{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022yAeoKgPOpc9ktxdVY0WZdmmxUmSOn7csPkAyRViDJL+BBLaM39vr3BGntrHJJ4NWoNUhgodDgZR+lSOwKQDEIs+sc9lp6gFM23gpfTh6TdQFS1YnDIszky+9NNaiu+k\\\\\\\\\\\\\\\/xL1LUX14vFXXNnfgyLKEPN9kLCATHzNJzvgchJH\\\\\\\\\\\\\\\/ijctI\\\\\\\\\\\\\\\/XEtB2qj0yPgTUPCTZbPxfVi2VpGI5kWRr407oQA2cWIY\\\\\\\\\\\\\\\/fNqjVhGjQAAVdGHfj3pDsxlTtyipf07UOaw2J6u7JPmPH1jXhl2jrTYwBWHaqO00PhXCQhzTxPiLHTWcPkM9v0yC96EzsaAjpVkXB7xO8mxqqrRuE+3pBa4ZlTWP8bmo2rdGswaGF3p14ALEpurNuQoDVPe79fTKSQPsXw\\\\\\\\\\\\\\\/uiKx28Zcx6rMUXHhEVXS09CWzy2xbLzJnztyGLh41Fm401d0OWW1yrvNwo2MkjRF6CakH0KCuRMwVVPlkhPK7jW6m4viXC0AKoRKU2ip0inlrx\\\\\\\\\\\\\\\/9H5XLxRxApxThUm4\\\\\\\\\\\\\\\/lJBlxT14\\\\\\\\\\\\\\\/oOkQ9P+TQUlykzdfVA1NMCU+pLWIEM8NMuk40GeGbfVf9Oy3+KWy2W5F\\\\\\\\\\\\\\\/zw2rx9fMiLxKEJwsCuWfRdNPanXgEI0KyiwMz3lw+vmKUj8\\\\\\\\\\\\\\\/kZ0HKbLhlp\\\\\\\\\\\\\\\/w5H1JQyIhRgXxCUqQn6fzfFeYiUGLsicrkPWL8Pyev2oHJ2qd1RH3KX0HGvq3JYdEceuEj9+VrsJgvf6zfyXCypkzIV+Ov4RP6rFXXzPcRHFujjYO+0IXNND8rKI526bsMZUSfeJJq+NFpFL23jK4IRvVGbSHOfZZAjapALmCIhOwMSH4GBRm7ZJrjnvJSFq1bTxyL9FWSrPQ3aywxBTW6hFcu+5GMRTtuMivV1zvKUoPiOgEcX4uzrqgc6w0CWOJ9Fxt1HJfzf\\\\\\\\\\\\\\\/w+8ecpSebSalswebLtF9gZlaqF3MrpcXIUprHY+0Lc\\\\\\\\\\\\\\\/B9yMnrLtMUgXJsFKInty4jrvd544uX\\\\\\\\\\\\\\\/Hh2+ziMLJ5PorIohEvrdm0vI2VASbUNjowDuIXxcNcHJwfQrnkqP0CDck5ml9\\\\\\\\\\\\\\\/hrMHvafuBlgprtm9VaDQfKsBezgHwYs7sb\\\\\\\\\\\\\\\/LH0voI4qOeuDIYQVEk+b1gBPPf0pc87ChfbVtPqo90LA4PqoOaIiQNQfdvjou15wmjKjWJEkFg4NUHRLIlt+jEafr\\\\\\\\\\\\\\\/0yGyR+cx2S\\\\\\\\\\\\\\\/AmRKC7xLQ4T89hjooUwo4U\\\\\\\\\\\\\\\/kMXGTxe9taH6tYa05r\\\\\\\\\\\\\\\/c5A7BsNO9penSt7su9CeAQFxV1rNOkYhgjIeILJV90FyVcoa3WlxsALZLV5Vv8arsflCHuA6G6F7k82j8tf\\\\\\\\\\\\\\\/6\\\\\\\\\\\\\\\/LjRlZc\\\\\\\\\\\\\\\/5ntd1AFdVSIbuiqjOzxluElW6smn5HPRPX80xZFDxgVo3XpgJYAYgUQyVwfUq8WoSBcQ\\\\\\\\\\\\\\\/BjJq6Ff1yuPVnn1mnZQWTutGj0VJLqbAA6AoikA7cKJGZr4yesMjs\\\\\\\\\\\\\\\/1DcnPDa\\\\\\\\\\\\\\\/ROz1qVJHbEYN1pWTVI86FRAFpw2exuA2dnzJJLSE\\\\\\\\\\\\\\\/YjG3ocH7Apdqdr+xZ3lOnVhmEJ2l5cR\\\\\\\\\\\\\\\/UEeoEUqnx0TFR4irz2Yh+ac1EG+fUK5Fd9vvRVWZwVJrrphC46FDaF04xgq8OA47X8NcxefSuBORmeleV8qd7ibN4ECmMLE+gEd\\\\\\\\\\\\\\\/aAEK17uZijl157etDNGUiJ084i6nbP9c+k3dIFz4xLl97p0zrNGRKcfn7QIZjneSy\\\\\\\\\\\\\\\/736JJ8NqrU8TyAILTKtlRAcfs\\\\\\\\\\\\\\\/BvglMlPLAiH1Z8nYZjcm5MEjSfZAsQh1rlSzN0bVKr5f9XUFAAOZnZUwzKXYfha6mK8altvPBFfQScl4DKXae7Q\\\\\\\\\\\\\\\/0eictvsISlb9aHzxmL8PhuRerzR9Iy6LbpznSg71YepqwFniqM7mKIqK4kK8ABuR6EnDuwOZqE747X3my1Y8ABAZU6KDoQVv3dSdK4GGYfknm7Dmg7QvaXuAT40pq3Mich05FbOX\\\\\\\\\\\\\\\/S2o4sd99WEzmdUQv7COpTxgTGRRyMXT8gUg6CM9z0mLh8BRkbX7Ocl\\\\\\\\\\\\\\\/k4Nd4il8JF2fW3QZukauxYrSX4gcwR3XQvmDulFoZrOZ7T\\\\\\\\\\\\\\\/A8GI4s8mxaV+ZVCdy1T2WditV0klUE7ZWy2Zfrr19PhXUYclFoCpwAUCLDHZQCO8yv4rmwN9ZOLKPsw8s4Xoup0booX5MojZqFz918xLm2g5\\\\\\\\\\\\\\\/xIlD\\\\\\\\\\\\\\\/ofAVtntjJ6BNXm1nowLHOVLySOXMGyOoQHkxOeDTZSX8REz5+sBtiozmURe22kxnXYMvz+fINhCcFgBcPBiaPy2obdrkCLvN99LVrSqlpakPYqF4Hfj4KJEaQn9V0eI6A3NU17KOQXSvGXgF63g+ulk1hHZ0mWkdjD9jx7I\\\\\\\\\\\\\\\/2mcO7\\\\\\\\\\\\\\\/+sGQmZD7hwwIQIH2RXNmEJHYLH1Z13tvgqUpn9adq++nD8+KlKn\\\\\\\\\\\\\\\/j725SDZ2aWoAU0gKIC1Bhxu8GjGeyodZ5boZRYgSYpmhBlx5TWYUdEkx8O9Bu\\\\\\\\\\\\\\\/rUDJX4SWDntIL058FgeY7lz8OpWKPLyqMJBgaMOaz8Gj5YETmkY74iNNl5eLd1mR9h9WmdwbZRZTcDiCuZp9LQiNnuGdArlGOMHoMpx8\\\\\\\\\\\\\\\/CxWhNyUfECNgdKO+Ho2DQR3ulX374lU5n\\\\\\\\\\\\\\\/uEJxDK7ggX2D5UqEVoQwcIqqY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00227QMjlR6rIwWMa3kLCg\\\\\\\\\\\\\\\/eKA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002233c47e6fabf25f5e999275b00bd83d359ba31e473616108962403aac1a0ab1bb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/56.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/56.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0160-y\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0160-y\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0160-y\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}