{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022bwhbbsuOkWMqSHsZ6SzIeXhD2rR3\\\\\\\\\\\\\\\/9NL8VuDn+6axdMntdJ4LOXBhX74szemL0AZNFYj\\\\\\\\\\\\\\\/OdLzlg82AiamPdDKXDuJUIO3eC6gWasQMD2oQ7aEMqO1tIJhf54e5rPamexK8qhsFWz+loi9gt5Dxs0MUwfN7KFLnx9lM6yO5EWJXHU8k5CRoahtPrSARvjXzy0fk5R2yKdrYx1HyAtFZwKIbkhMkVwXknJZSkMr+PhvG0nQ3MZ7Dfyrc8ZCT3oXsGRTTnsAyWj7EXq0oYqjeKNlqPLQc2dGiQBfK7Pox63a2gdeGzd2E8nNCXyAT7ernq3iZIXmnS131tIbyd8huloENf5lrnCoKbqRLgqCdRDu9k+KREDcU8bVfMUOE+K3B8tL0NJKs4P4m\\\\\\\\\\\\\\\/wmJj8doaAEfdYSKJZNAJX7R+zbR8Y6xqGtiLtZbhIjAVglkgqdqD6OzfwD4UUf6vmPAn+KkG\\\\\\\\\\\\\\\/AZ2yNzrn\\\\\\\\\\\\\\\/5DMTcv+ovof+rB5YakSRUVQBdm5NBeaElDtA\\\\\\\\\\\\\\\/BqeLW2wyQjz+8CYfQ4qZ3FI0MN2hiC1pT1zav+ALG0nUNZUMb\\\\\\\\\\\\\\\/YBaYydAZ7KDAKWqyHoR\\\\\\\\\\\\\\\/SV3NF\\\\\\\\\\\\\\\/hs\\\\\\\\\\\\\\\/AiIwI38zBjmvrs4IoIRsJnxXu+JM0hNvGb38Q3wzULc1eDxwrJPY5DO83xqjx\\\\\\\\\\\\\\\/hGOjLdbv4vP+ea91Tt5n4VYKSA6NeJ7wzkFk\\\\\\\\\\\\\\\/8Ty+amkWZQ\\\\\\\\\\\\\\\/6O4zArQOfG6ELbgvOsNhxig+RW1coW63Wb32xUwiAbu3jo+EiUNpEIBN80vyUDotp6XBwPUl9UjFCYA+MC3cQLrdcZSGd0vevO9tcfG6woATbi4LXsYUsMW+8Koqb\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/ei5zf0xLED3y9C2lrIvN6HM4KnNg3fxzfnJcxPdOq7lYNPvN\\\\\\\\\\\\\\\/Nf7hYfDghPRFRLOUctbnbRpiaa98NQDFYsU4oRUwmTpMI310VUI5ZxrPS+E+GpptKaxkl+TsA5V8TgsdF\\\\\\\\\\\\\\\/kktLOQ9tKLx\\\\\\\\\\\\\\\/HyIlN\\\\\\\\\\\\\\\/C19j+gGUUWRbfahOlKkr+U8mEd+Af+1CvSv+89T+1rCxcNPLzyNTHAL8EruXByz0EGUmdeqXPLiSdk6IiCf1VkRrqT\\\\\\\\\\\\\\\/RtL7L5KvvVo8wEaVxy6lMfHgj5TB1HmPbIyeb4FlyYPA2zX+fW7tDFhp2WjK+jLe8UIgR\\\\\\\\\\\\\\\/X4LuWlb\\\\\\\\\\\\\\\/SnLvTtyk9IUhPRwVFQxdLKOSQrXOH5t7kGWNKvpDuAWJhZ2JJCVB8wAu\\\\\\\\\\\\\\\/VdE14PFKd58tMNeLUlh3JJwDL0Two3R4x4+zu\\\\\\\\\\\\\\\/+FGnKSr3K9JK7f0\\\\\\\\\\\\\\\/xJ+nHkaNfYUEYSqO\\\\\\\\\\\\\\\/jjQZaKp84vXD3jOYypDAO9t0AOOA\\\\\\\\\\\\\\\/xHeNryL7xHi3uumHW9UhAVpASZi6en5maT+aZvqG8sdhwlNpjyOHwh+87G+hG3AtllYKRxyp7IxPQRgVriF54SLV+Z2Whi7N7RUd5fBwfrPtjI4r1OrnM5ITvk2fSJkDhQa6IA3G6sGo+C4XJ5YI01jQIUNPnKQs+i31BTKsKtAl2\\\\\\\\\\\\\\\/0P7cHBJZyJgcaCf5JDDQqoGm22xzD09B5qFoohXKClxX04NFa0NrHIcI6fkY4N5i\\\\\\\\\\\\\\\/+R5+oFdc6JCp4ZQcgWAHRMvF6A+H\\\\\\\\\\\\\\\/66x81NE\\\\\\\\\\\\\\\/RbHYCzNVPCo8tzS4CBNMcvUS1UqVri6S7CkoyGer+9Ufv1QpGnSPRmMMekLs+oJyGhJ9QR4HRAzcAJ+9t7zDy5a+AuQeFahPix1TZ0SoBf36NPjbWcP2ny2y9s6FEAZlyO6hQTDAwaDW61GHELLdHz+PYrC2VkpG51tj0+K23xM7eM+i8E7e9OzX+Ee6CLI6Bn1jnmb3CwPrnxyOJeWacCwu6AqM3f4qepJzKKOv4Frgc3Eu8PgJQtJaAMXcxDK+FOslALaEyQYetf0TDnufdIUEqj6lqXjb5Q3MUMv2f1q6SN4rSXSRfADMfqEdtgScQXzAN\\\\\\\\\\\\\\\/9\\\\\\\\\\\\\\\/t1V4Nn7cwkfa7UfxLWu496vG1OErWHHshOBPZ0Cad\\\\\\\\\\\\\\\/1TYliOWioeqd1OGVgrH5+4XzYqDqzQCBA3XLLmT1tUvafA0EfXU6feMrewzvLDak60UqED3feyPQOtaioNNa9iFnHAxWHH075vu1xDsNdHMWikp45LHoKaGezylLgelOtRSkF6oGQxmSqMjGQJUwdOyDEthzmQwYn0vvX\\\\\\\\\\\\\\\/5uI1h7q7GzhAi9LOo6sS5mR+e1GpoZSmWi3IaWjy03scp2bwO74a+LlILeqUvmWx1kWo4pBQo6m5d2avgbEC7qaie2HJFF\\\\\\\\\\\\\\\/dJLoeaC+TCaZ\\\\\\\\\\\\\\\/2EetmKRghOz2XpV31lHYBylPovOd7CjC2ZZ0mKDxnRZfFvOLL26jmfcSfGdQuzKlRwafNcJGG+FndM5F3k2u6I4njMAUIm2MKdJHbOMQOUorPSkM1MP3VoULvHmO1\\\\\\\\\\\\\\\/gtg7AW4EOKPCipkGheoQB2MefZYIHPpmtvsFlNpdYoCnrtiC0lfHGEWSNsn1petyadPE8wdjHqjfJNQLXKURAZGAnquwDPFSTZKRuK11SfZ8um3SS99txb9LlPU5oW5Mx8NSUVFd0fT6zVZPcf1qUoVyKgCnNL8yA3++FT6fAhUcyjoOiAqhodjKVevIktjo0LbIbLg6wQitvE0c19G5SkwzBFZTySWDsg1aiJiFlXORiaykETUvizQS\\\\\\\\\\\\\\\/tYk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00220Azo3UkgwaQETvXOUugnnw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002226ddc9f0e5c3e266239e005301c3367f4163b790ee2bd587f1445eace3e7bc64\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/3\\\/e008254.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/3\\\/e008254.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008254\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008254\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008254\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}