{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022EC6Sb8sa44pIYXBk+353VahC6x2fDmnsd6sP43mwZXDIp3\\\\\\\\\\\\\\\/0KgzAtq9vJpf4JsnrWPosRCdnnv9Wg5uPUUge+PaPwW97rV7eKdFvg5ZUnqWnZW2P4N8gW\\\\\\\\\\\\\\\/GVF2k4F2Y7A4rlIYqF2j3TYveYqodyZw3cUrCxW59hImAplFi9\\\\\\\\\\\\\\\/w\\\\\\\\\\\\\\\/soBRcpBBZqoybwxPYLJTziSgGMkP0ofhcUgsbS4Zo6bSPq50\\\\\\\\\\\\\\\/rkiQJS+zwuS7+7GgfCLpdfB2dEUKTJDyZZMrzNwX741OJ\\\\\\\\\\\\\\\/YBjmgIJvhmUCr059c0Xj\\\\\\\\\\\\\\\/Hi+70saMp+p\\\\\\\\\\\\\\\/KrK7pP3ovdDOvdz+XB7gGhorM3pQIu9O\\\\\\\\\\\\\\\/Jjh49OZUSAYXrtWWhR4OEUnFB\\\\\\\\\\\\\\\/m0vNIJuaG+R6SmpmAavQqud76duXStB6aD5mfuy7kgRV9we\\\\\\\\\\\\\\\/y3Wa9eSbQjSgk8FSOnzRENEJMfmT3mzeTFtrjCuM6WVjKbEz9RVkbColA208PCCMcYoP6IH5qhYFJNlT\\\\\\\\\\\\\\\/dJ7Qj3SG71Pd4LwTHzUYdWpzAt7Cj0koC\\\\\\\\\\\\\\\/zE1ddM9RsG1UT8\\\\\\\\\\\\\\\/HxXensKxJBDepIPG8LAxZDaiMA2D1kgyBFbUf0PfdwLtFTeduwP8Sy6NXUDtGO29W2AHJd8r3RXPxSX0tAkkIt8uEd5wJPomJ2qajgskI3iyePOE1VmIOb3OIXTljopZn3ffI0TfnKNYZr\\\\\\\\\\\\\\\/jRQ+4bTpcrQQuFhtCVLFap+Wj9wjECvz5vVM97YcDJnIJsMqLR7ZzwVsOdXQvVzxEe4JvNorpC9yy0P2SnAOGY5B9WfTLvelz5s7VxXjE3aPt+PUZrOEPTgrUw6zSeBA8A+RknKOQIFyv6yfYj76AK65Z+5nq4P6OjLwZTq0tC189TGYDMwEUhefd+n7JS0RlvTswjpymjyM\\\\\\\\\\\\\\\/GY+44T6O2YoREiyQwEIikLr0lqHoHBhIqZsPoXYI2aKipTPPUFbm883rfD09eaoRwGPvjaKFLBp0Prodcvd\\\\\\\\\\\\\\\/vJdq75UYrwsX0omJTDqyPaprBVxeF+ExGCuRI4RJVy+c9he81UAfYF+ID8qkk20ysRf5\\\\\\\\\\\\\\\/YT+z+\\\\\\\\\\\\\\\/0dEJoJRUjLTdQOAf4j+gYNgjRTDZ0\\\\\\\\\\\\\\\/D+kAPA2OtAizUK6u+wn1d96jfRgvqN7DV87sJOycSpZaUCzeWQTpRhELn0IYp1vqv76\\\\\\\\\\\\\\\/A3FQvkjtTTObpwLmRLls8p0AKuONiq0BOdLXKAPZPDMuWKIJxMXpF16HlkoVkcxAyXqUJUWfwxWITkjWRc2HexRgizp4OS1AiYAFxA7k5Dcwp7pZMGNE8ie1eFJhl5woW6t\\\\\\\\\\\\\\\/5FUooQ3FqSWoRnSnQkZ0VYbXcnHZDyV7Mnwj25bk3AX5sL4RvCld1B++oPHW\\\\\\\\\\\\\\\/waW6hhRJofWPcLaxqDHFz6RCicZbBsm65+nq1M3BsuWS2ruTdeEQdSh7wdKLIvCqJD0lJE0zxoHpa3qy+hkIGt9z42Fbppbw0HW+fs85LhRnzWBCO2axwZq1li+r95NjctbZd8Ei9oQy0+LLgZTw+j7RA2V\\\\\\\\\\\\\\\/vgoYblXG3O2Ha9Slrzl2uPiwYwNIEohSdWZC9reVfq5wzcsteBC7Mqwnkl22ZC1ZaShjTFG0Ylt\\\\\\\\\\\\\\\/ULxRFuAwmPFre5Op16tSwE8lG95Jr+gUGca8+m44hPTZzKwohDRPunHLQhwQduBNKHznHgacFksoRCV4g3Rh6UTVnNc6yoiAmUZ2K1UMBrM4AmVbQUo0hNJaoirFHxbohYrTcUgit7+iV7LNVltZfu0rpnkh0VBUf2ylTf8caiv2FJbvU2eVmLOgyjlOSsmd6\\\\\\\\\\\\\\\/UmYilqvup+O4CNrJQjVniLcx0uEEUAr5J0H1wEj9bAu0MMgcKkbyFxQzpBhwXdzN9yurGFl00oSpO+LON3b9e72PGNYfbbM4ZBgX2GcP8lUNoIjqixF6W0fxUgBtZL2Wfib5X8msNH\\\\\\\\\\\\\\\/3JxJmn7\\\\\\\\\\\\\\\/30LBodNYPwn\\\\\\\\\\\\\\\/0U1BkPN3LhoHlq1g5B9lVZATuSzZBMLqCcwo57J+7no5qtmYpQL3qhm0fQ7mxW7mRMZubpFl7rpoQzk4I04xrgin0TFVZ3D12hp7374G32d96qKW5zWivOLJ113e4QWTNp6kGDqdKtuDq5uxCAnKUpK9d49tj7k6WWr1IAzhCFFL8Ue3tNKuB2ZS137kp7Qk4WFf2bAnsW8fBSy06qOn1nns7kFiwTJsveE5B672ZfqUDiMuoqeH4+6AGPSmaCyQKxXapau5WFMgd5qwp0QvR62yGgR6S1R8Qlvo04zstOggbEQGWjOYLXLLNaeqN7SK\\\\\\\\\\\\\\\/RX8rOu7efr9DwFNXWEGOA6D01zOjZQQO1Kl1+U45iBjOyZ9HHeT47+SlYc+tcKxieQGL32D23urByqV\\\\\\\\\\\\\\\/YXUzyyBDGDBcZT7G3mvFQShoaRsZatoI\\\\\\\\\\\\\\\/X\\\\\\\\\\\\\\\/gSS4WQXhwXcbD+GyuCmZ3MSKjER3QNytygvvHOMr6EhmlhIHD80vWkIfaZEetHmOYl16W7FrGKPl7pcM57iF6XNkuywfBfzXGA8uD\\\\\\\\\\\\\\\/1TOnq8WK9RhyqWN70ktmrP+lznINM8HcLbF8PNtgT47AG7f6TIC85do+Wb+EFyrQWouvvOYbucrLqN5qJBeNWsa8iG57L5f9QwR5ZwDG\\\\\\\\\\\\\\\/pYjQl3mbR7Jw8z20oDBmvZ89adNHHVTMzu0XOKgAo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Fvh1D55yD+g\\\\\\\\\\\\\\\/qG\\\\\\\\\\\\\\\/ydIF9dA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223fe0b7137e031c51b94b9daa9707aabd3f06dc657215566eed1713c1ba6482a3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/3\\\/e008295.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/3\\\/e008295.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008295\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008295\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008295\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}