{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u002272CAIBX3fT1\\\\\\\\\\\\\\\/B3XpZq\\\\\\\\\\\\\\\/cqz8a41djt9ypuN09R5H8r4Vqh37lJ08aLuEuTdbQsZ60bQLqkAkSBG4KbD7kjs+x2fFsRvNL35C6lvtEAqn7tzEt04TQ4hqkgJiWPPj0Its7Pg6g\\\\\\\\\\\\\\\/N5+K2iYwsksTkBgOV6nHhhJQ\\\\\\\\\\\\\\\/Nxg9L1zKelaNs7jk7EcRdmpnRFwewkVRWvm+rP5rlrMkWWYP4k3uYKL\\\\\\\\\\\\\\\/tX00wXe9C9Mn2ElMdYZh0AQlvTKALyiZOvBUzp\\\\\\\\\\\\\\\/rlj46Ex\\\\\\\\\\\\\\\/MKkg6z0a9txFdk\\\\\\\\\\\\\\\/6SH\\\\\\\\\\\\\\\/xtqSggd3xccMOZ4C6+mcVdFkfHAfASS95BVk4nDtCHimb7WrH95\\\\\\\\\\\\\\\/wuuSBGWBl+Ah4FKUjcTZ59w0O8Zk7r\\\\\\\\\\\\\\\/fhkZik6cTcyXY\\\\\\\\\\\\\\\/N\\\\\\\\\\\\\\\/LXQeIUSC1OCv50+NBisAPKj3AEO+6OcPtuyHJ3ILQxl\\\\\\\\\\\\\\\/5Yw3h8HbprWvkguH1x+whAAhTnobleZB1PXGbyI25LuppeRbZ5bbtF7OdP1zBAlPFRMMFfeunHCFaGd4T8y4pUwb+ApSocOeTMatD4Zqeg2wiJJnRInRHCd4g4h0cT7RoFhk4BrdoYgANNwAz+obBBrGoGyuJaLH5GSLUL3T5rvxoHZJgWza8YD9kYOmtQ0k09gvqQOfbW5VuQH9V\\\\\\\\\\\\\\\/maUGmKxaE8pupCI\\\\\\\\\\\\\\\/LfpZNFygliRp0cgZqhkh8CMfQt1tufRQLHAnvkrDUIQqrRWfIaFpnTb5A3KrequU1hgQfMITpxiSKCP8YBtcE8gt9qbrKD5yD+4vUnDwCSrYGBsQ5mb5cKKWd9blLFKp0oypcoFd9U0QLk+uTjfPNLVtbcsqfemetSdtXQ+zheY7hGf30\\\\\\\\\\\\\\\/w1P40roA8VCQCu8+J\\\\\\\\\\\\\\\/vrm8KqFJ6x6QQXGoroYaqZbkg7CZodm+h\\\\\\\\\\\\\\\/dE2TRpSa6Jqb26Svlq+OcwmBog2kcTqm9p6HRX+f0FuvpDMdHKylwo+n6TEyav84cXCtsfm9q33dhGQyhuR6hY1so\\\\\\\\\\\\\\\/nudSerOU8Rcd3aFNJ6TKV\\\\\\\\\\\\\\\/Jc7QyEbiRuHAoMheED0yHsaJe+SRqHtOM3ccdXjoSi\\\\\\\\\\\\\\\/+7Wc6NAUkBriBauUaUe5zAWamqpZdH5yEVBt7iiS1CUgdKWsJRxRiVpwF2tTBMbygY\\\\\\\\\\\\\\\/i8Sp9k2CnxxeNGZhxuQF726bKuvX\\\\\\\\\\\\\\\/MvFi3yXYf2JXfqf6kRzsSuk9p6ueY6pbuDJBVzwDcX5rdx8uHg5XcMVmuX4I+o\\\\\\\\\\\\\\\/dfzTIAD11N+wXvGfmcoveA76JAsQQDb2R6OYC8yOzzXzMlZitpu9W1YsK3nN4jynh65rulI8OW8Ej5n8yNx5uZXnc5Gcs0IEDEYlROg8FhgOA2PU7CFksPX\\\\\\\\\\\\\\\/1UkrCsq0k5A8ZK0r91WvDR4SZoWR3s15Pu8Wannauy+uhjYVtJ8GY9EhZXzIC8TDN\\\\\\\\\\\\\\\/o\\\\\\\\\\\\\\\/V0RP\\\\\\\\\\\\\\\/Yf9TxNas1+7fALBZKP2y3W1FR9BIKeEE1XJYqMkAsyvV0cg+vz8PZ2uJoKUG+NS8tvonVGE1wg5eChTrcLvBzaqJX8mHbGd5D0WzFFgaaG9Ykzwc21UFq1yE+BNfCDYsRR0Oq+BtGITA+ZNRVYR8d33x6vdNPvHl9rh3SrIBeOBrrGf13UE5QMh5YCWZlBlluZ5RolDSvopZE298LGit5aBJ39X79sKxVKf2IXTPtshligDxi7aVuOpowlXeGsV1lpVIuww9eJsmVJPHF3MpmxsX78jK2W6\\\\\\\\\\\\\\\/WSmNsq8edkhbnRbNnrzRrwG5Pnoz8vHMQ1ewtnypxDEsz917yMUNBobCqAskxWbY60Ed\\\\\\\\\\\\\\\/xH0iraI7VEV3y8sDVrP2klbu8xCeqFxVzO\\\\\\\\\\\\\\\/S+F0mhooj7ZW2UlMe82f8wUPc99djNDLg8rvchoPtLYiKhVz\\\\\\\\\\\\\\\/N4vZ+q8SLSMo+JUHhlx+wLpsCl3Jw5nzfvoFlvYAlaNJgGn9hgaOpVXONngqF7a42zYl9seRo5+vnvv+T82fDDouoHNzQ05jCg4IRqNgRTlGylij\\\\\\\\\\\\\\\/SHlWPRmrwRABiN2JyVjq8JR+KokEPxaeetGhnw0sSjZ0\\\\\\\\\\\\\\\/uUxhDKvsnJMwfqX6tZAOGNgvAYvIGh7QPEfSq2AWHpm7ehN2y53JQODqXTVZubTvx613TVl2FeqfyRqa68elcYFfmBFQENGJ9rXI2qSSHJQwF0nW0Qt9PgOD\\\\\\\\\\\\\\\/ogro6KFsLg9ErejvxPmrc4w8dUJaDx5+Idl+aVTRfF3lW\\\\\\\\\\\\\\\/+G1ujSXNvJNjEqKoX2A6CRCwfq9VWOeVKfDhV46ftD4LxlCOW8rWLz6g522I\\\\\\\\\\\\\\\/W6ltt65ey3JwGyL08qWBP7blIrMJ+56qZwK4Z4\\\\\\\\\\\\\\\/94PGue8WTPFaoVnl18DxNZqrHcVoDu32lAV4QVXMLc3h9h1LzdY86wT9C21uyAMr0JPfqSuHSjQ2OsyWEjkIUde5vPJaOWRx34k2BYC2vcIcW9\\\\\\\\\\\\\\\/sF225AvOBa1\\\\\\\\\\\\\\\/7oqJT3sUbHfJ3Ynfy9RZgAWYYtEXzFqW\\\\\\\\\\\\\\\/F\\\\\\\\\\\\\\\/bRqrtyiXL9v286HwhAeA9j0BhlXOEKwFBm6YQDg9deMzhsM2qNiIByOumfUj6Z9+cwIJwazimq0Mf0A9CdL5\\\\\\\\\\\\\\\/MFhAZJpP5srf\\\\\\\\\\\\\\\/S+sF8fz6G\\\\\\\\\\\\\\\/qOWL91SQdBCgjdVxEs2r5KMzn7ZSbJDMl7sLMT1dKh2qibjORZiTnmPjFNIqfnaEPYFbl1VeLPI9gOfIFqV4w=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022LaxONwqM4Z8qlNZLZfoO6A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fb7b1dc47043679f325513fabdaa5ad7363f358ba4c254998084489a39d866ed\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/3\\\/e008443.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/3\\\/e008443.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008443\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008443\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008443\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}