{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Jn\\\\\\\\\\\\\\\/b66lZwbbLotxni3u17WhnMi\\\\\\\\\\\\\\\/MsbN2mkGvk513nBEp\\\\\\\\\\\\\\\/KN0B+C4xd2PSUzhU6rVq+beeOyiO30uNrC9SCOekARXSTAZsD+f++Qtow3GM7lGUbetM04KTcURmw3ZTgE51gR20k3HE78BXqE91hwWmajuvyPFtGYXACLuwACiUn1s5+f3ccSTtQqHuPmCVGVseUCpge6OsVkhEOoQ8ict3eTjO9JFZfnszxWgJ6DQV7FNMU0VJ5YbEk7\\\\\\\\\\\\\\\/tueYXE+Z6DJ+ETeNO283rIcf5kYVQxsThetqcrRQP5AMb0KL411J7h0DEKVP4qPLdFJ6S1G30fB0ys+GaTo6VeHbXCeyXPK+MgFq5dG+PeJ5XW3UUYp0w4GO0mjhtP22j8aqgqLeQLtdM6heM0hcyy4g1EBsUKF1zm3KQsrB9zCuR\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/hKNAhUNxdPGrRM5s0R2NjLfMum1zm8bP6KVKR9pBdOc3sNEIN2RN8SrwpLW+7kJNwnI77GPSKduGcvPOULmxOB87dl\\\\\\\\\\\\\\\/4ne8st53SBvMjHgkJHYAcgcOeFzU31sQLcRiHIbMe8\\\\\\\\\\\\\\\/jAfuRlu\\\\\\\\\\\\\\\/b+rRivpjpspgyTclDgydDUNxo\\\\\\\\\\\\\\\/MMofAYXSyfgEAhJc7Nr82asa9KlH2HXNj+TT6z69VSea8Hr+szQs70dnVQIVAdmLLmMmrbP0gepdnsJkqZpX+mR8LWVsss6tUOXIdLwllT5tJsEZWMbXApB1qHiSuDZZsvn83NMxI+3iJAM9Kl\\\\\\\\\\\\\\\/KYJnY6yCy84ftRMHkbAgFgFztSMM1YUUPd80cP3sQPmx8cYgZTQy99XcOESy1QJHbombqigQUbTcSzj7KyC1DsOxrU9uJgd0\\\\\\\\\\\\\\\/7zDGnoVeTGcCVpe2TFg+lOtxfxSGYqn9J12faZRcQ0MExvVUDzxL4B28DlkPDW5UR5DGj3ftS52uORFv5L\\\\\\\\\\\\\\\/eg81Dc4RdlE3BvDP2nm4LgSmKyUub0LQANWzt0ZRlq+Xem4Qkm+3nWHctm53KI3MPVcgikTTZvGqqrdSEREoa8fyfyYDMfNSghrNCx\\\\\\\\\\\\\\\/Bes9tnj0vkIFym7Hb\\\\\\\\\\\\\\\/37Sb5BPKjWGnzSdNRk6zky2qQEq1ERratqxhPRt+3jVnInuF0qP2\\\\\\\\\\\\\\\/kGmSofvqqs7JcOUYwt5RToUmzf0OgwjUidi9vj5QGf8uvrDjyqkeuJpgbbRcUV2XZi+sQMjSy04fKJbyUBNJeHasCy\\\\\\\\\\\\\\\/z3srANiMZg5Fl9NlV0qu+\\\\\\\\\\\\\\\/0t0xzL0onLEGMB1esgMgEbk3bjXysGMZWuwEbheVZZYzAV5ashY57\\\\\\\\\\\\\\\/NT3j9unFwgPYArc3rvMv9oQ09L0swkihr2\\\\\\\\\\\\\\\/tsro0P2Y9n7i1Xc+RDcOJIgbNwV2KQn08aMdUORMFqpVjswJvQ1ksTlV6UWxbB1EAqfd5sOu61PvlHDFV1qLLMPJLERs6ek\\\\\\\\\\\\\\\/UUO\\\\\\\\\\\\\\\/srkW5zzMsQGZBKO7JngZ2qJD04ujPEZWjMIEJATzIeb298HNswh\\\\\\\\\\\\\\\/rKeKTCl7LQwIyB3xOZ2FvDfFSHq+byQ5\\\\\\\\\\\\\\\/5nOmRU8uf7hydYYlKZRf1aS7dqCcQNF+HgBEwjGOWGI1e\\\\\\\\\\\\\\\/lb2L6K2QckRUaeWbp5O5zNaBDZiYJ3Q4LO8FM0lRKx8HuYrGCVqp\\\\\\\\\\\\\\\/++y5NenXrKSnclUceLLEWpK5qm1vYIBBaMG5l\\\\\\\\\\\\\\\/XqPHvTgbyvIMCRQPJmhuqMH++3JhdnQwOMf4iZckwEFvG7LqWmWypT6JoLW2gNLU1ZMLtdaOlJesG8K3Kx4kBrdNvWsjGXmQE\\\\\\\\\\\\\\\/uTOwZxRaV2MeZR9odyp8RV3yPjGkfTAzR4n7f+HBWA+lrx+beajeOxmmCjE+8DhjVh8TqlBFPr0uOF431T8n+6n7ifBnG0STcZnrFoXnJ1Da7kfIaMI7CcF\\\\\\\\\\\\\\\/JpVP08tg8yZyTxI5JWcel7Tl2o\\\\\\\\\\\\\\\/7tX6ZCIqZQw0YfNxxzB8kYFmPneidiH3MVYN\\\\\\\\\\\\\\\/NOTxb439k1XEUwdXFEiKjGTO5xvVzlvAZeAnjgZqxKiJDRcodlTaxlR6cfrWdIyIFjJ1kredk4XLh9Kue\\\\\\\\\\\\\\\/gTj5Nh5ia9QPESJ5N3qYsV6m1YtPgJRNdry2oY8tARpZA21YUqOK4DfAFxJStF3ugddwABv6tTXndNnW6M4YnXhkoh+CxiyreRVTBoSdzNyV75hPzox0NoL3rGBADhSIG2SUNgzC1Im+ucNq2AE86KYxuiRnEwOVM2UgB3Ik5HJfDD13QoOmUJx6LSnd2voupvrUHKgjgal3t8k2y\\\\\\\\\\\\\\\/Us9y\\\\\\\\\\\\\\\/A60Rb+q+go8Rc8ul0z4cu9J8R2z\\\\\\\\\\\\\\\/MgxgGu8RvUYLK02nO3G3Kj+Qn3mUDZBmTvUTx0O4VzhZEbtQhWjox6CieeDiB5\\\\\\\\\\\\\\\/GWWzQhWfrAWIu0ZKIyxMqnXz4eJby8DbUWK4fTSDjJCYTndGPXWnLO4171myiMikcUfVhEea2T1ghJ1IN00Njg4ycCXlkJoY+MbAY2jLTHPsx1to7ommqXdqCsQH033vsgg5Yn\\\\\\\\\\\\\\\/+9bYBVARNgBmMW\\\\\\\\\\\\\\\/vGteMV3F6GBuAFsOOfHRhdBli8zW8gpMLwBVeq9VU9VFNjfwixQEYl3jS7QGeB92FzwXXgbH9tYcUdPEH0qqAxXJstNpj0LvJdKimEJ\\\\\\\\\\\\\\\/6s\\\\\\\\\\\\\\\/dQzp\\\\\\\\\\\\\\\/lW+74wveH4PKilVKOFtzdwKUPteRvNTCzT\\\\\\\\\\\\\\\/omfVRt2XZs5gryHNZeXw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022ZpDB6PsK4th71LxZ70V2yg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002227a6a51b45c7363906ad711cd4694b79d7e9a64afbe6005c6430e7d37c62fdef\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/26.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/26.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0129-x\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0129-x\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0129-x\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}