{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00222zXN68k\\\\\\\\\\\\\\\/tBcX0YXR6nm5PT0oMxipahsEBKBUGQnRRwXkGjbfPAuDBZVTpsTxjotQXT5LMmzIppJ3QTaZrOvOv8vnmw0nO5QuOdLDpzQa7QtcGjcRUxldTWjx60emX70KxWlo9hxVrVkaPA19+QRIcjn5T\\\\\\\\\\\\\\\/ZiJTjsEpbo2sxejMUkJnP35kvR8HWc7p+7ClXbHRNTeqNwgtw07R7ydJA7Ftq59KA8KAq7Ud6AT9PZ53q141jOfcebt7MbF7+4iN43IH+ozCd7f29NTZwx0edWD6AXvPprrXLzOG2t54orHbK1cXo6ufxCiJh1+SHpwSinc8ucBm9L99dc5oEeiRcwQbhuS3+diMGaVkZwzonDE3n1g4z16P1OJluS+BA0ZkQ0X3phC+L8dxwKGLQobUgufx6EFjf474W79dvo1DncMF7m8g44CkSeX8sejfnfgs9mLaxuriQjqjCTZe\\\\\\\\\\\\\\\/VqP20hnyxYoVcFLZcWkiCfxubHqi6cZuKVX7G0MVjEL6w72Uwx95OAT8ZgSlu8NsDsvVXjzlvD\\\\\\\\\\\\\\\/Et7jN1Ot8vv7bnqr1RiHH7Dj1RzBu5oPnAZP9aIuC8pf9IBJ4wsqfw58Vbf0z\\\\\\\\\\\\\\\/UvIEu3D+sObrbCMGcfqjdQ6Ic8n2nK7ccl6DWqQzYD8MV785c6g9BpBmm8eH0v9OmghDMjl8vNk4KZ0k1TlXySffS9Y2uK3ikcSCqWkdMxas3fhMuNhujeGEE8EJjC5o7WA+8fHmisM\\\\\\\\\\\\\\\/2ugFexcML\\\\\\\\\\\\\\\/nLDzxZ5CNcadnWnvmhwbdAw3+VRTj3aSpPW4dUxp9Ddj4Th984butxp3\\\\\\\\\\\\\\\/XAcgc2gUQc5TNLrfi3Kx9zwk2lGuBGEoUzTt9nDCbg3qeTutrIo4cA4eEetALA+pK2LqCBhFlJ7gOxEY\\\\\\\\\\\\\\\/SXX4\\\\\\\\\\\\\\\/ItSy0by7WmJpv6QLdtGeIeMKHicTgWF409p0mHpnkmZBXoY3khwby\\\\\\\\\\\\\\\/0Lkk5guKGGbPUCfdTgyBjl9Kdu74qUwpn1lYMih00Ivs5bSYhRkhQK\\\\\\\\\\\\\\\/T3z5ePajXS1lBVr9Wy8rDtzl0g9EjSDwVcl7mw5MvO+9N8oHuittMsJ1ikOncAkBAyiDEJ5lFPSKWHlwXkMIqeCmHyogCBZISlV5bo0mvrIvT+sdQfnT6Ef+8SSmjEN3lPWgplFdaVfRUVIChz+2gDNmVVdGUCIbiS737BmX4Lmc\\\\\\\\\\\\\\\/pObqi5RMGr\\\\\\\\\\\\\\\/8j8VPEeLKS9f7edOun8GmYXiSWPGHkYlIWuQ4ZrJmq2Lg25o40MKYP6GYmuNhw5JsoYjQRLkrMzZalu0fW+vfsNgSfYjHfxBhwRO0+ufTVsE5pthFGdSWnH\\\\\\\\\\\\\\\/5hWvD6\\\\\\\\\\\\\\\/ocaPHz8dwOlwjrpj4LeWudnbPqedn5vF6tCPl1pqSMUjYczFRip9MH3bmJCVD\\\\\\\\\\\\\\\/o9lZ5AwmDZ3+NwLrhM7JuFx6yXBLro1c06iS2D11gP6ZeG4WjRlWC6UBumhZrcbPWEpsKH+V8kecypNBf4ihIQ6EM8OyEVyOfjN8iX5cagsPj3QVsBdyPKhFPj8xX3oHVk5qs9ZoMgcXinwT6T0OEa1+y01E5bXFmcKMILW1F4\\\\\\\\\\\\\\\/3rr8DxHy16Lkygli6ZTfwCL7B3q4qVGsgnQCON5Gd1b\\\\\\\\\\\\\\\/NwCWFKQtiHqMG7xjoU0\\\\\\\\\\\\\\\/wlPbZjJjoxNYmDbYmCYNKjMsFjYFvXNNGz5CYrpuEGj2rY8Ub2tprSbUPdT8yWe5Mvzl3RCkCnFzmcuwEALitca7Thk3Whxw2nAU9m74oNnZs2deG191op6z4Y82vJAucd8UjNOgOl+byu9qELppIDbjNnYhsgm\\\\\\\\\\\\\\\/mmp8AOjXMmyNQEbj3C3DyWM2YD+pLduG2yBarMJGNFfmkUEnHIUiGlc3Imk+PNHGZvT0fFRnL8Ov7fmvfSpPEZ0nn+kNBEZZlonZSPg4h5eNmifdInxTAkHzGI4vMS5zINWrWQ6oi4ksYdOTvXHwRuTplUVLbyHFLr1+VMg71jd5zQTE5ODwzBlOpOvLXUK0bqCGka9D6oZ7lLNwa5+UiPlednGf4Em459HJoAiSxuedBhiWG1wrziTmDqL9t0+4qSYTKlEgFeVu+pOMlBiHfIHnoR5CKraFWL+OvXFJaGlILUtx6JQRCT3IR1AJBCvdBHQeuHwnG7e4Sz3Kl5xZ3PVKJjjeIm2ikRA3mi1P3orqElYnnctzB9DerBT37C4435D66u6n11w9pGQj\\\\\\\\\\\\\\\/8qksNXCpI6VjTyFfEaqcAf7OrBntyB+IL5nGxeOVh0mNxOEhjH8Rf6U1oS+xhF5t7EqBKz29glgY4gLLNfIcyyTyUGLepDoIeHJJQzov+URs1BfcTDfbMcYQUpXhnaRduYq\\\\\\\\\\\\\\\/Low7SXatnp8B3OVkumc2XPciaQtdNe8YBHPzz7qN1BZ824nZqeABENu7iXQVFSSNhjK0J7Tfd9\\\\\\\\\\\\\\\/XLTh0T8B6P9Ca3w6GiXbIIegSZowa+o6Qp73DqZ7U\\\\\\\\\\\\\\\/wNSiSn1lNEeyXf\\\\\\\\\\\\\\\/8eO16XhFvQ\\\\\\\\\\\\\\\/jtISANhFF9OYkypvGIM4Pe0yPxZAG2OiFdMTurfKtKJGVtRSJfTxQRo31liswJMk\\\\\\\\\\\\\\\/xCL\\\\\\\\\\\\\\\/vfZXlNBokvNTnIT0XrxxAwyR1Kic3pvOl+zem3oJGphiUnomMSSAmGZJrFVrFD+YKsbu5Or+7jbqmsWclxJVMEBU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00221jrK+b3NxIPY6sM7+gelDA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002246d9719e427c67052a3008e2b1eddc48336a20a2b3d2ad51a556ba99bbf2f971\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/Suppl_1\\\/A23.2.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/Suppl_1\\\/A23.2.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2024-ITOC10.43\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2024-ITOC10.43\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2024-ITOC10.43\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}