{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u002293zU3Olw07JN8pvEdVvLoMoAqcXkT9wY6hph+s0an3K3P1ZDsKpEwmhCZZFCRzl2AX3vtVfwUu6Cd3+Jyv6PoonEb6GCyUzYMWIN5inxDyrw2\\\\\\\\\\\\\\\/tCrSEnwrSDTg10IAPf6dNhDUnO6U9fdW8YTiUFWK1pgWMd3aawurh0f2kf7Ers9BF8t7VMRGgvf2X07AC23A0UcGxcjiZTwx17W1TedLbVYIm5Ij0snPkeBikGr\\\\\\\\\\\\\\\/vn5F1x+HMIIAWUoQrO+iQP99HAvJ1t2mUrCnk7pgrlXXfs4EUZIK4acjpfr2o2lbNsu5F1yWN86dRYPi1ZiCRVbw0IT1AhI\\\\\\\\\\\\\\\/O\\\\\\\\\\\\\\\/lAhOhpDRuYLyTV3nYI\\\\\\\\\\\\\\\/zRhaCJEI8J+ikJX+s+gR58DqGL3Bryo3Yb2Mp28Y6O\\\\\\\\\\\\\\\/0Hr+sSNqxPo0yOYiwxym6Th9\\\\\\\\\\\\\\\/D2JDxT346IGEU1S1oY1XYDkdlrJY6PpCs694LaRIEXk0lmaGBDFHxzwDJCmkOVDWjgo79eY65BdqrxUPEMUw4ldNyL5hCg7yJOXpwvH3\\\\\\\\\\\\\\\/1Qw+nps1DGcYcvf8GKR8sP+iJpuPBjPaZn6SbDR0pVel40NOVOkTIpuNYpn\\\\\\\\\\\\\\\/J+\\\\\\\\\\\\\\\/0ZhZ\\\\\\\\\\\\\\\/vy85edSzSTl0386sijdTQ1v8jqa0aAG7KsighR\\\\\\\\\\\\\\\/4QG0\\\\\\\\\\\\\\\/jMwKqb\\\\\\\\\\\\\\\/mjJuPYaS\\\\\\\\\\\\\\\/OlKDtayjuwUApb0hcw\\\\\\\\\\\\\\\/CbIkgnhdUcYDRUAaFSm2RMvu251taMEyUv+r8ZlZdPElyWwqTUL9iUNm\\\\\\\\\\\\\\\/9zzx1vXXpi3HTtBnMuuwLg1sODABiFob+ZJC3HifXeHFPC+xZTsOA0F8gJQp563R2nyf4F017LBpYVnb60CbjGcPh+SJHzSeOPlT2UuVPjWdWn3yalJ8Wwl2QkBPOqpgGSBpHINZz0fLMyY5bO0KeCx2P8AsT9FJzjuOdH2UFxWu4sZa+CkI2jya6nuDXi7nVZVzsoNIwZv+8wFlNQBY\\\\\\\\\\\\\\\/D7lzj1ogdXOqHZuYqD4CPtjFyjqdyvHApFm0xSyXqKNrAFLdTjXb3IuOMcoSbtqlHbYAuETHDX8WKyo6a\\\\\\\\\\\\\\\/ZkARD4cBSE+z74Ngy1DIBVPCeAoAwT0\\\\\\\\\\\\\\\/IvclViuSZEEjGoyB++eick3TUKb5WaGl1bvG+CUb26gWgr8IQq6xrSdK934uhkIVB8tGJjQEUOzmw5fOcA2x5QKxFqnkHjJozH5EXkhOLtAUPdwjQ1\\\\\\\\\\\\\\\/aUoOSQ06crEL3gd\\\\\\\\\\\\\\\/kdpDK5m\\\\\\\\\\\\\\\/s5GjGy0j0XwPuwjLKGOEAFHOVjnAJp8eP0NowDwi3ATWpZv6iZPdkkjpRxfy7aS7il\\\\\\\\\\\\\\\/zRa4LwQIrUPwtggPhBuyaP2aCoH6+T+3IJ4JwQqvdVn2GKbgrARn6A9btPhRc1Cl7hSmxUF1iyvNVlp5zJvFb\\\\\\\\\\\\\\\/oLZPevXunXqo5saLFZVPUnJi1g3D8aFiyLb2sx9bHRolbyUy+lpaQP3xz9pkQbqgn9uKTEsF9VziFFrb1LyAn+7kTf0n2F3PObF7HNyd25MLWdal3MXPhvOS1umUZnSZ2ERkB+ZSXhDrTY\\\\\\\\\\\\\\\/mZDWZAmjOtgycRCpzO1\\\\\\\\\\\\\\\/315Uo4CxTwI2Q7xLu5auhTmEjbCMJAFFfjGhSJM4\\\\\\\\\\\\\\\/91UT8qtK9XE1jcq6W6i4kQe2xujjco0ASofE1S9EUff2qz1JguxjCVWhFfpQwci91I3kzvPeeYX6gQAO0DxoILnKr+1+ctLbBKUsX2bf9w4bU8iUkyMk9rro+o+ewz4k6E7QfrmJlAA9vGErucHPefeGDi2FPM8jb6qVSDl2L92W1I\\\\\\\\\\\\\\\/j2ypTIkM7vzvNvYBsb4dqk6Ax0UEDs5DNu9Y0fdp1c8eIZK92IBj+cv++4ak87lALBH\\\\\\\\\\\\\\\/AJOlU\\\\\\\\\\\\\\\/Mu5sMp1MsNIZ3qsJuPK\\\\\\\\\\\\\\\/mB8FOhX314nUD8xEUDW9vh13sNyYbA024Fxy77fDSOop0Pz+Zn8T7hDSF2XehW5+66kZ2hj9d5FIZ2SrE3Uv7A8fKpG9V\\\\\\\\\\\\\\\/+zBXYkBOZHSSDUOcYh\\\\\\\\\\\\\\\/k6c2ysDKcAUjJIkL8u6JAq8i9st6pksgUosi+LJucF36VoeSdA8UxtJkSVoUhcdTx+5d7dJ1Y80EYHIwRzLUCHJju5TqkxSxidS3FPbIUTow\\\\\\\\\\\\\\\/7UtgcLTDObjx8uz7mbf4k0Mli9\\\\\\\\\\\\\\\/vWysOfXGw+2nb5AxclizIYsi6uHVeAm5nYAkIS3wtNPiyjxrFUSmtfVAwwzejoXZc6ndu8VgvNLZYTvnNP7ck9I8mHEwY8LVKAYC2odbFYmVU54q7nenKKSp99C6IUlEj3Gvn6I1tW0lUGyMcDy0hZ15B5WKX5H4YYLMLiXVCAV7JJNLRkqAke+yTqw0lWDiOiWGp9LtHrOCRriADc8ZarvP8T84d6kZ4s0P\\\\\\\\\\\\\\\/zljGwh0jIklxTKzGOT6vFOW6+cZYmqQQAGJe6dlFHoGBGSf8IIfh97ti6ahH3t+\\\\\\\\\\\\\\\/vCaR9+GhycV5aw\\\\\\\\\\\\\\\/DOBWgAdfJq\\\\\\\\\\\\\\\/7oezQwXwSFC9NMbR7TzzwcNtbbTu+9dq5W5xxqra2xAGbns64QPJyVkVPIhhbxiWCCoqsk10aUz4ATgpcoVNVSKqKshEJ5jy6nk9fKUsT\\\\\\\\\\\\\\\/Mgrz8aBnqIDCluATJsQrd1g3N57i2icIgsI5FsVYyjAcvBqkU2zbd3RDqXSexcsz7zhwqWL8rJSp3WuIy0OqnZ09OoQ54mE6cEIq5ylesTgws=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022ilBOyKRjj+UAw\\\\\\\\\\\\\\\/X4iJ8qyA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224ec76caf43d2ff8d7ed327b2a944082aac013339b03c787d005a74809874a5d2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/18.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/18.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;4\\\/1\\\/18\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0122-4\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0122-4\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0122-4\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}