{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LH\\\\\\\\\\\\\\\/n2evFRigXtbhhQMxzKASY2ii4KXfRnLtEzmUa9LEqHLWqr8vRg8ymEaU0T0mfsLqit2i0W+HU1gLX00iXXvF\\\\\\\\\\\\\\\/yB51V+KYVRvMpgXecWwgEFuhJKGLxecxbdHRnQnKcTn3VTSM5eCFjJQBUKVZB0yn1OhSjunyZquojzXBbefJdsSPQl9h2VOuuXOncBNeeuKOHM\\\\\\\\\\\\\\\/YKnRb28MCQ\\\\\\\\\\\\\\\/eOo\\\\\\\\\\\\\\\/B+gYsIVxNJr5bB1Evx9Ng\\\\\\\\\\\\\\\/1HPrciIgZv8c66ytWHSMRJdv3Fwqq6iUnYGR\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/J4vIxjomf9FEZ4ed7aHx0W+Vw1VBx4wFsARnfK1JcgZdsCeunOX2k1Caxliarqugy+SosTuF52tNq4KoTBHmAPr35zsLO63wGyA+ikmzwofYQ4sGia2bkPGKiM2AxyD0oMrdEgMMnkdS20mLA9K7w26HRuWHwUQpHF89gbARwnktj0MizqWm9yujdsOD8UnluPCEC5\\\\\\\\\\\\\\\/Bw322Mr+Vi56W8O4IGpGfPOkM1nH3pw44Yt1y3E+SUrOAZMn8ORDvPp7BYHPUp3oTOhzUArm0nswC6Jw\\\\\\\\\\\\\\\/7TVXoB00hUNmQu5\\\\\\\\\\\\\\\/BE\\\\\\\\\\\\\\\/27PTmkwhp62ZBz\\\\\\\\\\\\\\\/Q3oXis\\\\\\\\\\\\\\\/byXzjh\\\\\\\\\\\\\\\/LWBaNpoJZFZE0WR8\\\\\\\\\\\\\\\/k+vfTYHwBh\\\\\\\\\\\\\\\/RL9dbbsDbf1OcyURtps+ohPaJ8Fsil9KB6yMV5++XKOADDmRG1kOBO\\\\\\\\\\\\\\\/3XN8A0dNm7VH41hjjJjqXFdVuelp+h5cBIJvH4IZpO+rPt\\\\\\\\\\\\\\\/u\\\\\\\\\\\\\\\/b+fNk6XPP8nJakYgl1REFSnsoqeXbjIhTEPbm1VDrj9\\\\\\\\\\\\\\\/TB7VGAtpVvJOAH8r9nipMdbXy9ek2Q6RtsoHFukBZSfRnJdyEJfEqM4GsuY596qUpOdPYo7mciAwBqO7arQlh+vNfXyiUTx0g6EeWjHrmT4DxzRd\\\\\\\\\\\\\\\/xzgahKoWBTDRdMMw43kVwafDiYTqd4mVxgHtSuX6RBDuuA6X2u8x93q\\\\\\\\\\\\\\\/VZ4ZhQV5ovHDAbTNjt+MzoWicWP06wE82+6y6j+QVKUrREHkpRZ1wnP46geYhzzKKuG9\\\\\\\\\\\\\\\/h9U0PURev8gTXZ\\\\\\\\\\\\\\\/miGYEtfS0kH27bLra1bwvW8Tvhwg9kZmIUWePIxwMlg9cut58UbAl+hHVotRVqVpUSPlfNxNTV+kwg\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/n7quXL04H\\\\\\\\\\\\\\\/ytc9i00uqc2lFbSit44LXqV2b79jTMxmYquCo9JxU3E0hsjLu4iMUo\\\\\\\\\\\\\\\/K9Pr5NObBwJLN+YR+xP8YNOzJ39WMVNVeztdHvoxsyzWr8rSQxPVOeUxOIZUIOc39FwV1vV8hAhRjwdzMpW0LbG1++KjlVQbsGqS0uYkrp\\\\\\\\\\\\\\\/ReDsDUIqeibSctDWpCz8Ard0QWEUS2BTWcpowv5l2nHjk5eFsyT5rmNm1ggz4Qwd9fnfjCXIHJ6\\\\\\\\\\\\\\\/4oUlXuQyXBXOjzp66vLZZkn\\\\\\\\\\\\\\\/QmtdihlNgTN5WblruEf12Ae+3yyEmZ9V3qsw+af1WlgKcrXcYyaukCgKfJ1lhpOom\\\\\\\\\\\\\\\/7c1gWV5zXqykBF8UIv+U3gopV2\\\\\\\\\\\\\\\/UgsiDupejp3kQ6x+cNFf71uSd8AarBzX7V8W1mk7ja6BnMWFkNeL6ijGPOLUUocqXH91Sp9aCayXE1u39AOWq+gg847y8qcBMuOCCYuRwNFakE6snKgmz53DgAzrGWG92L2uCIvXxDk1d1ag4+NqPUo6\\\\\\\\\\\\\\\/Nw2dzaqmPOVI9sZzNC7s9i8gB1jiFQVhSLJiSa5oI63lB+oR9fHzMjH92PckZMCmpBJh1Skc\\\\\\\\\\\\\\\/CTffEd55YCcm67ErokRWuDO4ytlLT9xRrZZTH\\\\\\\\\\\\\\\/GJo+9IZfqhr2\\\\\\\\\\\\\\\/n\\\\\\\\\\\\\\\/AdvmTNlfsZr3cJbkY9HvQ\\\\\\\\\\\\\\\/EpQPjfBq0Z5y6Rb5K1DfPtDAIRU8yKxayrcVsdWwTy6CkGs9cVCOAOGYU6fjasVQ9pZXyWOK7UYHdKMjZmz+KSoHBOza0ds1ol8HRps9fKvWt6TwGX3DwY8EsFM1ULjppFrHSFtIJFalyFbo6+mVvzC5J7AhkUxO2Sr1R4zKPyaOVOcylLd7Zin0cPp+2\\\\\\\\\\\\\\\/4f5NcPLEEw6gb8rLZx+MZVQrNGBs5BXlvdjxfLRV9PzLnYkNvxQdntk9l3PCsf4CU5qWOhPgKuxZtHWI\\\\\\\\\\\\\\\/EIB8Uy3egJkKSI1wYc50MY8qWCQuj9e+0eOXYx\\\\\\\\\\\\\\\/mPREulbswlVWVf8Ol2GPP5Z3fY2036YzI3SrAGGbDBx+kgNANR1iiV+2BxjM9sIypQh866WxAoTDdlldsRf9RctzGov3OBxFaBs9uLpi1S\\\\\\\\\\\\\\\/VLS2xMdihwUKhAU6iwDtho42jmO8DtueZ4VmDpoJLqbr4omDfFHhPP9ruA5zIvoGO73dpaE7EXQd6yZATQlQhU2UmJ8f0amyANji8pzrjZUrttCVECAln9DkpvXxZqYT+njgicaV9rC7Lnp8pP+jl7XNel6oxjEENoYMedv+GHCGII5q29f3wdnc\\\\\\\\\\\\\\\/cndWnMlWFy6fWWBQ4Lqs6SC3AET9lWWxR3OmNfS3ZfArrUe8Nwnpo2vdO2stj0HyTkYq1CRvA\\\\\\\\\\\\\\\/T4Dl6pQFiUgw8p20bXMXM\\\\\\\\\\\\\\\/gJU6DnmTOOj5E50UieO0MFsIprgPWCKHFVQz5TdgbjWuL7L\\\\\\\\\\\\\\\/0UeKAXv92wOY0R+yXBBTy0Y24qqQ\\\\\\\\\\\\\\\/Fhc6f9ya4ubDAl6UL0Xr\\\\\\\\\\\\\\\/8VQ0K3jMFnZQHHdM0lA21I3gCqku\\\\\\\\\\\\\\\/I=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00223NpsezD5k67co\\\\\\\\\\\\\\\/6feN8sBw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ea9495220dd6e934aa50bd967986f935e35f692954a2ddfcb4b7105a88c34488\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/4\\\/e001224corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/4\\\/e001224corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;12\\\/4\\\/e001224corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001224corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001224corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001224corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}