{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022GU9Ajbva1VPpIaa7OvondZvAPvqOTVEBiZeSpCxgE4EWB5tLqrNvFVKDcoKpFctQzozssYxXHfgwLklhcK4oJ441rVPyhYPqwSGGbi14kB70sfUqaP2iBdjfaAn6TtQn5QeGNDiJkyrwca2fysYRfpA3\\\\\\\\\\\\\\\/LomDgG7yGq5IS8sf6MEZDrnsitPuQx4Fz\\\\\\\\\\\\\\\/s0WuhzUbs3OFNfyHfJTW2q\\\\\\\\\\\\\\\/90eHghdx03Q+lx0QnF85K\\\\\\\\\\\\\\\/6\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/cL\\\\\\\\\\\\\\\/UuL3aoWicCwtkys9+XA1VxlpGRAPCRrEmxT2UiuwUZuQTai2LV9Dw7afxmxSM6uOiPgbayJ6wMNknnSSjK6AsmTxYx9xacs6m8hqShHCOCOXPPOD35YtmB1CXFtlzcBwEOaE+JiN8C9JW2F8LgAByxGnjTGvJKg9Q20MlNOYIY7+V7mY9FLC7xC823klIgVTyFT\\\\\\\\\\\\\\\/MV\\\\\\\\\\\\\\\/tQnFEGqFfM7PUGj0J8L+Vpe6sAj3ix2AUfWOIg8Q+OCoLyom+UFOjaMju6GwHq8MDh8RrhxiiagNcB2MZkjQZf3p+xZt0rHnT1BTQKBJnTGDDGcnOt1AwmbT00Cpb28X6KcgGrU3L9Hf2z749kGGOyf7b6MFUthe5QkXaAwA3+DMEkTGMMjY15\\\\\\\\\\\\\\\/iH8c5plNWYIc8gKU60j0mLVykphApwDVOQI8e2cHixzcQom4iYwl8Jymf5NN5EdpspKrY0sgFQ8DdzCOk\\\\\\\\\\\\\\\/3gNLaE8Re+psmdnLckSRMPjO0ZKOEap6opfucKtOIFY01ZMzw\\\\\\\\\\\\\\\/oTOtmCowTxSBwK6UmwFg1RaW6UQRxn8SN3SEAxN9s5wQEA2GbLSMzyL2uuvLMySDiSvf2ip6Ly\\\\\\\\\\\\\\\/CPh+7r4pjHDviZXaK3JrlMs5+QiLzyR5MXCnV3dhG4Fu9buLCyeYh4z1YtURjXXm9y\\\\\\\\\\\\\\\/w2MycL4uPcmg3Aw\\\\\\\\\\\\\\\/K63I+PfbT8AevgIMC0SFiwCyfrEGFFJUld3P703R5OYgr0UwI8ydVei48SwdIzzChx2Kshms+tw2UzlRH5e24i2yCgiZma7pd+m70mSy8qHWYtVg6WNnDxhmLgq9q88wAem\\\\\\\\\\\\\\\/X3EFjdBl7i5Y\\\\\\\\\\\\\\\/sR6Xt4QvaJUKW05LmyxHANCCETJVyUWh5wu2lYmdX0KDwTDG\\\\\\\\\\\\\\\/pgVAcby2jRt0LDzB18G+cefyeVoB9zS0SDrPBnFSQhDNLYBqJNTQRMFKSuGd45HavgC0L8UwZPQVYXsEyLkWNMjedI34q5Qw1L9V4KibRtRVIxhWSfVc075O5HKuap\\\\\\\\\\\\\\\/cgr0dYGxOG1gIn2S8NWX6G4QVS3m\\\\\\\\\\\\\\\/jL5O8gSVo\\\\\\\\\\\\\\\/dQ3GTjeo\\\\\\\\\\\\\\\/kuCbh52S9iFnK6NQ1n8sePNmtS9N5Ua+JvCexWa4TmfFDLiOoHfXjAl17wjaQqGILFlj7Q7U74ac1+NFvKct\\\\\\\\\\\\\\\/kAoLO7DLJwaqEtBzlYFpxmx8tOyBaVnZtPPYUBzCoByUS8x8t10r4SrROOmHpPKoAkuwI1Krpb9rqit1zuJxZwAmumke36iM5dkjXoQyhC01Vhc+3QUe8iq79F1blyLj57P7Ww\\\\\\\\\\\\\\\/ABUhZm3B+hoMSBihgnDYfAzp2NdnQOXI2r8aHmmCUjDRp9QN1\\\\\\\\\\\\\\\/Ihl8\\\\\\\\\\\\\\\/2eRCaVDyXvQnYWyQmhx\\\\\\\\\\\\\\\/SjdypiS7af7cl0EjJSD2EfF2tIaguqBY4Iz3Ld27Sc8piFhbj+fONNoVjtKe\\\\\\\\\\\\\\\/v7Oh692ANFimhdeEMzJMNer\\\\\\\\\\\\\\\/Zxygdsy\\\\\\\\\\\\\\\/LwsYfFAzzZMTLdr1ix7knyjZY1++aA1T7yWZ0zt94HlVXx6f+oCkzkfe\\\\\\\\\\\\\\\/4NKzDGPaAWl4pmqWRaV8lHaHBJQyt7sQWdaUh51a4cPLGAPWmdMVuzjBHq7udVlM427bcnn4Ht1ZtzjeI5oVlcD5xYb8sf4aGzZqIC2ppNQsnZFOkDgYPw7DHGorBP1DAkdPUImmiymEe8yF8ruqJSW+iALaBQuqWA28fcF+m2TIHVT0dvMPnQIZ+wyD3d5fyAzsZpkGjIVfIW4jWoj\\\\\\\\\\\\\\\/IOTXQWgkAxRl+uWoNsXdNVZJOJVktgwVPxYKX0PVwk64cccaxS3XsvO8C0KO\\\\\\\\\\\\\\\/k8vCZ7mULVsGkI5PqouOYVg09NXg5S4AfpURwCeXwUSpSmD9SmSV6rbw\\\\\\\\\\\\\\\/T6TYSKGgTRbd0Sb832xwZ4T4mGlAHPpL5e5JjRkrUN6ByyJxyrCUQEuoA6NB3sMEfP5xnxk9BPOanri9lPGrYIpIq\\\\\\\\\\\\\\\/cczVc\\\\\\\\\\\\\\\/gUEsfBJ2WLYfLa2TRbS+Lhw0izIOqOfyaesr3P1\\\\\\\\\\\\\\\/vxku5sVRwA7owN8vYn+qJHYOH0xyKYo7bdmw6L7ivCl2RK1RcPvTvgRdwEpLvhmCjn2nw1i89EWHbXU3tEpnYDDmNRNMDfzr0PjWs5BWaCyceEubqBvB43ny2lEEBQvQ3suAjZgv8xXb3yqD6l1qYIY\\\\\\\\\\\\\\\/ZzqqrYh0yPDffrCwR2gG4cu15Wjelqa42RZ6WNq+wAMRBkkqFwKsQ8ChDgmyrn3hYELq3jcI4LPeYWLWrt9lHb2XFlpmSUFJPYa4WwoG7dxh46YShuOUT\\\\\\\\\\\\\\\/h\\\\\\\\\\\\\\\/QyBZGQ\\\\\\\\\\\\\\\/WduIDLzGuEy2FLPgMUtXpQKyLQqCMg0sljiYVWjJ1TaWQaMDsJ\\\\\\\\\\\\\\\/FI\\\\\\\\\\\\\\\/RF2R7Q5T2K+MkNct3ZlBZetLJVNLgSjrkciBoBvY9EMDLpNJVTNb5Sv\\\\\\\\\\\\\\\/LdNWo9o2xbH6T5IF\\\\\\\\\\\\\\\/poNxSsc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00220\\\\\\\\\\\\\\\/tmk04iZSbtXa56Z2rj1g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d4d5cb77a3d226713d2327f33da8edbe0043cec91e47c359e0ce2c48a47b16ef\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/3\\\/e008652.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/3\\\/e008652.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008652\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008652\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008652\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}