{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LVhZlSEeeh7jeNHu9Hafc+x61FGmAbnr4G81qZs3qVaBheAsHf\\\\\\\\\\\\\\\/CAJ5SJfO1NsUERR6\\\\\\\\\\\\\\\/ulUyPtN6\\\\\\\\\\\\\\\/Y3X6SqBFniFfkwsZbFQVDwmRKZ4CL6soYoEoCyGk5PRqA2sbujfRzOGI+hZnCb2uzP8VrNcJlNbPwtVQAYykpc5YZDYidFkZDh5roLzms0PLSZjn7+U8tgbhlSybCFtl4gfDkxzmPKPPwBpNKtmMS7KJ66h0QVceUPrJCCFrW92sK0nETOjPb5N0yJ5MLfKTqQ7rfSkXHNwMHp8POx9HwaV3V0J46RWh47UJABFkYsRmjJtggVncmePbK9EpSi1smWMP\\\\\\\\\\\\\\\/OejHyalVvInADPjlEw65iP8kmJJAVR1i1bEqPea7qbvoo0OsF0CZx+a3SU0xD6KJbJn9Ur6iEg2yFbpruZX86m82Gq\\\\\\\\\\\\\\\/UbWh10s\\\\\\\\\\\\\\\/wwfnU+LsglWquKycdLmSoiScz9NFPcNgYCpIUG8eWKN+whfdz0jg3uXce\\\\\\\\\\\\\\\/RKkdWhxdLzf6f5SGexFVsNUmMG30XuI563dvrlCfTBRDQ9BGEO4HEYjzjyJ0UkHDiVJESb49V9j+a+G9Hm\\\\\\\\\\\\\\\/44A3boErXFQFJq\\\\\\\\\\\\\\\/oTZDoGA3lPNIb+Md\\\\\\\\\\\\\\\/PaLY9hoD0LTj6s41DAcuN9OdnyOIATpSMZumYwTGUCs1QYOXL3e9YfjvxQTcvHjaj4G4tt6GeBNlohkJpiNNVepBhhjkhntW6QmXAJ6k3ShlXS6xgB8A8Asafg3HPTUavoae7sa9ph2eKmcT+TB5QaPpfh8E7a624ZrFJx6vdVne6RqidnVLbyXuaHesEGVV3503Rrcm9X2uv6lwXHoZRCsN\\\\\\\\\\\\\\\/wHdAslsj0g3PU9451\\\\\\\\\\\\\\\/UUA4ytK38KDWI5LnKV+NvjqjH43IKvcXM+J1\\\\\\\\\\\\\\\/cKD+XUdItJINrMkh2CPH+IjRZPzGH51JX5owzzsSPQK2vtMKDkxbcmPQ2tRFeP4Tbsrykl9PzENKr9jdg7Ew8punssxXQZoMcyVazjlPeXJWozBujs27CqzarJyvVdN0\\\\\\\\\\\\\\\/BWEkopjug94azvUNIm1iqinL8G724I78xeFfcCYJyIs+scBRo1\\\\\\\\\\\\\\\/AxNPur0VY9GKM8HbrSKS12hfqMzBj2hO5pfScYIMSgQQeu4z9bcByfS4vRllkewIktfD9Ut3b4+AaGZuLL8nwV1sfaS2EhvZhsaxH0gZ5BV29c1BlSAeMDESTDdE4KRYQKPq67zFHIGh5lnud9Z60+s0lKvibQXIT7sm9VKL4EKWzs0iL\\\\\\\\\\\\\\\/EYWzFTay1KuOM6c72Gur0aeDqwBFW4YsY5\\\\\\\\\\\\\\\/XT+6jVYHQa9GjugkxvSFnzSP+IB2RMRfZ4P3BJ+uKWg+HLfIjEI73oix+vXfewadCKXpdRZtnmHPN0vx7vlDveL5o1ONN7BcaVD2Ie4ja6+Laa6Ui79SQKwyQmBMzPVN\\\\\\\\\\\\\\\/BKI8OroXjJpbkhL2P86rE6hPVsKBy9kn7yGnIKZdeHuei9\\\\\\\\\\\\\\\/PaXkvUPu2PVPx8O2kDTDlfKqJ5dNHVo+q8WO92khHW8Ec+RIcl07y1TW9GKH9AvZkCXtR2dGsELBYcfvFMKQ6AmUCbuW5y96XrQqWOClbGZE\\\\\\\\\\\\\\\/UMw6bNwy46dxvnGXS1uNBL8jWftpbeYaP2DnTzLzPRmE\\\\\\\\\\\\\\\/1MY7x1IGVdntquHGLAFnn0F5I2vpt56dOHAi6lmVRcQ3uaoHE4UHFvJ0eumGy\\\\\\\\\\\\\\\/6yalcs3+\\\\\\\\\\\\\\\/uS22TIGtE7l3RY8r8BO5\\\\\\\\\\\\\\\/23pD8lg2Swljm+m00m7r0CjlTM73\\\\\\\\\\\\\\\/UsyHbjsea6HxVCzmmHlmrwn+GfgUHmwaVDOx4abclIZitl2s8UUp9usiMEuYouXEzE5sQvbKeJWnh5u8DRnm8+2gsQNfetKfbShhP\\\\\\\\\\\\\\\/xBRVTe4Qc26EMqjQNLkcKNif68sKmY9zIsjryB11oAnyvR9tjCxogqV7kI6A+fW9YHKPC\\\\\\\\\\\\\\\/mFi0dis7jxz4n4cAwjq\\\\\\\\\\\\\\\/xNdRrGJIW8soyrcgtR6I9EOwh\\\\\\\\\\\\\\\/AVxnQL7pSncYIvA0uJKX6heD8H9oys\\\\\\\\\\\\\\\/LKQs10w5Vc39RpkGflcYyrtfHTEVlfdocnE2z57Yd5NRaC6Q2Q0e2SndebRhFlpPuKdLC1buqLCPJ1tx10jUaFE\\\\\\\\\\\\\\\/VnNbbDesY\\\\\\\\\\\\\\\/uT5z2APrKWlQtJgEHX+PXhxn5f3nwcBu5SgOmI\\\\\\\\\\\\\\\/b\\\\\\\\\\\\\\\/72ATDA0boNkBbumLuDBg3+XeKgPnwpthpS8sgye7uHTMMVgCSmxUO5dI\\\\\\\\\\\\\\\/kOHHKglqgoWG82KLSCexrSahfJQjw3JYfnsXBs+eG4mgHYNMgadvhGrndL+QBxfvrL8E5c3uOl5IBsnlAGW+0pwDruJZ7KJYII242ghoTMbCpta3WXabvXmvpJydeoyiq7cfSIfSRC+uWOFj917YD6CjwsM4Q1E\\\\\\\\\\\\\\\/a8xC276Iea8FVG8tZMQ+N18L44LHSw83W339KxaIVQNKCGWU8LS8r\\\\\\\\\\\\\\\/sUe2CzV\\\\\\\\\\\\\\\/fzeWO004eI4NnR313A8pexLnP4pepHwzkY93LKT5\\\\\\\\\\\\\\\/CmgUio0UY37hUeB7c\\\\\\\\\\\\\\\/o\\\\\\\\\\\\\\\/cwhKPBJXuhLSu4+3FoklSfRhoCohNBlxekI4Ij5hJSefsYhEsk6eNLzYP\\\\\\\\\\\\\\\/oOBwndg8zJ71dLYE6AxaSIxOcPumUUTJzgQBmNm8MdWKVpcigSz\\\\\\\\\\\\\\\/pzRdrEdQNW8\\\\\\\\\\\\\\\/OpLUxgnRj\\\\\\\\\\\\\\\/fQbUrLA4ZNuHfwbj0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00220NYCuJnA2N8AfLbdwht3kA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022bc97b9b8594055787ce5ba72229f243731ebf453fa21bf36894432a215ce4aba\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/3\\\/e008694.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/3\\\/e008694.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008694\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008694\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008694\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}