{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022fPWksyjztZkeGu78B200Z95w1l\\\\\\\\\\\\\\\/eWm+Akbe+gu+HS8EOuI22U+PvgcrE7Ve7YUl1iZkD+jAP8a7\\\\\\\\\\\\\\\/xAw1Pvf\\\\\\\\\\\\\\\/QlTtpWxM3j54nJz\\\\\\\\\\\\\\\/d\\\\\\\\\\\\\\\/tCIVV3qyMLBbQFC8mc0W8xdIRuP2yu6P4Rwr6qPnp2Yualg8XhAxDjUXx5rAdor5SbuMmaUt7zpcGuLk9+UQZu2wjs8JogyI6iXpIrBDP1C7BvxvhTjHM3PzitzStNdJ\\\\\\\\\\\\\\\/gAtC\\\\\\\\\\\\\\\/YP6kryb5qQXh6u+cz2R6iaY0pSsyAGyG0h9mmtoHXYcV0OFjucjFYiF3pvTxH5Q2MY+vBLDur2pRzSstoNTrC2fe5qkCVuQ8jQFvDeRZiuf\\\\\\\\\\\\\\\/9NlzyAF5IXTlGF3rtLg82+uqh7IhZC9By3s7FdaghLOBf3pXk6bNfqLp\\\\\\\\\\\\\\\/MF6xIMuJLLAZu\\\\\\\\\\\\\\\/apSY8CbTtB3IVglJ\\\\\\\\\\\\\\\/PqK+cIRfhm2CMsz94d7eupXwdPwzyUUowBO+a5Dvz1mKelMkP513Q32PCKb7rmUtpAgEChIb2\\\\\\\\\\\\\\\/cPZNrIwqkYLCMMQU8W7UJDlFV3agto8X7jgkIOVHiQxzWWlhJ8Eg92FUOtQKNByxljVcniutkgJDoTSjWPqh+Vfm4Ix0c3SJkvhnD863KUzxpe8GNiCwytd\\\\\\\\\\\\\\\/y+ByZR+jGyKWMtPVhGk4gMlCLSh\\\\\\\\\\\\\\\/6xT75yjP3y2V6ionng8Mq1u50xUjyK9Rnv1msd06ahbj3ThII74bhx0oPVUkFGC8VMt+Zqb4VNkSuKNnJmIexunVlzWwYA\\\\\\\\\\\\\\\/ndGMMvh6hZnj8kyRlNiak+MFAMwKx3hncSOG3Bb7R91gGu\\\\\\\\\\\\\\\/6JAhCO6xQa6s3uNDxUtryAfr6OSYYSdQzkRbOvopsoV6Ug2IP5ZFq0QMBYlm7Sfpkgr6yiFczbyb3s5kQbrKRGg2SOAAPUJ1rq4nsi4XVQW2GzoZ7NblVy\\\\\\\\\\\\\\\/vEb4JWryPrdhCH7wRyIqGXPv4gdaLe15hL1mjjAmq5RMElfE+kIswDoKAwQuap5QcARillwS2Dl6v5b4swBVg1N4BenXawvBecboJyFBMm9MHf3aDESb\\\\\\\\\\\\\\\/P0a3YkinOnpJtUKdYIM6BxYGVxDwSwDVg6LzqmLgJCw9\\\\\\\\\\\\\\\/tmvddM3TFd9\\\\\\\\\\\\\\\/x3en2F\\\\\\\\\\\\\\\/g+LMCPi7cvS2O9wDvGvJF\\\\\\\\\\\\\\\/YyFosvErKScJd8Kh84FjhaXf7eLsvSY0BECNRift2HkqxG+uL1n1XQ8lROIET+mWPJ3ztAsg4DPXg42g\\\\\\\\\\\\\\\/StAz5SjCY771tWFG4PEv7C+AfQM65sxRIAjA\\\\\\\\\\\\\\\/n5xCJxh6wZcgnwTq3ajatg2398R1uW\\\\\\\\\\\\\\\/dZkgCPhz0NCqdFPd\\\\\\\\\\\\\\\/Ow8RjFjyn0vk\\\\\\\\\\\\\\\/NY5E5DibuWFQvbXnxxwvN8NFQez2qIJjYjiov3I3uiv6FVRjQl8\\\\\\\\\\\\\\\/EyoFvT6RNCJFuezsFB12pwLKSsB6J1I1AWi3lLCZTZl6UZXAlK3oPNIlirmMURJBBQ7vKFwF7eFjB02utLNKyWmO2fxrtlJg+74UHrbupyCZJ0mbSqex3MLlS\\\\\\\\\\\\\\\/9mDYDZhRCL33hzrlOgk4HoJ9F44CRvVq4TmB0\\\\\\\\\\\\\\\/0ZYXVpEPHkgYrCK4c2tY14+XeuUD30XZJy8seZDFS1Mka9bGA\\\\\\\\\\\\\\\/JdQDABM\\\\\\\\\\\\\\\/BQcAz5QsOpGKv\\\\\\\\\\\\\\\/QS7jGAEIzz0iZyzOSUDoC4LPR2GAAQ6Hmv\\\\\\\\\\\\\\\/DeFNdqEWP19X3dX5mPKECeDk9aWLjVW\\\\\\\\\\\\\\\/z\\\\\\\\\\\\\\\/QtuiI\\\\\\\\\\\\\\\/SitNObP9Ud6J56jDck4DZUq\\\\\\\\\\\\\\\/OHZz9pJL0+q\\\\\\\\\\\\\\\/2WWj7dIwmoICIgEwZ9gF0qyEp2qGV1l6QqzF\\\\\\\\\\\\\\\/Isx8q\\\\\\\\\\\\\\\/5QXUWUoPlpEhsLcxfTCiUS8TWdTZaGYfY\\\\\\\\\\\\\\\/Dgdh3GKNglGm+dESFNNs7rW9NmAmYeCKTOcJslTmAvJa19fTzCMYIthQwbl+yqSj\\\\\\\\\\\\\\\/DKxllkSOrJnpTwyYezA7X8eOcx\\\\\\\\\\\\\\\/MYHvshSb1LSemkLCbwEPgnd3Dqi\\\\\\\\\\\\\\\/jF4qYPjZUQ1xA5IT2CrCbTfDL2uNGGRhatbw6OGbVOsxdOG+TKJ\\\\\\\\\\\\\\\/HjeB2Gq+whh+UAANE0RN5ZTiiH2EFuUd8v4B65xMFGeBD6MCgjNTHqdGedtUzT5k1M1Mve\\\\\\\\\\\\\\\/e\\\\\\\\\\\\\\\/SI9Zr68zWI7sP+9dj573oZn17UoZU2f4fQf06jh9zdkTXDfegX7rQoNji0Zy9ZztRGkY352Km8YmqHsrNcfdp8VUQA6iWY38Fb2R3818d\\\\\\\\\\\\\\\/dUYR8tlRlBhZDdPmPTLJ9OBa9w2PI1N9NsM3HudTnIcne\\\\\\\\\\\\\\\/rPJwz\\\\\\\\\\\\\\\/VYQC4WeTSLyiN3SFfLd6575JQKyLyRF8ZN1pIMtPE2U0+RDLlSJKiIzngXnXkzQiI4gRUSf66Sskpywirx8dI8Q9uRh9GfXkI8XNyssjZPWg8\\\\\\\\\\\\\\\/8u9owN3QftXy3lWBBUFx6qP0Mod85n6n9pz4XU1EJN4vrAVgsLq04wRUm5y5YEO5UIKNBld8tOrAEgHvtBVqCLPJGnQIE65XSE2qDKmma0vwE4U6IgmgAINLAa5RwlX5YU2DYag4uuEP+6DGw6ICUJ8LRLqxB6RjljXXOn0iXxRkPTHfwiHPtq3QQFczFauuTL4CVXMTKHQLkiQVix6sMdWl8yGShixs8fUV3zQSaLcvXETdCorI8XxUWYiE6M03vSkbLdK0tW5O0QdUHKe7LEjQE5vuF3gpKwJ7fSZI5ZQ1xb0enWiNxehC4hvMxsbX0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022lYWkvWdX0HiolGMzOZkGUg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002244f701a649e332819a6951beeec23a0e865a477d237f1626bf7539ecd23976fb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/81.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/81.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0180-7\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0180-7\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0180-7\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}