FTVWtJFRl99hlgH8e1gucNt26Xstc1QQkkkpbEnU6xvhHiaTUT\\\\\\\\\\\\\\\/yipVEtEttT96qIxj4pNpzI3UfgEJdtDJ9dX\\\\\\\\\\\\\\\/gI\\\\\\\\\\\\\\\/yhqh4ZLlv0NrXTjWpsBeTOP0FtOzQAGn6erc8pUKqm\\\\\\\\\\\\\\\/7xB9au6HBBpFZMTBGf+zqsMFw5VvVJnVEP6MojTxzYnOe4IUD7UQXBLKRNzGdxJrehpcWRJ5ib4BNZXIRDMPBnmrE1Fa9AnYbd4eP4h9KyS6zVlMEHyL\\\\\\\\\\\\\\\/+HAfRe7Juyd8RABB2w13TwjkahzowxQsb5uX8WwYPIAgaZGl\\\\\\\\\\\\\\\/ux\\\\\\\\\\\\\\\/AMwkujKV9TSMpH7\\\\\\\\\\\\\\\/grpTwv8sCV\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/7ex8mOjssUQbnrAaTvPSWsjMUwQ7zrmWX\\\\\\\\\\\\\\\/Yl85xeaKwUzrhUJ21dtvC7+LPNYU7orC5ZPA\\\\\\\\\\\\\\\/+ojPQZXYcRbaq\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/uVPEXkEmp+Lth5KhvS7S6OOmkyFVCiV8cG6+j\\\\\\\\\\\\\\\/9CqMGmSyREUpgTV8ECrjP3BDOAXMbEyQ5o65bqUD+tz4mVkNdzQKd2CFtKNjBdcRD5FhBTrIypMO24aGq2AjRovWb6X+0GnByLmce+9fDVlWJKncT6JzApEiDUytGOiHfeGeLhPD6Gt5i4LtuscLmcU0fkW7VzqVtkM4rTrh0ajV4EmYijBnJAVx8FuKddr6sHXCPDNAS+gv10I4FV5fzEqoNZKvsfq9+f3r1gI1OGTHp0d96EhFD89vtyoRN09FU\\\\\\\\\\\\\\\/EEGI+NfnaDGlriMtCiGY1VZXokaIVMlXsEH59PfPcmIuMm0HvUVAR8Efjw0v6Tf2u78whUuGtW5xeMzHEzRb7\\\\\\\\\\\\\\\/OPhNDbup2ZR+KYPXkrESRCuYqzQnpmucqjcLMiw5YdJcw5HL7Ix3nCStK6f84IozKLyKlgWtYuKnn4rubRT7lbw\\\\\\\\\\\\\\\/uGGI7e3SsJ1nHG4y9sfDFocEC+VN8XqW96cjSWLMIgHRVcDmRzy+bBjw8rpHEgLu8lWot1qcgcj9ymPgQxaehUUrCMteMjcKj\\\\\\\\\\\\\\\/HG30UaRhv+J\\\\\\\\\\\\\\\/uR1gkN8VY43rjpFtXFnfPkuesedlHYn5Kf9WV5TR4LMJjg7lO9TRuQy90amvc3bO8EShDfsJLoZjGCrcFimqqhF7hm8s7kvs4T2xRM0GRGtwe3eKqjWoAiKI9Zcp2vkYSq7TeF4sc0ty9I9cc77ld1bhqxEWVA5TmrJvfKKD4peSDOTIniIT7daxepLM75iV2i9hmm\\\\\\\\\\\\\\\/66PiIGufFNbXB1sskz3Ur1LWjhRbZEo+VUNuJ4p\\\\\\\\\\\\\\\/hPcqacMSRWbz8Vv5SDUAz8suiWSO+4A8jh8o5FZc+Piz\\\\\\\\\\\\\\\/7Hx67UkNX7ylr4V1679e0tA2XRDh0rHjvdCje4wky3fu5W5xJqDye6znUtjYCrDadqO8uYg7NUlWEjtjctzkkuRdPcD9805TY5TriM0XPO+cSNhdHqJwTQtzfu8GcNgvaeKihzkzy9s\\\\\\\\\\\\\\\/s7omGTc569o78zXm0dsHf2ahxPRbfFM6iMOi9XGlDSeA2y\\\\\\\\\\\\\\\/qcp5aYGR57ozPf2po1MpcJY2N0QJrUKI8vaUqZZkOycEkT42SQUCl7aCS4eNgZNJ\\\\\\\\\\\\\\\/AZti1ehTawnfInlVaEkuRYh7uREu+kaMMJP\\\\\\\\\\\\\\\/8YjtOQN\\\\\\\\\\\\\\\/zxRKg5Gql9yJAfZaLo3771vhuqFkAoF+hBwDruCWYXtR54SXFmZHVYm2hToEZLz3XCtjtX8lPMLxzTRKnQquL3V3cPR0EJkyApAh5iPY6\\\\\\\\\\\\\\\/QNym6jMBBNaJqzNlM3ZGzYCKCFpN24XL9IRcoUHeGT0JiqatSHT7q\\\\\\\\\\\\\\\/ERQn5+gkRmCnXf1FCsQsat4J5g6xftSOl6\\\\\\\\\\\\\\\/trbrST3UJkdtbmrxKhL9\\\\\\\\\\\\\\\/GoNpbnk2TS2OS1vaMTPLT7GTwJ3XAEBahnsMpfhMup0uFAxp84kU1erztORVYymVZLuKolxdTBY2m3bKfMZhvig2\\\\\\\\\\\\\\\/PCJRXM8eaXqWYwBaKCtnh7noe02iiYSfW4gUqiUVOBbB+8AGmyoUwa61Gnq9WxetMCwWXef5xcaGNtbNKr32R6+uRjLVJSBzcVsGxqjg3wZqQKNhbPms+VyN39+Q3Bwg7HvQwjUgDkb1sMkPTbgy5uaaiydLTKJnJ33QG\\\\\\\\\\\\\\\/t4HMhbgtQ+9n\\\\\\\\\\\\\\\/Ox2tk\\\\\\\\\\\\\\\/SKZi0LVwQGBrVRPpc26VzAQpbQWTLwwY3tXQeXVzhFSXUBrOWlFPyao\\\\\\\\\\\\\\\/lVutHy4L0mxT9Sb5KqMe3g3T2TfvYVXQNVCl+hziCSaZSvK8PIAk5FEKpZyeJOQehSgXD9bCUmvAlnXO\\\\\\\\\\\\\\\/O9ODAntUgqa+8oAkyffhIWV4UTawXErXx\\\\\\\\\\\\\\\/kl17n+Rqk+eZmqZOXyAMnekmidL15LF\\\\\\\\\\\\\\\/MM1Byt801OB\\\\\\\\\\\\\\\/ur4fETimELN+OP4k8XM6v7vBSeE6aZTWlnQ4tMdglX6Zgdk465LsnOpxymb3MJ0zVORj\\\\\\\\\\\\\\\/m5hwzUnoftLc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022yCqzOBUtYfW0zJN\\\\\\\\\\\\\\\/PepNYw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022af0aa2e270297173863446fb2d6f57549240bb2e29a197dd34eab4d81b1a4c29\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/51.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/51.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0156-7\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0156-7\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0156-7\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}