{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221XgjrwHTMmLH24IyZtik2\\\\\\\\\\\\\\\/LM67azUGX+g7ucvoCyjBlHeHT57tBc\\\\\\\\\\\\\\\/t2se+F1Wku7jU5sGxpoe1PLsC8G+NlCJz2kHv0fTQ8YxAuqv\\\\\\\\\\\\\\\/DluTDXPBx8flWPPjmEMHljgDSZbJieIUhw9kRSxy\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/jqD0C4y7mjSXVO1x4WgtTgnIkYT+xq0xYTIlDnNXtoHKUrvqjdQgYg8XBO64ErXR7RM1nWhkZP74QWQKgF0TSB1H2oGdAeNYLgLeLBrBQiVDHQ3WojW2COBYQPBeixem1sgOjjlXu2nP3vdiPHUg5veq5yf5O+IhLs\\\\\\\\\\\\\\\/pO8+G6SismxxW2Omchy5IwJl5U4F19L2YGkIfImPCTLX4ifceQigTrOTsme3njoYtiLX3InN8FjdY84hF4HNrFh8Ea1zVPRCFKy8lD6SWzMAOnorFK7uXBbSwRjshFjiPXHkZ6Yv912KEMsqXIBb0N4kkWu64UZHw6pwzDh1BnMtuSF7IT+Mxxs0lEoCxLc0wFE\\\\\\\\\\\\\\\/Yf0b28u7b2LkJxw+NR90UHtD1KvK\\\\\\\\\\\\\\\/hvIaq03Z91bQlo6DduDOuxN9Hk1yz67BdySIwxfCuQ\\\\\\\\\\\\\\\/6uG+emtLTbFfxeEZQKbE5M1ZyESzXCh1MlSvrNKadhv7HyHLpJtd9FwbmQlc41dQOgh5PMM+Oy9Xa3fo894KR24XtVKrUe7Mwvc87abBqqvPkswJIkhveIJzSWbi1Ur21dA3YNAUQx+zGXMM32WNmd9HFDh9WR4sGgc9G0b4Kw8CuztAWwT\\\\\\\\\\\\\\\/kr70rh3orzm+NFqXT5IrQKkkG5jANh5b1NAhILApAh5AdQhPR9wPb5BWQMOWN545sojKKosrXLPGNy5OzYrIrSLJgzAugVo2nvoMpDKITeUSz61zFuobNBveeffahXeRKvkQXZjffMpbb3O1g0gHvGYdO9mJuSFZa1z7kEBsj7pM7E3H0TYYAVAP\\\\\\\\\\\\\\\/AnrTubHbKZ89pWQr5+\\\\\\\\\\\\\\\/brsuTrYjRxzFUB05c9JylAYsd2yvHCVJ6Js2xsPPsBxvTZRewB4vpDSw838VCI89epRYCAGKMJ2p51Qt62Z3+aucAm1zCeQwkqm0LMznr1UbR9q0IAWGUqUp09huY2wgulSCE90ExZA1QzqrOP0F8KRzaShA9delxuwBYRsE2BIgAHp+sP669i9V\\\\\\\\\\\\\\\/VCEwtZyUBorj5tvxSCYfua73SqCRgME3mBYs+xVYdb1BU+kcAqoNN+dS4A6Tw2wL3bRUI3e8CoTCKcu6o9DzIxAg3CTzHoPY19RPSgImnZ2hoOLhZgZSMiFUjd66AQNEh7yr6xgWaU8GPz8EWZL9K9egc025VB\\\\\\\\\\\\\\\/0+kSjjcV29FuhnaIKxMlwL+sDu4xKq8uVuVPN1CeV3jwzROeVWyUdNyiJj5dz+n1GdzY36QvNV9b0dFcyplKP4wBWyIumI9chHPkrIETaerjBX8ko3aM097l+fxN5vCT43rpv52sTMxxUdqbxV322K\\\\\\\\\\\\\\\/FzIwIaEEILrR4hLf4kK\\\\\\\\\\\\\\\/qIZTPBnjk5T9ZK1cx8E4gWBMYclm0sXRbUR9iFKjLme5e+8ZpOuT5vUcj+RpxeNLaY7EwI+91IBRt3zhEoPt7Buc4J3Stc54e7RlEVMFylCnyzaBWEJMsh5+djjpy3a1bVhFI0onWjRvaYTk0bvyvMr93KsQFG5SyLocmb9VzlIApThmVInz7ONXbKG3apqC6ENDSP1HAbXjcFRAuoO0Xuz0xGFFEB84Llb3EO0Ji40MMdcgkzdYe7yjQSTTDXI73rE4JhMchh8dH9ooqOPtGeExIVRVJFM+WJBF1\\\\\\\\\\\\\\\/WWrFrKywsxbHkPd0\\\\\\\\\\\\\\\/r\\\\\\\\\\\\\\\/Pj9UtVLQ1+atT29tvY7ZW5AncA8QraJJ7PC2CfNNEIr7y5q8xCBj5EFeGTAIlsUhRGYlqJhRMDf8LRVQcu2Y32w2ooHvF6cSre3eJOTy927mO7IbUJJtMez\\\\\\\\\\\\\\\/xCB9xp0MYux2QlChj+Ftv1TNpm39nrUgf5aQE8AwYq6PcxtsB+werEu7ACceyQFpH5EHcetLz9jedBGTrQhg2VB20r2KJMLVOWYXEXgf6mS51wK+pkVhkh3QHwNuOyY9anQNzntNxxClT2N5JvCI+G1Rru9t55lgVdfjHC+7njHqk9wH6LN6kfJGOfcf6lPoGjy\\\\\\\\\\\\\\\/BQeOh+uZU1tg3x7kyLQ9z2\\\\\\\\\\\\\\\/imqPGO8ccwIj97pLW+SCMb9GT6cv4Xji\\\\\\\\\\\\\\\/VeDFhn20G8sy+4S7In6AXA5cS6\\\\\\\\\\\\\\\/Xbhpq6tqqEzo\\\\\\\\\\\\\\\/f3sAW0oTnkCNQsVw3yYrnTEfDkaZTRNtS5kUCEmClHrqyRaxNb2rtPKOFD7f1VBtpcHhMvxOtD6f+LpG9FDG29Vlkdqb5NsuCOIy+3Kf0XjekR\\\\\\\\\\\\\\\/07bFgB93b+D2alnuO7foHacmsD17RAoxSbJAPQxDlCBO9e0QSpSVNkJIvLxE6XXur5J73vI+HFcJHnAKVJGGuwTom\\\\\\\\\\\\\\\/tpOOGiMJutY2f+ueKg6oi43Q3f4B9NBmVaIHQXjb9vJNwhfIU2Ticm\\\\\\\\\\\\\\\/Nu3QCLGyr2blSostBFbXHhYwzenP6uWCCOMMv4pTO5jqw4kmsjVIw1OgEm\\\\\\\\\\\\\\\/NlV7NcZyG5q3wjxS8DpgW1tpuLXRy9vvyzQxmAx9aeniac\\\\\\\\\\\\\\\/z0O8d7ByWP5CTemKEH6qR7bWdcmuoRxqeX6Voh8H2k=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00228rffFgZfiK\\\\\\\\\\\\\\\/h81eqCGaHDg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220f9786d77744e642a53c8e448edf71ebe40e35954620392b59c9577a80545686\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/45.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/45.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0149-6\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0149-6\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0149-6\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}