{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022neVGOOt4D632ug3LoKedC+oKNpKzY40Vrf6IbJYL0Y\\\\\\\\\\\\\\\/fbn4ILogDw25mLxJr5a32TFvyAKiN\\\\\\\\\\\\\\\/Z0g1YOc3GYnqTyHUqzVrnpOREIzwyHT+vGiINmdgPQmUgASBToUjjBwq6GklhZQV7l1XzPP2I\\\\\\\\\\\\\\\/8RvGNILc4R9umvvOaiNxhdoDxFQeHOVOCSxY0sP1IhQOXF1UXad2PjZQhLj+POo7hcziSu6OgbWQDM\\\\\\\\\\\\\\\/8X12y9lM11+EKeJ2tl7CLZjlgfrasl5X0zo68AXi5wxp469OQgjPbW9PFAGDpBrd+hyQGejj4uRKO0qepFEVA6HJZqpc+TinM4nva+8QodovxLdGXN\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/SPHVI6gHizUQMWDiyL+iFsswWNVQgB5K2CsWKYh5hiK3KL6E4J\\\\\\\\\\\\\\\/KAYC4jCJuPF0BxZxyFOeiHs3l8kgV2jCnJ3Fk+rKp0\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/DfoTS3RkrWtaJJ\\\\\\\\\\\\\\\/wNaGL6eZub1WfekOxbMn9RPGC\\\\\\\\\\\\\\\/7Tw\\\\\\\\\\\\\\\/UGZLgCd\\\\\\\\\\\\\\\/8d+PsCLJdARaa0Ma67Wymj\\\\\\\\\\\\\\\/5HIyOoQaw4iPAmVIIvbmiPoY8xF61Zb1cyT29dhskm63P1CYC0NN8HJAVUTP16y1Ycuh9Re+MhSNz1Nx2lR07v1eLVMN8Rt33YdG9CyAsmTX6cUlW5I3ZTk3AH3Uf+LTmMHYz4OuR2gRznFiYB34K7SR1cbn+XoEJM4GrYdvC2mftFur7XK4UFIS6hXTaaKi02MkZzf0rdN3ZFIEHD4vGWjGT3r9pSrm0BCjl\\\\\\\\\\\\\\\/MqnCj0bwjOltzB6Cecx8mCvdLjrlJQ5XyC+Xo4SYoomNESm91I+D5n0uXOYkMD72fFvlpQRGRZDsCNzO07rRJORuWKsFRigrt6jpzAMWSEtnzgODmaMCy6uyqmkfw\\\\\\\\\\\\\\\/erhwHdU60sYFTxHYKVLb\\\\\\\\\\\\\\\/jGOsjyKXC\\\\\\\\\\\\\\\/T4bQwKPBXWvxZjdq2CtlaFSKOUc7obrI+jHHSuOGqb1R0UaH5FBZ9EDj2UfViwfaAjpa3qqPOmF6vZxwumIs\\\\\\\\\\\\\\\/ufIRVPoIJb2brPvXBQiOA6otbeL9dDpEx4aLNde10mveCGIAuJt8lzOf8CvZac\\\\\\\\\\\\\\\/6d6e+UI2\\\\\\\\\\\\\\\/QvPB+XAoxHUMd+16sNRZ1nnTWP8TNgLdMmANTCEwlAo0zlvKI5tawkkqhhqzGvr+ep8frtN5FVH+A4xpuey4jN1y\\\\\\\\\\\\\\\/Qdf4gSpzPJJHL8T41avq35THfrtDAr\\\\\\\\\\\\\\\/D4H73zEiEaCSnysmbkgDdEdzBEjOx195sukKwVwH7C\\\\\\\\\\\\\\\/rAUozIkcm3n\\\\\\\\\\\\\\\/uXAVMgtiaGrw3gdfvYo96F4T8IWkNeZ+Dxg8sQ+eKDaFkKHpP4ChyNicTJ57r5ynSnqG\\\\\\\\\\\\\\\/l3W2HD4rZEXo88mGpgyaUvZMd6h2aR7yOcPE+nb1MbRtZueGWpDRmIaEgTRM47K\\\\\\\\\\\\\\\/BB02uT1YjUhDGzeQtYTvzWYX2\\\\\\\\\\\\\\\/tRNxasmz1OqQ25D5OVrhwNSr7p0ItYN1R779re6Zgch2glCOX62mX7Ek\\\\\\\\\\\\\\\/MEhESpvmEE+8eDLRagO+gqKKUKQ5kZ9xU50zpbBIUuMVaa1G44Ob0FyqU5qD9wy+AbhEANFYK2HY3sGi8dyTZBFQys5Ge2rtGpZZ1A+3AVwRnmVM5RxHGYG5We2k8Elg6flsYvHTagA9+2K6FL2NlURhSYn8xhUYOQHcK+OILnUV7bWqotEm1SUjwdfbOOmFKl\\\\\\\\\\\\\\\/cIrSfqSfWyvB+EVcCCKp+lhiAbggbYBjltX23EHt3kbTq7upDnrFtXrlrwnKcwSfvi7N2rH\\\\\\\\\\\\\\\/WkMwrUcmyithLdopvfuTzCtVAbm77odkwkDtuEP5St0BI9ju4s\\\\\\\\\\\\\\\/3zHhkIKldKiSSR7KaJ9peRoe6qLB1\\\\\\\\\\\\\\\/kP2bp4SaLZv+51G2c8bR57oxeBspjEPWJz8AwP5eI96VNk8+67lsEXg7gWXqAtThfw8H1rqHadQSG+d\\\\\\\\\\\\\\\/hTtd5GtCGeBCMEsJIJURRVQMALZkSZip8NL4iJUmyieEupTg+53hDi\\\\\\\\\\\\\\\/94hHtrDtJxhNNpIu011SNb2qMBNj6+oG12JkXMRQzJOKudqQgtudFt2kGSeSgHhps4CxDEj4wPKqbOsVf887MY4XfJ0SH27YBWGpPj7gSg2xeXJqq8btkVWlStS+BcFQ9qQy6posMWcXkD3zqLYieOi0NNHb4VQbyi4w+sxymp4KJL9VYAs8Cpz7PTKZJW8qvwYRAT2n6IBmb9HNrq87ae74fslMlSN9uRjJm8g0bWb+ppdVw+U7sxEPbE+DBcyJzNHYVtIXIHA9Donx4zwdvvPlpbE3PgDchDusTJ7oURGATbPJH7uWdHi46wb\\\\\\\\\\\\\\\/qcsGlrTnJWA4JoVGY8aw7+cZD3ieUlx\\\\\\\\\\\\\\\/MgIyPS98q7rkBByO4x5jXxPQn77OoPSG4S7mqLVWwuaBYGyd5xsnpAzlRHYsZFWLSqszkQ6j+j3xXetqFNtl+Dd\\\\\\\\\\\\\\\/3HrRU0bhWE4ZYymWt7XsqBeLkeZayhIOQJnEOkZt91vSmhlR3lh3xJPm572\\\\\\\\\\\\\\\/VxVtBf22CtDL3ladB7TOI4EsghcLbnCV8mAK+vm9OmKpoz1NT1maLVI3eUXARIrG\\\\\\\\\\\\\\\/M\\\\\\\\\\\\\\\/+WfeTHdzwbrAeIVWOcTbkQ9Dena+LtT7NoZaPRE\\\\\\\\\\\\\\\/MHVM7Bu2ZrYslAAuE2BgZR7oAJFvLAOo\\\\\\\\\\\\\\\/Or\\\\\\\\\\\\\\\/Cx5WgTtv0UemtfuClvqi9dwg8Z6XQQ06U=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022rp7soQBJJm7ZeYp7Xtod\\\\\\\\\\\\\\\/w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022cf100c19d84e286b7e069512719a0f1d2c0b7308eb7e838475060f0d6f48e5da\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/70.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/70.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0176-3\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0176-3\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0176-3\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}