{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022+54E5IrAZCPuirFM3mdET0Aqt0oVdQO\\\\\\\\\\\\\\\/pl3swF38fPLxigm+tfv71QePJysglJ0KpFaMldLph10PU9jbgYkAVklQYe7IAdGRCO44CCoFh42ZniEbF3iFqeQ29ccPyQrH5M7istOhy8ahjyqKejwgl8rp95GGkj+w1Tui2GByB9Xiu1wlVWWyfNYfvG2ZzIeeN14C5nBH2SEqyRywONyaaH3yDWeHSr9ki3lzgeGK8FdFACqgOkjA4i\\\\\\\\\\\\\\\/CTE8f4\\\\\\\\\\\\\\\/A2mpXe42XEaoxoI4WKwW+xNb+vktwu7T18SFH4AsTKVcDgzN2UnFjWkeJ4q9W3BDcID3dENRUnYfoPbHOk\\\\\\\\\\\\\\\/S2D+dtK29TNmAdT2uagL7FN9\\\\\\\\\\\\\\\/Jjdp8cHlCUgPerZ2SpU95xEw5DMGkQwqdB0aQmP\\\\\\\\\\\\\\\/fUYDf7m8Yahh95pL5Mhgw8yi80likyjOyulPjsT79YbJ9GK\\\\\\\\\\\\\\\/yY4FYl\\\\\\\\\\\\\\\/eQVQ9NHFr7B2z6FvpsWoyAEtlw01D7pJz38aoCib5Aipbyd66PsCBsdZGNFJzyfcJ3V\\\\\\\\\\\\\\\/a1OxGrvResXVTV6UIyy4HZxfcFiRRsooth\\\\\\\\\\\\\\\/tS1TsqsYK\\\\\\\\\\\\\\\/RmqbtUiemC0YLQDV6kxyJl+ybfWctE3wN8WR\\\\\\\\\\\\\\\/1zUohgklpivbWR9cBBPip1s0dvUErct\\\\\\\\\\\\\\\/VbY5fZhRameXinzrXwCpjhvkCcFMAxHfUivbi1QIz1s7iFS4loWvYwM9awFEAVdwxQzIZpx6EyX\\\\\\\\\\\\\\\/MVTCj6ECeHjrx82VlcR0SPeu5OpWZz4XKhDlCXuh8dA5g1v9Ir2MUEu728A85YLc0L46gqoL\\\\\\\\\\\\\\\/04Pm+Tnk\\\\\\\\\\\\\\\/+yepJICAxv2Ix42P\\\\\\\\\\\\\\\/NV2ujpc505Z\\\\\\\\\\\\\\\/2YoCLhUnm1+VUe\\\\\\\\\\\\\\\/yoVI8SmtiJb5GlgjoOqbr3EhnFEyL1LqINgDEg79JvpMMHrKH6xoxBsQY7auHbUU12KneRvX3ibQqKOGA+tisXszgADhKWVR8gIG2Tl9G62yk1H8z9EfyTU5UflxZ\\\\\\\\\\\\\\\/FvrBdWehBj4DloKfKhEuJgNHZc1g\\\\\\\\\\\\\\\/oSfo9cUctv6z6mz1MDcsE1rKu2vtrt0wLs5wwYLCyby99jnj5\\\\\\\\\\\\\\\/MJsXLCaKH1ZLIKBygHe1a3sCzZC4GzLCoybsQIDbEc6GxDJ\\\\\\\\\\\\\\\/D326fAE6K2rrNGdxxiTvxK+WirwCndncURq0d1xeC5vCQ2janR8ZLJ+gkc5JO2eNhLEnchE0i0W77Ic40bxp\\\\\\\\\\\\\\\/uOLdwLGyg59rVHTgAYm+uWY15Nxl+v628qm1ZlBvQHIw5gQC+N2q7dC\\\\\\\\\\\\\\\/Mx5ULwFqh93MsK\\\\\\\\\\\\\\\/tD6LcfZ3PBWgHkcFpijkZxsmla1Yfs5Rn9ssoY1Q1zgGzHMScgIejQxh9UI3fjJ+IYpJZkY5sE2enmLezQjhQ7\\\\\\\\\\\\\\\/khr+0aalrVSL18uslW\\\\\\\\\\\\\\\/H\\\\\\\\\\\\\\\/JtTNFEqJadTSvu+s0+Ed5HVkkvCtQlbkZdQCWpeyP8aAssCY5X4ehJUtBjwuQoTowFO127TrUcP5BWtqc\\\\\\\\\\\\\\\/6abulmMBqTqoo44koANgGACo7tbeTmW+UsddpsCbgJV7uVSNe0fguLoEb42t8Qzd+eja2BFK2LiMt2Xb+VCPz9WMKZdZRhT4LrNi9Dvp6SF2U0lrRna4ldRP\\\\\\\\\\\\\\\/2TtmBEPh4EbURcmpYYOEV79rwRs8XA79p4doKefEOi4j8IEWjI\\\\\\\\\\\\\\\/Nvl3AHDDFCXLb0B6OO26LaMQ3ejV2MLaVlno1UbVsIapxH\\\\\\\\\\\\\\\/LHi2Q2FjWDl41989O8+3rypEETJBw00axu6hyYMHDd6Z03qsGpTW8gnaj+7xA1JY\\\\\\\\\\\\\\\/1h6JMDQly6MGCNn4NRibCFZln3Y0dtvexDWnWfeJv60wszeCrd4hz0ffxiEjCQEhUXkWJiEn888Ybh\\\\\\\\\\\\\\\/6VTt2DrhpYEVjJUxyEFsV2tE5cvTxCwbN6n5bYyCfL76cz5seWV4b0LW8OTNXRsPhETP15Ie3Uhxjln2SDvhTYugaJvKU6zFjEdEPyAChpTu+6Nk77jAr9WhP55WojvAOfR89maVMULQWy5k0snitzk1Vn0VIU91ElJk0orx2Y73nSGQG8Gl3eEU2RxtXKK\\\\\\\\\\\\\\\/yYn0P8+iGJSHvrpTu9cVyoC7xBckmkAE9YBA3z3ptZ1IT\\\\\\\\\\\\\\\/AsoB8b++eNzMLkaOaQl9TUKPIxC7K2OvvkC2h2+X4UzdS8yeVncqHw+FhQlJ8wNL88pQI286A0LjIL5s2yg5ynAbGZ9ct8naCDKs2+UisujcDSM2MaCuDThGn1tC\\\\\\\\\\\\\\\/4Zu9CsDFJL+G3tIrHpNJkmteuX9Wc0tcYlLEqItRkoJIlwOnFAvifiqcnQLywgsKOM041c8NIcGCMHGz37gbSEZnPYVg\\\\\\\\\\\\\\\/p19H8zQ\\\\\\\\\\\\\\\/RhM4yegCaJmujg4L2JQx8eMALXU2WQ5\\\\\\\\\\\\\\\/Kz8ZWOTqKnx3QrEb8PE\\\\\\\\\\\\\\\/aY\\\\\\\\\\\\\\\/xbJqGsiPBjBUWmWXlu3gR7a6Jv3x\\\\\\\\\\\\\\\/mIgXMDY1iII4IiVOPr52h3O4lIdfiBycLgkYwlx0MUaopw3IwlEKKHD\\\\\\\\\\\\\\\/lCCJKiX5jvxF5xAbjxTwAd\\\\\\\\\\\\\\\/kpukRB9Tj7AZJ8b2NZDvuYs3JVNBApjej\\\\\\\\\\\\\\\/uoxqAg+gdVhoOuEj08J26B2R0rCS9VHUcxgbjYhGn8QAY6xtqzVzlHVuIRQp0A7sgtE6rSBawhY\\\\\\\\\\\\\\\/G7PfjJPd0pVY8ZN\\\\\\\\\\\\\\\/atehUHFWiGFGL2Woq4flmVoq8QW60MvNj9yBwWeCuD5LcpA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022WoydKEi6HVV0BUTXWn+lQw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022834d81f383945a3e41c2d11f459f55568d7546383ad0ef266440329910c9368f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/12.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/12.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0116-2\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0116-2\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0116-2\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}