{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022fK+cO7TxbeXVvunOULPTGKcaeutyC7fVoUmEgnagG93v4wz5a3enrHbSp846gawZf9yJxDAYqhPoFMUQnlwAgDt8A31ndArgJ4kCkOA6yEN1R\\\\\\\\\\\\\\\/YqwYZ\\\\\\\\\\\\\\\/fo50GLvS2yDwjNzkeyoEt5SMZ977C5LJM3Anv9G1PplEctjEwnPmjDra+hALmZ2J8PtS6565mPPbnpP6JyBlUnhz79BfYjBlQvOJsyGAhwUv1RX6tMfG0sfsTbvCTo2BIgFsLKESE\\\\\\\\\\\\\\\/zbaOS+XVACorQ\\\\\\\\\\\\\\\/c6NwOqZi8JQnpuRUusWPcTwlvcA+zbR0lQffkQTG6eMSadOSxdi2ucvYKcxIvCywnFGo+3\\\\\\\\\\\\\\\/C\\\\\\\\\\\\\\\/IKEg7w\\\\\\\\\\\\\\\/zwb9YkLQMXQTP1gbg+LGn5CIne7s3RMepOdWPC7tiv1BpRZV6sGNgTyyE+EnJgnrbCfqhPKYn9fQTIYMwAc6j9nik4SEJ7t\\\\\\\\\\\\\\\/ISijgl1QbQoq98IEwM0I+2U+dQaQhz5ZHpJPztRFCoRkIrU3lbUX9B5hFq0M7Jli7Lq07Frz8xGe2jozsDVHTBOWsM6g1ek8M6EzyCgV+Zmq\\\\\\\\\\\\\\\/6tyLVWzIHBERQzso1hmvxzrppPPaVn7aRglGXjYp+gIUXx3SukzDNnTMhCaoaZSpG6mXXo+HvXgriCFDZdcgTDTXlnnWfOkI\\\\\\\\\\\\\\\/Br2o+L9JDZ8N0c0eDEBeagyZwBX0U8\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/lpI2MG+Ht0adlKPENk3H+Wl3iUliyfGhTfuvvvtcahdud2qvKhmobWaSxAq0CyKB72xES0waLNzEqtYJ5ZS+DEqpwptc6Igw6bbaVa8iddIFlDKS4wd8n2d7Krkd2qjaVjqZLSHEC7Wfxz9pwUTW870HaXwLWMZjxm2VYNTTNEp8tL5IRIhGLziOsdCCkKCGNcMEaWshLwsje\\\\\\\\\\\\\\\/VXU2cJBPd9jH1ZnvBKF4ft13LWM5rL1zzuKW55\\\\\\\\\\\\\\\/blK+az42JXURprqAOpFsPx\\\\\\\\\\\\\\\/U8osbYNg3qikgTtOO2cOMyA4flIj6pXCe6wmvM0S64cTj8n15Q7K5HtNzZ6OM7Kw13dmaXfGqUEC1CwbWEIf4bZScmh4u4YCawmu7tgMrVovyj4rKncyUtW37Cz2qV1s0rAWOnergDn2yEZBqxnOLCTEfjhgce\\\\\\\\\\\\\\\/47DWOjthaEtMChkaXf8KUsk1sTXCL11JaaPtF0JyZ6eMt3jbJNHusOPNEpwQ1rxkL3N63gcHL3+FLq7i4e72lt6jXI+ShcLnGZAdg8QZGmRoa17IZIzvUfJPZjHtYg878OPQQIplWsbW6b4y+rrImePxOBofoYHHBqbNvxUdQaSea2HlRC98I1hrrKtX8bs2aP0LvT11glRUgNRXkpv9M+SG3fBYiCujKvjF1WmfHd7DRSRxkZPJaS73HlSUaiz40krX8ZKdZ1PZ9BLbqQa3fPNw+YP9W6E2b5BismJfBl6bnheeTWin102pVrdip4CyunAI2mVx0AYN0E7cATVoJQY3LSPW4kXenAIWKqkLfMnjESvM+QlHGsqp+GFq4ZUX0M35\\\\\\\\\\\\\\\/1S+3Qqm0I+ktFE1WFciBqlsxwHKfJ+WJK1\\\\\\\\\\\\\\\/NevUTmmEqjsF3qoLXQ0rjq\\\\\\\\\\\\\\\/piFhSgr5KEiZ5aDaOL3GBViafE9Ir+ci9PoztE5PilVJpp03baTYPzTGQ2MeFGbrURRnWaBaCIbHcchHeBj2ZGzZwyubFB+tNX9ly1HKZjYI9W1ggyHxkXtGPL3Brd2WkZe7mDId6mHpRUatrjjKTCjj7IBWRwImVXczBCth7CVwXzKsDdgirmXdt4LT6AuqTSUgFIvH48x032vYpyeQFNdXWHv3ICfDk0eCgWLI+XWn4\\\\\\\\\\\\\\\/dsqGRsk\\\\\\\\\\\\\\\/ivpAl7qDdo4hG8gW7efVd1okDmUtUXT5WnvVg+3o\\\\\\\\\\\\\\\/S8gUOE+g1ApopGJMH+VhXWABNEGCmFJTP+RLuEo1Ixf5BhxG2q6DVpH63b7mxKPwfsrDOB0xympIOw0arN6rsZDfsgJ5ID0poRYel+VhUTVc2J7KX7c6PmZ7U01f1i9aVK9az28uZf7tBt0PTVm8sQjO9lqxH1rlNT9RWs7sytLdMqq7eXJ9HLlpxQhG5POs4723zII4e553rO172eNasc8A5\\\\\\\\\\\\\\\/MkuA0+3LE3KNvkSYx8uTX2GXF\\\\\\\\\\\\\\\/veF8Tei\\\\\\\\\\\\\\\/jkeNEb+IJhkPWEOeTz4NjzRcJZ+C0n4jWHsyrBKJwfAJBM4Kqn\\\\\\\\\\\\\\\/DRyvQcFNXjaH3SaOnQdety5gc1+Sn0vCAZMKle3klwfSWvgd0wge0xYE75\\\\\\\\\\\\\\\/52YgDqRORjD1iQ0Sx+w29kmYPPI9G5Q8PiSkp22n1ATx2rdTFDgrQwkH6a4m1kf9awpnuELfBK2ZYXzWMs2JG86lRWvdYDSwqG4yWZTc5Mhlywp7OMEAnqTh91EjMRyNGhjT5htRpH5sAsa0zzbkSxgH6Bx9z0kEYqIATirLnXCdX8X6jDKXPJy1hnIaV190byQmgfprqIyiRNudRiSoxwUDxJIDwzmVPdSUQgPMLuFVQuVqKaOiJplyX12lJm58yPCJosCK0fvjgRA8i7HRHOTmsMxxEmbe5YlD3U7wzPh7A94U3Hjj6zKV91AVEgdBZLeGioXsg8sG6sR8I8NMXAWzXABHI9f29a7kCoPaqbPmWARq1Zclzb9ufAlyLXuv5a356JJwVEVE9Y=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022O0K3wN6WJ+nNUUnfP5aziA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022bc2acce6383f3183b1fdaa04e2a5139029e2c47275733f9961079c443866e18c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/Suppl_1\\\/A22.2.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/Suppl_1\\\/A22.2.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2024-ITOC10.41\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2024-ITOC10.41\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2024-ITOC10.41\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}