{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022jT6CgYo4eaQtDvYU8J6i3B7GDEKZ4NOMk1ZjRKVL3LADMEZFTlGJtch2eHEinO0KfTiOtGURNNWksR+ubDrpkV9QQFm7ZPf41KH3xXogcIou8IwDmINld+3RxYG1cMSP6MbiCYV1dV9FaJ0ntIk5tQAnH+GDjrmI7OaMw4lTN7\\\\\\\\\\\\\\\/ANBuGZMmbyUPG+oqKtCbM8BWVRDXNzhnaeq8FYoGiifvFip4jqwgvnKExXyA1MyKyFLKAsfwBIwMy+rB+zVXlmPs2CLftMATFruJYTvod1uR2WSyT0o\\\\\\\\\\\\\\\/SDymQcktkGnIyxO\\\\\\\\\\\\\\\/YGOoxGiK7l9C2EZSvY68TESk9XO+HFbZmTP6\\\\\\\\\\\\\\\/ipeuYbORasrg+uojdRvbYIk7a0b5ToZUo59RU\\\\\\\\\\\\\\\/O7ujFqCK3DkZ9QAokxG\\\\\\\\\\\\\\\/qish2RQT+tR3i6p9dzupzK22TAlpneoXepX2Df4x770z7BJTXZ0rHgwfk35IQk8dkCmLnd4FixOoZLxe8UsN5gUMdNZncqFclSireZwwFVIRVaQWeeYr5Noc33GehfwfZy5tkZ8mam8BkUKF8PtKokxEaI1vL7pHTSlcJTxws+qKFl9FfejLkJ3gvNzTMAlmlEiUOwayb+1M50n7MQXSdtLId1pT1vOd1FOx0FSkPBAoE92P71BR4fT9bU6gEDcLcLR3DTDRpxKcB7T0QI3\\\\\\\\\\\\\\\/WDeRmEyLqmbPLaXRmxgrpA3Z\\\\\\\\\\\\\\\/uGz8VdU9Sp68SlQUG+SPRqbkHMJzsM+tSbOzubN6u1gFik8mxxj+XLloRaN3qtVFnY31aHja29L+cfO\\\\\\\\\\\\\\\/KS\\\\\\\\\\\\\\\/hke6CYWTjsiE6up8eE+adyMHm5\\\\\\\\\\\\\\\/cUY96aAgHgouGevfyY58NG93kyOEEkHxKrx967b9iFd\\\\\\\\\\\\\\\/IxHI9d85FKIXMGv6lqaY02X\\\\\\\\\\\\\\\/+JGyDkTw6b7FXBdd1\\\\\\\\\\\\\\\/Rrv4Uo8f25Ht\\\\\\\\\\\\\\\/8lhF5ajVh3Pik7zB06hHM3xooV\\\\\\\\\\\\\\\/fz8J7+Tv\\\\\\\\\\\\\\\/g7LqB680+33P9rW0gRp3wUA4QOrWtI+AACtn8dZLhNDgINLjJyjEgKKzUKqRrOM0PguCpZTcA+2\\\\\\\\\\\\\\\/mmbd0e4lF2Y4IVvWiPqLP3hDXu8AfttrtEoHh6gHWYvi\\\\\\\\\\\\\\\/S9pqOaWEND1jqqMvn1iHst7UtQNUiHxynMAt3ZtPGbn4CqcY2+V7mp7WNCUqzEWl\\\\\\\\\\\\\\\/+AjIZ7VpsILSwlMvtou14M0lJxfycBe\\\\\\\\\\\\\\\/BPc\\\\\\\\\\\\\\\/L0pbGoUlaLX5seSiT7S77\\\\\\\\\\\\\\\/HOjP7qn8dOntECZBDVh41zCCIYKRPXhu4bLU1WRNroZSkV2PASVae\\\\\\\\\\\\\\\/iGj6cdk\\\\\\\\\\\\\\\/4AbiShhjMesLj594WwX+UAJbjDT5py44Y7+M0jtYKsqJVqj5dnbQsRWSXgX5hNe0eTH4NI4hTryfZ1EHuK\\\\\\\\\\\\\\\/DYj2dXxNux7kvvo10B46EdeiKZf5zAtfYKmhSW9AlbAS3OZRR5yWGu2NEv0cS8RKOw2sj0+xnD3rGNQ7BZxY3+jctoFxdxFUJBua2sli4TN\\\\\\\\\\\\\\\/yySEbYqMHlakTYah58HlpYGJaPv7VJ+YEw7mJWcDBSGufUDkiKN0379i95Spx\\\\\\\\\\\\\\\/h6FOIc+1grGLZ7\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/lsDYwv8a6b7i68T36q9NdgEjs7p3SVf5RZPjWYDYH8BXniMGWgbsfwauUFFOlMKR4ah7VXQ9UmTacAdRAPtyF\\\\\\\\\\\\\\\/ky+x8qCBUWx5EswUte3x0KHAmEnPOeRk7YtJP+8gJqSALHKERg1Ls04BcLU5EnT9Ov1H6ISuwOebn\\\\\\\\\\\\\\\/TlmGTF0ywKeJKU\\\\\\\\\\\\\\\/bqrnKFAhV0ENqmUz\\\\\\\\\\\\\\\/JpGlrQNkiHuCWYbjQWPxdnjnzLPTuu7T8kQyW3XjyVMqFquC0WL4Xfj+fjdYp158CA6kKJxGF8rcbaCXzVg10MQfakbFmXxoAyLij\\\\\\\\\\\\\\\/O5Z2pc\\\\\\\\\\\\\\\/jJUSZa3w6Uo6qEwzzrvyPzJ1KfT5E1eq5ZG8MJQ1O8L434o\\\\\\\\\\\\\\\/GtqlmDSyy0CxQmZp0DDe8X36L4AgfM0m8UTuzmN3X5VJt2Iw938Fv2cGcrqg3LDER7eZyUqFp9t9IH5ct3KYd+RjirvfAvP+0t5OvUpBS5OuanB4w2S0hhwgr3dn+Ntxt54fWmK5BTDREPzfoZG08GArH5I6zjtlpxldQFRsCZ7z5XWUebaGnkgRoL2V7YLzR++MhAdgHpbkc6F3xpTj+sljD9IF2ewEU\\\\\\\\\\\\\\\/+Zs6fowCZEi6RN2PICbs+U8uNn6PiQwEeKLxings79nX5ZyiGBfPoiU3OR\\\\\\\\\\\\\\\/rMw2PVpM4d0Drr+\\\\\\\\\\\\\\\/Ppo52afzZPtc\\\\\\\\\\\\\\\/TYmmmhRp9jlVIOj5U4rx1PQrOnafa6\\\\\\\\\\\\\\\/0l\\\\\\\\\\\\\\\/s+hPln1+19VHyqUVSlvUgqpUBAbKC5pZP3kaMw36rPvjzrEVbzwR6zRRWm+JWv1h4OcKuAtju1OZHhWO+iMRjD8XG783cY8O1BQBiqpmkTc2rLtwy69vV3L4JCR5v\\\\\\\\\\\\\\\/8OWL92quBIAls1PDt5GiK2FBJpf9TAnHQMyspwzKHoVorTC33rh0JuY9zaH3uVwTUP+CQV5d0pxey46rpabsRWBh4EF39Fw1+UjjloMZP672n\\\\\\\\\\\\\\\/tEAVJAowc\\\\\\\\\\\\\\\/Y+kiL4X86sJM328rPOSPf7c0wuuHvTA6Mfa8LofW8XM\\\\\\\\\\\\\\\/MUVQFJCDVJKJtcbFgmKloeVJUO62cylJBzsHo\\\\\\\\\\\\\\\/euSX9PksTmGXIQA3K8+Sm\\\\\\\\\\\\\\\/IKcvHcidBYClYV6DDc3Ez9clOAKubtl7Q=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022PV0NtWddMMIwV7MlHp+LpQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221a7851fe70aa860a4db48692dbc789a9c3760bcfd0f401df1e3e8496d32d1564\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/4\\\/e007716.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/4\\\/e007716.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007716\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007716\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007716\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}