{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022zDLdTIXiLquVco7kHGUCKs\\\\\\\\\\\\\\\/fw+dj6k2s1yLQp41Gjy6RrbvumBgrSfaWwEb3P4H4OfcpSRrS9O9TO73ejHIsJbGW9Yfb237dNCzMYGcPCWgw+sHsa\\\\\\\\\\\\\\\/n5hY0ziqGb5y+gP0+SZwGISVRwrTcgENLPbEL3nSP76x0FKMg8cw5DHCePYpRKClN9qn5QdWgAMImQeQSnLh2oK+OzEdeyRpYIuTfjdXFFDInXjn+bICRWEFqTXmdFaB2DDOvCUh5MjDTjwbuAkEkXAQVqNQW\\\\\\\\\\\\\\\/CQq94jurMg88k0l6\\\\\\\\\\\\\\\/Muui94S674+OyKgAwukdWHjo222mW1ljYaj1PtN18qBPGTlth1YQZP9jCuwPHi3feWYw7hr6qElhWRFZSF9kaLhjT5NNz5w98PPEi19XhPRRVVMJFz\\\\\\\\\\\\\\\/DOw2cT3IpsE6ReEptrUUsBoubcs2ECaJR8DCxV85qUAwvU8S+lXluhUH2oBKApKIMPoiDclP8Dsd9lqjbU8V\\\\\\\\\\\\\\\/BN1HHJemV+AXdkFhJaNL8qLL4zhOzE88Uncm0\\\\\\\\\\\\\\\/Gz6szQhl+xiZcXReEehfFdtM+IYMvpo9EHhFXtVixeFoYKxLcgE+3\\\\\\\\\\\\\\\/18EGFeb5I6BUaTdOBQtOFvgJWGSkAICsXKNw9HQ\\\\\\\\\\\\\\\/vYKEZAuLP13LTqOqUaw\\\\\\\\\\\\\\\/mFDQpMPLJDWA2Wsbz3dtH\\\\\\\\\\\\\\\/fxk5zb3UsNKtiRU23Nn7qqmhQU5vXHOLX19zconQsU+S8JF01oM4p7aehFQPyNE7ZDraL2dsSWg\\\\\\\\\\\\\\\/21V8bpvNbUU720x2qomRlBmA07lYnGmalYXVVvqoPB7DKJYstsR\\\\\\\\\\\\\\\/THi9LLyEZtiMdurfzyuBdutR3UNt59oqw7X17OyztHDXNTsCGiqNxzm\\\\\\\\\\\\\\\/m7hrk9Cgn1y6NaNZIfh6HLVQVre+FoJtwHQsHRGHMZjAFWdza1o6kJGgCklBj+B6Yb29+tC1hevMBu4+1mLljxLAQkiy+zundvRCWsk+X7hfPF1i5nLkhE0CksCndQzFIzj0GAV2TMPGMQ9fWEi3ynkNTV\\\\\\\\\\\\\\\/NzezhkpFM5x5GaYA8soK\\\\\\\\\\\\\\\/1C20AqoSINrkZI2dWZenvNZEhWTvRAyF+c6ZxYpztySbZlOzh6t+hOcrFGhRg7sBFkhUMosHLodmUyfs\\\\\\\\\\\\\\\/BBZeGQSZQJv3bxYfTyRgXz3bmiCCQUYZfyMCGfL\\\\\\\\\\\\\\\/vj7MReebWh3CbfuPQ0UlKi6Bo\\\\\\\\\\\\\\\/xtl4QkFzDof2fSx13uj65B563BHNqI7NTxJHnUuLNzhKCewjmhjWdEUcrHj7lqGa3eXzx0WuySEODOQ\\\\\\\\\\\\\\\/t18PK1zKuvR78Wi5vDOo+HYF6Up55ErI34J7Vk+\\\\\\\\\\\\\\\/+zRY\\\\\\\\\\\\\\\/KDVjOKD+riNLWHMHwE0\\\\\\\\\\\\\\\/sFB9CeT+KufuouIaK0XenCrrtiOow5ELrliRDXPzhtudkBmWh9H8SxiMjmCsuQJ1bdAE9wjKG8uPOXo\\\\\\\\\\\\\\\/7Ab6DK7R+VGaPesM67rgFerOmCl37ViMB9Fq+AsTS\\\\\\\\\\\\\\\/wLPyCT9ihJNzcojziKCZ8jg\\\\\\\\\\\\\\\/7ljTpSGjlmzqBPCwhfJLSFHyDhhq3jPtxQGMfd9MiO5EfitdyzwJ+JA6OkBMnjSFF6Rhoo5iOvNGYsRtNp69nVRDkMf\\\\\\\\\\\\\\\/O4+EnKWY3t1ucoQnIOfF1mHizgF0ahDG0xlyqXIsqSf8\\\\\\\\\\\\\\\/W3R9D0hO75S5w1SczG1vKPac3vt43M0GB1iW0PxSXfeGUp2JxVcyduZF4jslwMx1er0fghXiGLHIljiIMzdEuMg\\\\\\\\\\\\\\\/LZ7xcluJH4jrpslwhITM0TkadUvwS7LmYRI7eCHCv\\\\\\\\\\\\\\\/HH8N6XXTqHY3jyda53DEblawumHge2Ull2TQmaG8G2w+XnQUfAAFvfSa+8LtiSHad7pqShuKZ4pd3lwcweWMj6uxfyPNcg1FgCYrUYfNOILv\\\\\\\\\\\\\\\/nQZSpXCK1Z2JZ5YfKNt4MKy6ZyE4s+xiekii1h1VngZKigTNyhIDp9ur5JEmQ\\\\\\\\\\\\\\\/feZizv6E85lTV7aiiKRCS5crMpgQgi0VDptmatPqYQL0PaqOSL8yiayQbL\\\\\\\\\\\\\\\/0FUMTTbRojAmGzqXvx6agsErlfzM4tZPQYRVn6NIlaB3CP35uOh0lxk8mvsOnN6PQGRM4BL0eXI388eUkBDtM6wUGL\\\\\\\\\\\\\\\/BrjaObPOh9wHVHPCQZEmGT4+gIvUc8PvPqQANLYCWKLwEZooou+kOkyphJX9L4yzwl7jKxXcRlu35Uzc1mB3puKwEgqGwrpuhIdzbxB9Acr35ab9ZdMDjcn1C75M1+04kjEOP3aLjp9Iz7XYLP\\\\\\\\\\\\\\\/m68U3OPBy08gz2QX4VMBdYHV30LLBEqdT9dDPQiAHxAtqsLvI3BxwLSebSo84Kh1vtAHzrKhFQFnW7WsqKM6NOnM\\\\\\\\\\\\\\\/zjL5KzktkLQx7egiEWxCUiZJ5pVhrLhKo5bn6rwV7CfxQtVN8kefJ0TC2lzkdhHZcPYegUm5na1P2v\\\\\\\\\\\\\\\/MSC7CQT\\\\\\\\\\\\\\\/+w5XH+YCeh4zk9t\\\\\\\\\\\\\\\/Z\\\\\\\\\\\\\\\/FKiKQo+at0KEu9a0qUa\\\\\\\\\\\\\\\/oPLt7rqrEPl5NV0efn05WuOkfJMGKcdXuMeyQPtq8nYQ1MZLkUKlvwUWcEXTHnTJ5djkUTNUuzvHygi6GJ4WUwG4qDGgnl+xfhiB3dQRJ1IAxCzZgQl7eGA+H5srjT9FcS0iB1X14FQF4qHRmfSTjYDx8h3W\\\\\\\\\\\\\\\/u8f60TdtCAT8nIB2tKgC\\\\\\\\\\\\\\\/iFtQHqL3hVJx5\\\\\\\\\\\\\\\/I=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022JqnvnsYAnOGvqwDL5uU8oQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227dc2966335ab60a5f68f1b8d4369fdeb6dbeeadf69b07fd9ff724bd26a203ac2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/3\\\/e008325.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/3\\\/e008325.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008325\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008325\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008325\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first\u0022\u003E\n\u003Cli class=\u0022last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}