{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022uLbWddhVJo0kW6GjUFt5WMFnUGMTjdLWKBDPGOl7W0AEk3fJyIB6gEvs3W6poiu3pwdoNgHDP9wRjSSu65UZcsW2zGch2exnelF2RZvLz48ZfVyJTu7eIHNnE168o64Y8TNZeBASy+t9FMGy1DjJSnm2t\\\\\\\\\\\\\\\/V\\\\\\\\\\\\\\\/A4g08dK6NwWWFiTwxGgflelwFpuzFcXTTuBn\\\\\\\\\\\\\\\/YudmxsS3SZHfaI6FpliKpoGi\\\\\\\\\\\\\\\/nMzUB44N4JE\\\\\\\\\\\\\\\/hv1AQSWgXO9y\\\\\\\\\\\\\\\/H5Vc1RTVS3Ah+SbOJDCJHSPuFhRlnoU1tIWgU09EMnLc6XgUrfvWCIuy\\\\\\\\\\\\\\\/eu4b7jzAxueGCSOhgEURrTkVgq77GfzLigLWAgQKbw+h8U9vKX8+7B3RscjTnJNdN5k2muYkvT5\\\\\\\\\\\\\\\/o8LiBdfa8Os61dQUZB9LzN1V\\\\\\\\\\\\\\\/y+DyF\\\\\\\\\\\\\\\/bVSSN7q55uZVP9nzLkeVJLRTkELMmiAgEUUuAmFlwnNM9w45xH4zoTzNG2tgGVRlHQa6+682BXpo4YczncBkpXcymHZci51hRBR90NPbbFUlvOIDL6iIVD7\\\\\\\\\\\\\\\/pgCelaiZ3Fi1ohpvan2rnnHuYwZYTG2YTsL2Q17Jg2vqdgywcUR6PQWaSkP1T3M7Mg9uoaDhzd3n7xrfQNPSjHDMsSim\\\\\\\\\\\\\\\/xazR1Zm7d2XNp4CNIbwqd3oNesavnbB2K9oJHyuK\\\\\\\\\\\\\\\/TWx8LlNCu3Hy\\\\\\\\\\\\\\\/1lW1xmCiRikP6eeS\\\\\\\\\\\\\\\/tYDLZrbdyYEhpGV8B8j8F57kFMSJYM5PpG3ABpdfYrPGeZVmE\\\\\\\\\\\\\\\/GT1O4chV9n08+ANtanE\\\\\\\\\\\\\\\/x3\\\\\\\\\\\\\\\/D3gG7hQzCunT+rBxlje1rxWjhzG0LUVoSaz99TR\\\\\\\\\\\\\\\/h1ClO4zHpKYfXiNhoHrd4Inn7s\\\\\\\\\\\\\\\/uIfGT9WHylmkTg1Liw3ce9MLvnRw4huNnbaZdXlxoAPnXpcV3uXmdnlbg7EyVo7+XTvU0IWD87AIYac5LSjEMevub0hTAQ4oLkx+loyUnvWiG9AQTT1TVHmex1\\\\\\\\\\\\\\\/MhseCkd760Y902ru2RPQ7hlbfCZ423xW71I6wngVMV5WmM3QQ9+ml0+r5WFtUT\\\\\\\\\\\\\\\/bsxbE22HP17JrYeMBN5HZ+UbhB43ao\\\\\\\\\\\\\\\/chuzj3se7UXdduBjicIt4Pi2ZzK\\\\\\\\\\\\\\\/Ql\\\\\\\\\\\\\\\/SDNTSH78Znm6JtEdkvf6aebDrT9+rlLSXY6GP7zIDfWvuaTY4gS7qYJr\\\\\\\\\\\\\\\/IqBXYSOk9iXGnYYWNW5prgVmdLanog0pa7cJq1sxcRKLKfKKSq8PGqszRVolxFxZlJ4nDkOuGc3d4vgPklagTh5L6g88teVDiBxl2LEN+Y2LZu8vMFMYgX10QLjeXioR76WkqPoHu++t76RcFcu7WcVNI1Kz8ZxQIPEBROtsT2kMVBzd\\\\\\\\\\\\\\\/LLKH3ObmVo6p8M2W4\\\\\\\\\\\\\\\/+kPlGvQHL8EnUeaFaPFBUEJr6kMAnk7mdjuY3tPElrLaPN7UmiGS\\\\\\\\\\\\\\\/3F2yjs9Y97ApFKhYWMGghFXDiQkVNi7d\\\\\\\\\\\\\\\/EOU6prEiEp3uHeBJ62UGWCBzuNDKmy8ohbeLOW+RlVze04\\\\\\\\\\\\\\\/NUiM84QDESmDcHRv9Qu7FRWO5w9TlMTp2NiFJ4\\\\\\\\\\\\\\\/AIcagG+iAmgrAO1ZKW3BN6UXC5nzXQG92UAUinDvxCeXuSjKRRQWcIcqkY5TsQNT85zVrrqIKSEbJ+DrvkQpIolp2L6yVCfSweyHiiM30bt59wzUidc4kgSxzkdxZJ6WaFLWGphit1g1WzGoxKJpzgellSpSeMvXcZE\\\\\\\\\\\\\\\/JX1u+aym28Tm1UQccTmsj20vR+dHMaULqowEFacC79WPQGp5nOH9xYmwN\\\\\\\\\\\\\\\/OV1WHLw7w8GZKCxi7IDfz4Ywk1\\\\\\\\\\\\\\\/YSVshyOTExlmofX7SZf4t3saGlbxr3CSnAkl1Kb23ZA9eBEKzyKmCaFkfu2veflviAa6ITGtAhQ1uwP5r0OP96YjqXR3JCz1T2a65ayLyKbpWtCe9LitRc8UcXEbYy2mn0k5RY+o6Sq6+O5Pcy\\\\\\\\\\\\\\\/D85MPlxVgdBWSNI3hLz1Gor4KPnM3TrlRhaMijVeQVdSKtjKfc+mhuBrOfGafx1gzkhXNncMkRLSaHAj8JOGxGPT9pk0bQeZqAC8tm23bMxLpgcSbzckvTnAe9KvKc+ikWH0MN2OpskjtRuCnHsEXG1k6zPVJzU8bJq+iHi26RqTkNQ89KTQ9Q177bcRcWwTGa4HbYZ2YeFlecQIKAixWIK\\\\\\\\\\\\\\\/xoZ1xz5b+9F91lVmJYf7nQ+wwzwVqhe3MgSiI0fSNCaK2FFwyIRtj4KXzm\\\\\\\\\\\\\\\/SN6EzFRj5z1C6xWRrEQpO\\\\\\\\\\\\\\\/Ezg1LjtN7Br3jGcK7WQtW1foy\\\\\\\\\\\\\\\/pcc25KTFxxt+hSo9d0hvXtKSoA2MWrGUm4vXo1wcDQWOWDe1NMPczLObTONSv0PuOouCaYZ6ZJ0mDhZi2IZjcOiNfTHXzUlNfxeyQghg8EvRu+zZVa4e6WEycFEk9Fak8vxewkRDhs1u9lhKkbtYa8au0neOURMLazU8HzKicJoF+FqbXUCu7FhAfendlpLinIojxobGZcAP26pwMglilDQWMc9ydFnknXhV1XtVK5UFjUPW5nahLyhz4Y+byWcpdbI6LpCk4d182Ts2TKEXn+OSttS9t0Q8+bdXmCed98IUpVfLJZaRq2Ce1kZW8pbVPCh5BlIJgovwK\\\\\\\\\\\\\\\/PyERo5ighyfZ52F72208RG5ryp7Ixp2gQCopSvJfo0Z5+y8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00229LOpHFN5ouGSIWeEFW\\\\\\\\\\\\\\\/a0A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022a3b3dc0dfdb227ed95e1f6ec74a990bfe9aa3fda50a6ba89276258b215fe8782\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/3\\\/e008744.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/3\\\/e008744.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008744\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008744\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008744\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}