{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022R9xn4xCjpBtDVUmBqk+n5LX4EgMt+rjqdl0cSPKxA+njAPtYCTDCvBLAhsc\\\\\\\\\\\\\\\/jv+xg+Krb6gStH9f\\\\\\\\\\\\\\\/bRJ7FmUZGr5lfQKQniBWhR32ilbqZHmCfknRNimSP8UUO3DFdg7B0ec7Dj5XMGcFSaZQAatJW6YkFxs5lT4EQW0iD4dPHpAOUHyDn540sLjnzRoTP8x373OCTU4jKmjSEO8u15Rw+XD50jJjP0fdFhTYeK83NglCicya5DRGkKh3C\\\\\\\\\\\\\\\/I1RBgsV3TECiW3BsCWaJPjH\\\\\\\\\\\\\\\/2wsx1B0wyxak0qxo2phJ3SsDGdozgwJY3lZthEntP0yvH8c\\\\\\\\\\\\\\\/v6ZdNR9rh4+Mey2u3\\\\\\\\\\\\\\\/LjxIP6rUII5QMngK0IwUc3iOtXHhhmq5Xdt10CgCtBhpXF98a7tv83FvfVLhKMiW6aPAPCuTmC+ZmhpaoNrC5iGxChdHWFjP8CeEw+9NECmEWzb8nKqgxulfb8aV0fDwzYNx2yeqlorFR2QXFOi00fHUWiaOwywkt\\\\\\\\\\\\\\\/msdRJ9P15AhwxgL71dHfr7oXTzSeHt9Hnxka3ue32FTabChe6qv\\\\\\\\\\\\\\\/1jA+\\\\\\\\\\\\\\\/c2r825YNRaU1OZb4jUHcwdAaAnZLXvGCo\\\\\\\\\\\\\\\/Eiv+Wa87qmdLv24r9Z7JJe8E+YcYigtIkIkMuhAVE8smnNPso5heAbWe+UvQy+O1Wn\\\\\\\\\\\\\\\/8IkCJS6LIzZLg6c2h36VdSXdJCg\\\\\\\\\\\\\\\/PTrsdZ5l3k5QCc7qglX4+is8sjfGaIt3O6L+1ACuY\\\\\\\\\\\\\\\/8k\\\\\\\\\\\\\\\/uNrw478cItenCWBdnGY1MigXGPqgd4VWEcnE3Z0uwpHLQFMcN7nnHs1X6yGguZGChAeo86uXuGxpcSIqg0dY\\\\\\\\\\\\\\\/6e2jwXImaz+1WUJyVQJ1shhEDZ97Iyp6Insz0wv3s2x9sOx2gaEtG5GR3UhqXUBU+QAapz2+GxxhQEhyb+mse6pfP41a3sTqmbrLicDRSylybp7CYOy9P3KtjBdway7BmXqCPgIWKTN1aMhcD0IloaV5rIIVo3dW\\\\\\\\\\\\\\\/ny51vpPaUBFYvLU1TXijWZgQamO6vLoMlASzPl8kPUtWZy\\\\\\\\\\\\\\\/D3Y8dILCprgPhs9pmXsO77WMzoosQ3nMqXlkpNJ3Jfkxwwrjmm3QZLzi4CP3yNmIsmunQsYrYBs1G27YYGgMRgs42cl\\\\\\\\\\\\\\\/8x1vNJg3Pc3UI1iouS4QbqkwPnQplpuImUCRuIEhUUZleNMeaxS\\\\\\\\\\\\\\\/hX2u\\\\\\\\\\\\\\\/KB4n5GNn3wEa14\\\\\\\\\\\\\\\/cZc22kLd2JzXrEf6Mgq2a\\\\\\\\\\\\\\\/19vfFfF8kjuwvNF1hE6ZYDTMATUfs1Stky+TnzTLWf70I2K9tCqLC0Mnqfng1Eo4fRyuTh7VE7RVlkGgxx3ZCtrBltLSF7Id7l4xNEF6icsB5GPdkuecJgRVzuIlPQbrOd2dV3I\\\\\\\\\\\\\\\/Ia+ne3DXJAALJdU4oP2Vkf86IXnlr8wsMzRdLxJsyLta8QSAsCoLKh6yDr7cLBlg0OKPYOrxgVNme88ZjZgrPmRkLk3oFixumU+gW\\\\\\\\\\\\\\\/E+Pm9dPbQ+4\\\\\\\\\\\\\\\/V4uenEnF1uB3usC2uY9dnLcIGc4YD7BzkmZnT1tbys8InWBjmKqPCioBtx90twD6RYp7Drk9cisMUiUT2DFkVqh+zsVmSzHk0uPER09HxT7jhD6RrjLWBzGqBN8vikMmQ6Oxs6UsyhqJyC9KNaaQZd0a8agsaKzDV2ZqBzwiWtaBfmEaxzBUzXCty4pTtglhPgauS9\\\\\\\\\\\\\\\/NfY94kd+5iRz\\\\\\\\\\\\\\\/4HzkplRs7RY4LPi5nWs4ftZC3bomXQNMqqyUvXG9mus4M5u3NrFEf2VQRmKtOHBsmvCF5HGNlLLTgWaqS4I60wdbvowoETX41FuFm4MKuR\\\\\\\\\\\\\\\/0IVrNaIQIBO43rrdwtvzY5KlX\\\\\\\\\\\\\\\/NMXqemDVcGuq+a53e07CZMRTkk2qe0659QIhf1JVa4aisu2A4t9ne93WBeeYfOlfqP\\\\\\\\\\\\\\\/TAsYXMmCzD4SjXlcCJzJFsWnrzF4DESfc25gsEz2mKTKVMZY43q46AyFdDL0qbdIlfRiq7WVErBveJqQaJzjflZJxlGrvr\\\\\\\\\\\\\\\/KekIwUnvb5gvtkv+AF0blSCXvaKPb1\\\\\\\\\\\\\\\/knIx2k7GIdLY+bN5AD7bw2pN3uWg4yZY4ECXdzZ8TTzwf3Gfz33cWglbOA5LvTaddZhD58JXa+XSemQbBfCzldxEXKq\\\\\\\\\\\\\\\/aYh6rvslw8aDB+YZ\\\\\\\\\\\\\\\/dwFJXV5iMRkK8VroUMWdVX9qwIBC51TNqMqA2q2zkFTT4ypzPz\\\\\\\\\\\\\\\/9uTMoROtJksZFqLuOITMeWesAj+91zkY4jk4HSaPib8N9g3QrkpmGUt0UvosjsNJOk+lGcobwEeGBBPxxmiDh87Ng4ZmFOB4ltqjbbZpSrkNcyLjz\\\\\\\\\\\\\\\/r7g6VbFs0la5BdkgTEddjYmmcLlVOLHgIQar2Nni48sz2Ms3CU+8QvnwsaEcSWKqfn99RKZS4hm2EhikAjWgE1SC0SqxyZjpYeA1n\\\\\\\\\\\\\\\/ihoPpqACPfgFhh5JpysYzWXKoE2GWVC2BHr0WUe5BOBrtPnpI2LnkciDQNXsc96V\\\\\\\\\\\\\\\/qFtCL8Fu3LHpneSKatNzxBeE+PF1IMPsqfKvs9Yrjo5EKc8d+\\\\\\\\\\\\\\\/z0U+Z13EieKg0T4bbhZH8bZufYyCfBXbdBQ7T8\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/WI+jkQjJeHTxy7nU1vsDBzOW2huy5h15uh\\\\\\\\\\\\\\\/yjTVBelyxb+WSz5l19VizMmh4EHzLOTrEUw4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022h4RU1UC4Sn8wjH9aGYeFeA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b4c2184e3395775753d024fb67a3966dd551ff5c88396f786085a2ccf1b83d70\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/3\\\/e008482.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/3\\\/e008482.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008482\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008482\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008482\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}