{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022299VH\\\\\\\\\\\\\\\/4JO3xDIQJH8R09JpKHf\\\\\\\\\\\\\\\/+nZ06+V\\\\\\\\\\\\\\\/tWspNZlRvyWGoteazoQuPvdoYDkEZN83Av+F8INe\\\\\\\\\\\\\\\/FDvw8VoOSgGqR4+q86eDAU4LdWSLI0EUAwMdBkjJsc0K2Pdk8tAxWK8v+SoB9b4UHd8eSVbfgknIBJEVeLaaO2XwQ1Vuim\\\\\\\\\\\\\\\/TuyKtlb8TnxfdCNLjN9QOB7XaX1oDndd1ZEmP3y1nAKxh3OrfxEhNAKMyDp5msdAuld6BDx4DeHIwCw6he77Zd8jFih1Aprc9f2Gpm22z+PtQnyXE9zB7coG\\\\\\\\\\\\\\\/wcCy+9D\\\\\\\\\\\\\\\/THMFSoapfq9Z9tFLoEn\\\\\\\\\\\\\\\/UwmQp+49fKM41XYoJIQp3WDG1YLVLjg9su2DZ1TFhrJcPbEuN71+hvsjdkyWGjhj2jTjb3u2CM6EVCE9M3Q\\\\\\\\\\\\\\\/5ZNVloFTuhfa162p\\\\\\\\\\\\\\\/zqr7djtmJtJMSvuYGGVM9PW9Q1A9SPVQO28iKu0W0F\\\\\\\\\\\\\\\/z6e7N5zPCp5XcRrPuiPcL\\\\\\\\\\\\\\\/7gxZTB\\\\\\\\\\\\\\\/CJ\\\\\\\\\\\\\\\/q0SAZ+Y62Es4yOrwrf0h0LsK5ZD3PDmTvpDo7XfR3g5MsCgGyHwOhBvvtj4ehulprxWwTdEsHYcLEzk4rQJGLuPgK2s02lRdsXIS1pUxMq4GlOpItRKL87ANl404x7gq6pMaGrVIoFxJP9I2uMWOwUT4EM06q+bUOcnxWzRloXkgXFEN0MfD\\\\\\\\\\\\\\\/tgJZn+Xt\\\\\\\\\\\\\\\/d39G3MyQdb+NoyJaIlr3EoGLGuoDD0Ue\\\\\\\\\\\\\\\/+IxdW3NC5HaMnIr6DbYG7FctGVofvroqU2DSMFFP5PvQKpVruLykqr6vB1q+OoP3Lk5isq3WL3ezOcleAPBlZkJQ57LaKBxSL5VQ6gK14bB043CBuZJzjKY0jqnR05Wc6aGW6r4dusIhsHOP4jyY8OA\\\\\\\\\\\\\\\/foi0Lk0TwR9whuaZ1\\\\\\\\\\\\\\\/RCVWAqqq\\\\\\\\\\\\\\\/FyRAGPKA2IHuSP+uPNto+TULyOXRmxmfI+cVF0EplKba7ZXxesspRbkOtvngQqvoUaQfyt9CYAoadF3HaEB+Vf\\\\\\\\\\\\\\\/wH8nozjgtAhbt1thVOEq3uNklrKKfSlzWXOnem9ZJRqZwVPu\\\\\\\\\\\\\\\/sGuwkCot7yKULX6xllfymA4UVELfUXt5rlKysQHGUwkJwpNUy7YV+wuHjx9I9yaVART2er6udUPhvsXFVZg3ZyTj05iov3tRyXsVWl3iG714KLE77Io0KZ5AstWahM1Z6icwLhyhIqQIIsByXDBH5Hxu7bFbNN40f5q1dzbvT4Kxw5XWnRVA29m5AXtFpN3lzxaFegjV2U9\\\\\\\\\\\\\\\/GvTkpeVi9Uua1\\\\\\\\\\\\\\\/RZ3b43nnDmc+Wy+zvczaDxRqjZ1Z5BiRiGCv9am0XbkFMQ9LEfR9TOl41W5WCyqedIjyArLbrxjG5jYXbAyZ3FHVSNuDB4SVjsf1nU3c8DUXo2dmCT6wX4cFsHyGYhO1tnVBuruOBZVe7h0wp9bLR3CJ8JsmEG6UkQbRiCA68cnC\\\\\\\\\\\\\\\/ZdE98lUK\\\\\\\\\\\\\\\/kGMQvlRT+zck0qCkrl\\\\\\\\\\\\\\\/Iu3QKVjlK2lyJCoHAI2Z5BJOKKIwI0x5yMEq9SqK47xh\\\\\\\\\\\\\\\/EgmMYZZPXj+aVJwqk\\\\\\\\\\\\\\\/2BWYG86LAHJZp3du2yxBxEtYF0yrZ1+rFbidv54YkalgZ18Y8EL0HdrxdyV0QJ9g75OqnzwVJi6Kp\\\\\\\\\\\\\\\/sQqyCqwUgFEOn8N2C5+yWdjfWwyufEN3gPPSCgJKKdsiJezGo+1L4WytAi9fRV8lbfCQaDcdUqqlakkwqMXEqrWjWv53sIFFhM6D\\\\\\\\\\\\\\\/xmso2b4RgyF8Q99Ll\\\\\\\\\\\\\\\/HXDzr+cmSDtLPGgS\\\\\\\\\\\\\\\/nBR1jMMxPPscAl6MI+DlqYYO7HFSXSxMWXDR\\\\\\\\\\\\\\\/f3bwlmF+VXhAIEdtD\\\\\\\\\\\\\\\/X3c2DIz7gaG1N6B3ynu9ZuOXeziPIR4rv25ZgYtwLWdqnNq8GKIel0Ycb13fEhrTT5TTXnQaeGSdkNSikgLMBJhzWoPy9yF\\\\\\\\\\\\\\\/6p6DXLcg\\\\\\\\\\\\\\\/uqOV7ZCdjQDffOaWbBOm5aztjEu0qvxRDUU4emCADELSBQAzIqYBY39KUKlnoR3S0PBuwyEHo2q2QKKxtfnmEnTGMQwpyWNLckcDq9TKDgbk5kdpggMwqpkNZmEXcdWAlrSjL1tgYLzhsKmtfTPHcMDezdLQ7YmDkbqSmxeKdaKM0cBEs+z8IED0OphArATVzRli4FlXlWbwQyEOMjrtdmykUdd2kL6e0Xo014h9QTkjkECU7wDDDBRt4VktUIfIYShbb2nMwnCakxItD0\\\\\\\\\\\\\\\/Mw+v4ALKkkKjzjNm6Iyk3WXGtw5p4VXfPamc8Jqpmn9NtIg+euqdonJF7lYMCnbwk4PqFHQnJEoKCmNiORhBWlQurhQiKNZs8XOmxl3M+NY5nfaO5IqZomniz43sHG7122AqjjImD32BeZmYZ6HAEn4yHf1xMQBPZhJhpGGR6NTjCG8gxFsPYgWMqnaf4Xy7gKFUBlB866zqIPn+pK5\\\\\\\\\\\\\\\/XDxIuKc3MNIuuOzvSnPSPoWT8ktOjMQLAQrSxYi+ruSy5hgkI5q6O15vo7tDDsrad+Kxp0bDVqkMxNrtrSh00y9TAcJlFHHzSLv1KOHTx\\\\\\\\\\\\\\\/QMwTOawS\\\\\\\\\\\\\\\/9UJoQKXodcbOFuNiwSIWVJnG1Z76eFyKqZ07ArMXD6tsbBvgxOV0J7wOUEOTBVQgvU\\\\\\\\\\\\\\\/tj5aMBz4zEQLL8G2c0jrxMH2HjSzTdelJ+hqZ6WElf3Io=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022ZQoAjC99OjIrxbIHPPHNQQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002213632e23c4c82452565bb3f8fdcd1fab1659d3d927aeef247af7379c332e47e1\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/2.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/2.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;4\\\/1\\\/2\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0106-4\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0106-4\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0106-4\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}