{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Kk\\\\\\\\\\\\\\\/EIBLzK8ws5sGt0Ul\\\\\\\\\\\\\\\/BB8Q1XDx9AQNbhwYDG4DwioqbmTRRKOtKJEHLaTVyeWn38rdX+Z2sa3lpwAexE3TKIrIpUkUy5kcRg03lELBZeGEV257bjEZDLB\\\\\\\\\\\\\\\/Oi4MgZewOmpSkzEK117Bdxnm4OB6tPBo3PSnb8O2HgXye2lDW+NdoTabdRqyyar21PCHrZtNaPXquPmEzDoS3h17N7AvXfRk6fDd79n01RmpRYeArbEgMs7yGPJOO5+LxqBVHg2wZ4EF\\\\\\\\\\\\\\\/SNLXh0ZIv1IqAsckf5nl9VkJzWZLX5pCUjUDDGf2tRI7i\\\\\\\\\\\\\\\/xnwm46\\\\\\\\\\\\\\\/L5iCSzNz6zG7KCh8GRS6ttuP5hTdEYp2uHh08IifgCvSiSNJMAjldbigo7PxkxkQ4kXnUKBKwgCzSZPzPHtCQtSa5mw3r3sA5HtW42lx1XAMNDbrP1mm6Qmv9kiDTOoIkLS\\\\\\\\\\\\\\\/IaNobXb8us+s1vuYnafbIs9u9Gb9tJjcdl+4c9BEr4TKPyQ64m2ROjgfc9\\\\\\\\\\\\\\\/K+nvMm6jZUwUkvugeCKN5U7CiJKni5OrGHXDG\\\\\\\\\\\\\\\/ZiU1s6CWdqKjvQHwID+S6LecMo3p0d7wmsmPghe6YssnQe\\\\\\\\\\\\\\\/HHc\\\\\\\\\\\\\\\/54URI5Tm\\\\\\\\\\\\\\\/ezNkM55hqwdaakW+YmB5RIOcMLwRTHCbSxRpto7PNWJtFEVPVuP6+OnsyNPYqy2TLbcoDOOMoHNgMOooWxR25q4Q2mZfgUnag96FuS8\\\\\\\\\\\\\\\/61xwKR2icrnyKNbTatxcUqzUxJqyvb19NKTFKQe\\\\\\\\\\\\\\\/fjlagWglfnTnhBjNt1iZhcrYYpVlZ4udYGwLin+IHuS3JOhmRuEPVhc0Vl2ZL+XuSmWjEzBVT7FgKnDngT\\\\\\\\\\\\\\\/HR9Brp1m6xLTxX9HUBw97RJ7bMIZcM0yRwXWkXPDxAmfBm7\\\\\\\\\\\\\\\/NwueqrArviWHKiZnVBg3kJ0NDxxeKeyWHtQUqPObap2ChOk6EX9FzWUnqaAlT3dusrEfu8zsqiXfr897jKSpt3F5nF9dXK3sPmR5\\\\\\\\\\\\\\\/R8ANAjrv9RH7TtzpTQs5Moqov\\\\\\\\\\\\\\\/R\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/UIWhw0zrtUt3PdrG6XcG1tifXBZ83LT\\\\\\\\\\\\\\\/6TzfFfq5T308YJKH5pKP8UzBiDxuz4I5Han0lomxINOl6C6jyUUtzUhl4RsOey68+xX3kCeMYHLwU3jpSyL6vAj+kjUZe5mb0TN5Z38cvQw0Euy2MEjon6dYXXDRt5erS5mPFJrg9PFZgYr+sgEeX6laC\\\\\\\\\\\\\\\/m73rTVAySlhXLHoxT7tVOQwtV\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/4R\\\\\\\\\\\\\\\/OUIPkCYTrsqghTNqgwtH+Iov\\\\\\\\\\\\\\\/rAdql\\\\\\\\\\\\\\\/8nY9cq3txoCjZs52ZXDhS+ZDii7QaEoyTnv1H7KPg+84Lpbz2FjVjCVuuxSgEXAj2XldzhycqEpFgtaPSVepGStwakDqrv\\\\\\\\\\\\\\\/KECL7N\\\\\\\\\\\\\\\/W8FMD0MMFum0oJ+eVvCPsHdgzLj9AzM7+fN70TDI96\\\\\\\\\\\\\\\/Oe5X4hcCXIvAq7D\\\\\\\\\\\\\\\/wRFXELbVe46uYA\\\\\\\\\\\\\\\/0\\\\\\\\\\\\\\\/5g6+WhKLn7Gxi5Eb2pnI70UU8VX6LvqY\\\\\\\\\\\\\\\/4riVnO7rz6mfafKDc010QEfcVnvenaWyHfkTZKPNZ8Q50R+kiY3jS2hrRJ6S1fJ8YnYD9eCn15RgpKxMk5nP77nHvkh\\\\\\\\\\\\\\\/d0no9tebAdEj4VWdjgnI6WnK0yyfjS\\\\\\\\\\\\\\\/q172Jp1R+Mu1CI0uZaX5pIGmSa1XQai7Rqo3FjAdniibFhnQDeqi4jhKq02MwQ\\\\\\\\\\\\\\\/Cdw1BSpimX4KnmvM8vdG+u07C9f1jbGo4MC\\\\\\\\\\\\\\\/I\\\\\\\\\\\\\\\/dz7Dbvuo4OBTwtFiEEZu6x01fmrajGf1aOxyO+J+ADb1htRukkrBWvR\\\\\\\\\\\\\\\/x7OCZMMly3O9QLATQneEmjN3\\\\\\\\\\\\\\\/N0jIvTWDTcsgMvSjZSMF0h787eoC6ssR1DcpoABInZrzTihPJ2bjKc8yajtk9ue23npOgCaHVTMRNNl9J4TjkeYCELKt7MKA5E7q0CRz0E7UTtGOut+P+y5JOB4pknHcd9+3Bs\\\\\\\\\\\\\\\/v1DjJrzcZKsnJ9fiYQyhSq35f5g4Aa8c5lgoPZObu8zkLNZgnyuuwXJcWXthvADu\\\\\\\\\\\\\\\/qYNUNsAKZyAFpfA2EUUgtVWIIPd5Sf5b5m+ihX03MZ\\\\\\\\\\\\\\\/H3EpHEoaZadnj4lagzUxU01YjUw36ho+fHx4e4nzs8uQgG\\\\\\\\\\\\\\\/uBUdIEf7ZhN96Mb7Mv8ueAoi4CTVFj44gk4\\\\\\\\\\\\\\\/EbAJcitRtQJlKDe94fFxWuN9689qIxZhEg+grWNnYOHkhxKz42ZqKYFWRscZw5k6y9jWBl6yUYBJuFkNKjyJaFnSEZv5JX4v2\\\\\\\\\\\\\\\/bJ0WwdnmlOBoHCYq8ijAoXsbEuC2hC3yP2AQvD4QxL2YgqrEdRYWtO2Xnfms\\\\\\\\\\\\\\\/rItXF2te32BsuPtRr0IRTOZkXZ1dW51hhsKDToUQtyGZ2d4aDdOU2h9\\\\\\\\\\\\\\\/jsDOSFJnU5tONTaBi7xPQ4+n5rU\\\\\\\\\\\\\\\/WetqEY+LxLe7h4VW+p9fuNBVcdivABRB7ujwLjZiWg6iIWYYr0sEVqluClqwbBf9TgU0pCcv6KzUD0geYFVlnj0oq\\\\\\\\\\\\\\\/4t+u9ehZhhTJqcnlDp6G9bF7OWGjjhkQMYjQ44twOtA0gDyQyyAmMEXbHLlnBfiQz\\\\\\\\\\\\\\\/zwA95ctbs0SkPS3BDAX5vCUq4P\\\\\\\\\\\\\\\/5MWAF6ukXGfRZiMRaiLE5X9egmwqxpICg09Krr3A8KanIahuQnRqC01BOw4SE\\\\\\\\\\\\\\\/Du3p1JzpVfocZvtA1s=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022rPtIoczaEIGsYvL0JyM2Pw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002242fa95ca11c7d1768c78d8f91002bca86e55a6dc8ec12ebfcf18aa69a81a6088\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/30.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/30.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0134-0\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0134-0\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0134-0\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}