{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022S0VoLEcGss20Sqh8V8ghkwz7B9ZnFHQX7m7URmJI7xjmxYi\\\\\\\\\\\\\\\/zHCwtLD3cc9StUeEpVWJaTmAn2pHsgmLMPd7xwViOgKtyzVVLh+hhagVNQrKASjw\\\\\\\\\\\\\\\/slUt+xp77GvqxBA\\\\\\\\\\\\\\\/L1juBWXdRJpLi7himmdgrmvLgnIlSh5t8GYf76bYy\\\\\\\\\\\\\\\/t+yHXCMv6tAQBKC0SAjD9tMzySD5S5VlAuDSboD3utN8E8FKY4Fdhuz0aUyMsHvd1SXtB\\\\\\\\\\\\\\\/AIt91\\\\\\\\\\\\\\\/NQD2eCzd7F0k0M3R7kgWmscVZNx1qPUSl+eCj7tSoNEu9763GuBYowt4f1oYyfUyVjPED9um5HsNz+FG4ut5ZOxmR5TOzDy7lMeoYaTnU4r9qCdQI2w2oQKSUkPr+Ynm5RM5OlbJ5jMu74PIYEC8mn0mj61Z1VrCDAw3T1Meq\\\\\\\\\\\\\\\/sbYcsytLCAFHDRlcS2+Ftp5TxadBZM834QKo498j3u+t94dBiBYdwvkwVTVMC8HmbTYIOlXfCHLMavXwefGXDbYSZC+cdbzyvjZaw0QDnCE9Y+xLpp9OUeIkkae8s\\\\\\\\\\\\\\\/8gdSB\\\\\\\\\\\\\\\/3kPCuqHm9Nm9+mMoWUZYka0AOZestVdbsvPfYdYNrpg3xyzltqsywqvz\\\\\\\\\\\\\\\/+wfE4VQLBxG7bHOVE6a63yFEXGM4ZHeCbd6JmquKjVaGpGpvLv2S1Jmz+XgWt7TsWldZ5e2sJhIvWE3CULtFLKB380MLE879zEo3IXgjg1UI1C6Fms4xPfEIb579RRAwuTqkJEt4r7HeXJovM3tTO4xSu4Jy7fZ63hDM1AbJrPJlbm26nlym2rwB9whey4touUxnBN7AmRp2WhYV+XQgm6a684U9e2btW6mvnp3AVEvvi9uYT8isfoVFDp01++9f9v86uDdDhOcxff00A5grdD3b\\\\\\\\\\\\\\\/X\\\\\\\\\\\\\\\/YhNZrSfsk2TenhnmswPn6nEFKu6cirbvYnJw2DfW1QIw\\\\\\\\\\\\\\\/yuKrz668z\\\\\\\\\\\\\\\/l3NE0QfKD+nhcDZzwmwIIO2DNfx6MUPhm9vuUiF0XPzCvxzThNDSKML9ko8nbPOwDHb86HuTP6W9QPQr9KacIGIuc0RjheVRRiXwQcWuXxQztRM1jHFmDX1ocORiocx7laKDSgfHXw8Y29Ugy07zplHHvYc3C1bZOKh6XvMX2iTpuDI6Ej9oPOlbKXNmyHaIqxsNyubdM2BnWTAQQqb2LeTvNX+N2QasB0msQieWFiS0FhD+pb2VwlG+9W48Q8Xe9HKEbBENTxW6GavU0tX2p0iAyds81\\\\\\\\\\\\\\\/hPuKAf\\\\\\\\\\\\\\\/ZN3jdeft01U62PFIHOzLSAz6KSolwF+AR3cJJxUILwCJIoqs0T2Gib5rrYtnzO37fe7jpGj6jQXDDOUF8pml4nQvPCyaiUeX7z+hz3joitRwym\\\\\\\\\\\\\\\/fDuZAT01H9kXb1+d9wQfHDF7fm14MjGOru4WghMzewS54oD0MhXr9qXn6h1wz3HX9\\\\\\\\\\\\\\\/X4LFcen+IEdGPLAmcd2V0BuWBRsRHn0egxfbJXxBQIRSclgFmS5UHnbApfN50MpSkf\\\\\\\\\\\\\\\/zipxXSKPBLGfxnQM0OguGg2+2Ewz\\\\\\\\\\\\\\\/pNfhzyD6CMWtkFZO\\\\\\\\\\\\\\\/ez+yXeNPRe4LkBHRjyzv3YItRMLTn8wEba69\\\\\\\\\\\\\\\/csTH+hzZQZGEshB5Q5BfBmQ46kzjjlRmFGI5a8IdCJqhP0Nm3XaOF5teLI7MvOGXJ1Vl8YVbiSh9+51UBC+ogn\\\\\\\\\\\\\\\/v8FBSO33PPCKaKaWO2QNEbzeIvRu4SbyHVFUXC4eiXa69I54JWAF0rwkJvI4ctPc5X+nuS6E0hpxnJtieda9yJjkCFwJg2FpbKnnKu7BWHWfzYMBiislXh7EktQ7PG0kXJ6MQ71QF3eJp\\\\\\\\\\\\\\\/cifyHzMVCMxm97Kt4hfSFeBD0OBTIaksnqFU7StP+rtEZfZfXcYDKge4cKOllER5FLTIZ6PNp+Epb04dQVa9275Jrok0ERVx9rT1JrW0mnfR0SNGlBwg11V\\\\\\\\\\\\\\\/6CmVaLckTJvuMZEY0KUdB+z6xcvn0wbGeNi3SoUwea7RYmU+01uOuIi6d\\\\\\\\\\\\\\\/iIx7mn3IYx+Jpx09XLq3+qPIxIwebVGWZyXlv3iMgXuKCQhX0LXLaTpgNGJ9SpsOm6f5CF\\\\\\\\\\\\\\\/pL5Iqxwfa4vtcsg\\\\\\\\\\\\\\\/ntgCX2ShNAc\\\\\\\\\\\\\\\/CQOf1ZxOaCzUvgC1+2IMe2ONPyoZc5\\\\\\\\\\\\\\\/5UyM2qlw4PmDRK0miHcNYxsZkWHsHwaVXCZKzgCW2MwZaeSRVoWT1lVy\\\\\\\\\\\\\\\/txNUUGKo5Wyaq4liYNlP0iW20HCofrfeEp7V7HiOvw0F2HClDu5gQ8ojHnmQ+Vc\\\\\\\\\\\\\\\/f+NkfVPUGdXuc2UUIt1o5LB403CALCVj\\\\\\\\\\\\\\\/fQeFCUn6Bh7dMnFAslKiZaP7fDPMK7CLjNMl\\\\\\\\\\\\\\\/tBq0H0ubiikKDL2qnWsegHI60FYL10QSRa00DSp7Q8pQCwlqKOnMj6NAsE7NS\\\\\\\\\\\\\\\/oUQeF2+h9Zb1rFUKlckX994vzHrKyCb0g8wRuUnk1D5jdw\\\\\\\\\\\\\\\/svMFaS+PIQM3JZmKA\\\\\\\\\\\\\\\/5I5F9wIX2XnZb7b2AiS3qyAirzSimU8HJKDl\\\\\\\\\\\\\\\/RVXb4hdoxtUToWASnlVJ5zVLD8qSHbe3+nbdHt6hcrRrmkenV8+Om82RIWat+FgdBwruq\\\\\\\\\\\\\\\/LB846GePWFAiUOakMTJAP5ryk6aPE\\\\\\\\\\\\\\\/Z7El1lZCabqYafDkw+4xSBVq\\\\\\\\\\\\\\\/fBmwD6IIT83EbcNQHWLd\\\\\\\\\\\\\\\/k=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00224VJnwEEom92LRBhpz1aXPg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002263f5cfe38a0855c285329dbd33d3cd1235f6fe368a0dd220852dac038f0a7e0a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/62.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/62.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0168-3\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0168-3\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0168-3\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}