{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022vCiMzd+RJOsW8RzRFutQKCFAA5ZmKvjrASrG6GL3viGpWakon7wlvzpXB9VHIBC8i3Rk7ke\\\\\\\\\\\\\\\/uWzrtFvf4Ki7xNfSAtT9WYiHNXv81jRAuUsRNEeoa1hr\\\\\\\\\\\\\\\/VBHP8y9ZnXrRF5LYaC7BpXqYQLJqc2Sy+iD57QTYkRiGfQibfm9oV6GNBU+RvmsV6t3qph\\\\\\\\\\\\\\\/E+uQ3ieIcHBRRiFnLd7XGdYBF5gYbY9QDuwtKdaLptmvESoiZCmwuL5r7G5sWujvA4C1YPgap7jt7aKKNIB7ep6ueqZgVF+EBdmUHqdNWh9hTSK1s8yfEtztSw6AVUrsmk8F3uFaCjltdzD3q2a2pOZCYV7L6YMF3Eenfl7lj7xI1p6IwOqFVamn2ElKZ8MM0e9NHXX5Wj51YWw06xPqeuiLVUCEF5S6QbrIrqf7xepIe59qSsfpNxGRi31LXOioRHTvlwCXI9Htlm254YWfk326YIQ5aqBqbENd9RsQm0XNXlQKPTBI1kKFNivZ4kGuvpshtoAfHwrOMuyIkT+yqidI3JQd8RWMMenqldr2xTCxLfrPZJc0o3vEdXnoGVusMJZ53Q9EkKgRFQDWtEipgeJERfioxZQslPOthgT6yLveVfJYcOJPZq3Itqq23Do5nkR0yzYcCH9w\\\\\\\\\\\\\\\/3KQjx2rjfEWVpYQfIpfH9Csurku2nOW9\\\\\\\\\\\\\\\/2BbARg238rlhNmMdnJZm+Usyx1ioK1SiJWbBYTdCtFRbfCUAc1kgZSSEg1qENF+u+IhK95K11b1M3crDfrEuxQbEqSMRKWdOscPN0bl3WgwRmpiFg1SdHWlLhxZsbUl2LHySo5X5irEpasn9Zy0yzG77Aym6mumSsgzOyx7fvFRmJgrcEANwOiTt\\\\\\\\\\\\\\\/7SX7ugrVjLS6H1ZgLGEiOO0r8kg3fUwZGOdCkDV3gAChv1nR4jG0vyffO6oF1P0ghbMxC3G5oMushccNr+qYmZBAFMwFP4H9hp2ArBEH43YUfZoFOSWe6HqvKYqFl\\\\\\\\\\\\\\\/m28Ej6iTcT1SqrIcpyhz2FeSjQGq3v7mBo4wMFitoFYYgLTsEjlDqw1ksKzWqA21Z\\\\\\\\\\\\\\\/k1EhUUSFbFAEqwk2tmzgvWkk80GMH4baA2NQk0a\\\\\\\\\\\\\\\/nnkxkkD\\\\\\\\\\\\\\\/fTFnhp\\\\\\\\\\\\\\\/LGFzVMWnudWKoIblb1OMjxgyU\\\\\\\\\\\\\\\/0IZm3mR3jH8YtEEvokQcIko0Gq2ZhK5ZFbc5VkgQC1LCLmh7jCYWERq28YnCI+iisHyK7Rko2fUJ78MF04N6HVy9TWYmNgAj8dEaWTLYCFW\\\\\\\\\\\\\\\/Sxs7zBAGux\\\\\\\\\\\\\\\/1bhEfxG4Wzxv98bQVO9AtIhBAC+fPG6cHJ0H9CFGSQkrxyQ48CMfZfB5uDnfe2XSP9a6AGe8AjbxAFS4vrUJs9fxKBj+3gRMv\\\\\\\\\\\\\\\/F8Sw3lI\\\\\\\\\\\\\\\/kKroagRwLrexiQxUBfm6rlFbdqLDGZzmtmQOayit6nF9d4XtVNnC4Zf7rfdkXQhdRpgz\\\\\\\\\\\\\\\/gXfm17Rg5l98ltRTdsZXV+PCC01\\\\\\\\\\\\\\\/RB6Yp9lynZht1jcohu8PwYFgyMX+Yz0uQ\\\\\\\\\\\\\\\/rfzpG5nznyb9ZvA6dDynRH\\\\\\\\\\\\\\\/vAaCznrXmChtaWFzxm\\\\\\\\\\\\\\\/lPStVWo9qdTkbjCN8+4qKdCf6y8oveBgDmmcHy+fCWt5rYAQjUNmsg5FdJtbB94r4pWl6HLU\\\\\\\\\\\\\\\/2I4mU7tfPSNa51ItfFlAMcgcAD\\\\\\\\\\\\\\\/1GFBEtCX6AFHnb6J91ZL6oaBzt+58882CXQ1do5ey7LebNpkIAtARKnUVDKW8FokTEKoveLnlL41HyxGk0ZZaTUyov1E3LAuTB3Hlv61Hut6+uEZKc5ABa0Zq6V1PClm1cq58ZmEIxoWJZvLwkFd45fk3xW9XOXJq+MRK8q7Q1A\\\\\\\\\\\\\\\/y\\\\\\\\\\\\\\\/giLnxUznSR8AVO6Y9Rh8rY22V0gflx79hGf1jPCJAmuz1rjRKxNy5k\\\\\\\\\\\\\\\/lVlSiX5ndKAOraVSaCW0KdDvvxpF+42vsW909SbOxrkGK8F+KWrj4kkrshI9Ou0UqF9IYWIDCc7DOI+rmcZjdr7FIqDmwmrbwQytO6EJoFgKJqBAuwfT+1wgrdoJiw3Rqm0waJzWpZFhgTwoYuWnkD5XA\\\\\\\\\\\\\\\/iXHErASWU5Nu6Hj7W7nkPBT6sBLbF3hE7rV\\\\\\\\\\\\\\\/PXHNbO3souUDVj2ddNWGdGnjVw+pNFUJo4UqpiXWvVlH306lbFAXXRqezSkEdzp3XLF842pTXc3ttOanyWcLbLr0zJ9OMrGTzYZLxUASX+RFkPUg2fJFB\\\\\\\\\\\\\\\/5XYsoK2aQKiHk4RtXMOscbsJK6438v5h0rMI\\\\\\\\\\\\\\\/lPnZ4VlvrJdZ2WCECL+fG+wdJnRMRVRtLuW3abJhAq7faDV\\\\\\\\\\\\\\\/3mnznewL1yKlP0kjxUutROiy5JOEFWiS2u\\\\\\\\\\\\\\\/DlHUstjQ5qi\\\\\\\\\\\\\\\/42FpsxLJlfMwikMlfz62bMagYAWW54jiDYzPo0Bi4zofQUmtuEAZwKUXhgm9nG\\\\\\\\\\\\\\\/bzkx56xBIPXd6BHJ+W3DhNMjFRnrz5bks1qVWV23PAphSA5hi6pVkOwP9IQ5fre2H4hvODIvb2K2mKJlIxZU439Cng23EpUWs6kSSVR+oMT1rRzAz1ZVEl5xz3sSFZs8QQwmMNOMag65q+9wfT1eu19BkVr6kyjohyg2WHb+Xp98joIapCBlKQ1ArTDYi\\\\\\\\\\\\\\\/oenoOSznf+yMiXMBHsG2qsvZj14g8UxBctGFNMF3fcM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022iHSmk2N3UZVPO26xI++3Tw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002264dc691886be2ffd51b3f3aea6fe69a3ebcd1dfbf8f3843fcd16d62ec50da7fd\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/52.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/52.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0155-8\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0155-8\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0155-8\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}