{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00220rfhXFxrQAJIuzgzRzCZeBFstScsQcn44+CGRhNS2X+nD\\\\\\\\\\\\\\\/eChh13VOpprM9vottYgPmaHxGH0xQGEgxlI56m\\\\\\\\\\\\\\\/wwFAogznMVpr65\\\\\\\\\\\\\\\/OBrDfmBank4OuokhSRNZGZBqvPRTVox09zQ+Jo6wxBOxe\\\\\\\\\\\\\\\/H7R4pnUihvSrwiGQtntZIZeHL5qbHN5Dtl9YEznbdoQm9Zh2jeBXxRUEk1G9iJfwYNuKZMmMsYwjhzhuGeGwvnLUxl8MWhizWB3H+xeDH+mamB6WqEZwz\\\\\\\\\\\\\\\/wOUs+nb0xudaOY06W0DqWN3w6sdMRXxkVFFaILjzyfL+kPg21Cm4XICJUGr7D7N+1jCHm4cXhxVyFaEVjmZ\\\\\\\\\\\\\\\/3\\\\\\\\\\\\\\\/Ke5QeIeuvCaoDKWooyHFIDTysKm7LQZIiK05QoHvEnbYn4VRyDnNNAE5G05vaQD90dNTl2k\\\\\\\\\\\\\\\/zk6pTFbsXcmq5Y6E26mK7jCI8nEixQMvVzQLp+oczIMBDu4uo\\\\\\\\\\\\\\\/Zn0ROTK17YYtt0mGJUQSYhZOQgLBwcI0CkPMCbrvqgw55jXFo1HvkB5NFK1CL1CBX6rDPWnRjUgEqrgiaOI+xaVMw3UnxKHQf6esyBeumh7IYGcfZF2JFwHUJBdzDc0\\\\\\\\\\\\\\\/ja2B0oWVDo4CwhCxXEUXH8ME3SjX2mYcXK\\\\\\\\\\\\\\\/b\\\\\\\\\\\\\\\/MjCkxNcOtsM+ZTCy1zQuWAs2wUKlxVRtMJoayrncI7TnMDrgkfixpfoOafl1LlnEDElUYyvEBQ7uV7TbyLF9MZoWgk+uspXwH4YQPbIxBcMPD5lcvt7b\\\\\\\\\\\\\\\/Tgk7JhEDZ4JH8GMJWIEsCLeJ+oy6NWfHBZbNfjoxheP2bOVKj4pY2QxMZoB7O1OaMbk7jhZGHbqASkrS2\\\\\\\\\\\\\\\/843hJh1lWaYF6\\\\\\\\\\\\\\\/xmNoPdvCdQxzljegrkgqSAYjbP1G53oy48zSnp\\\\\\\\\\\\\\\/JLt12FnDpLci0T\\\\\\\\\\\\\\\/ueb9uyVYF5AvRbld+Fufuh+1a25n6X0gVkdEmF34L2cXOw2JrOyyMBGbfysNIynqx9nk+0M8tTDARzyxTiPp7laQohZdpytL1cQTaLe4hGeShArPGKILdVDpvtAqxYvmHJPrCKcdrUaGuX4KQ38heHHYhsTNzhPtbnm\\\\\\\\\\\\\\\/BxwlvH6WIrvHFpnGC33uqTGAD9ofXDLANfIAqE8LNpWwFaYEudo\\\\\\\\\\\\\\\/pyjT7FMlrUzwcABegeZB9AqHMMYmmYqmaTNxDNC5BSDMwRmbBc97hEw\\\\\\\\\\\\\\\/w8QYjv0vssc\\\\\\\\\\\\\\\/2vael\\\\\\\\\\\\\\\/qNXNuKhz97Jqr03wlksmkiXGg7H1FhqUCgqwPKuKuniLfym2Tq3XY30dFrfMntPNdaMjnCHeRJgJ+qwGI7dC70ePORlMqIOyZlI17\\\\\\\\\\\\\\\/xVK9nKVTIlGOKZDdIFIv6r1nVVNDICWvysItcrwi+FTBjAX7wd\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/bFAE4Q+f\\\\\\\\\\\\\\\/r2oM3vZ0e6GZqInR5Zi\\\\\\\\\\\\\\\/BnsB+7Puc3tjc\\\\\\\\\\\\\\\/rZoBuZagNfGCwDgUkNf2SFdrUVWlomlKgAseuvlXZf9L3of34v\\\\\\\\\\\\\\\/jP1qwWN1w4YH2aT2IQNs6\\\\\\\\\\\\\\\/XyNccTlp6Tx8Jhqd\\\\\\\\\\\\\\\/HsdjnVFR+sWwgTyOdMEzr4Baqfi9+RIxNS+bk3oGSBw8FSma6QjzMzHFKAsdy52+RagggtXD2f04RnkQlENLDxTX\\\\\\\\\\\\\\\/z1HZtSd3aShJKk\\\\\\\\\\\\\\\/26uzkM6FwGTrf9HU1RHo1y6oRaJYZxzgvagO0\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/i17ouGtzFD0abhKbjp9XlQ20Fv6UoW3fGk+9akmtCZsXqA4OY\\\\\\\\\\\\\\\/xpY3W3IC5+VTV9guz0A2Zqc6BXwx4ElbVN1ZtqXJQkVB1EG+hiu2fl4vWP5roNSTAlLhLP73heKsvXwXvbwh+zD1bT7H3hL96rCR\\\\\\\\\\\\\\\/IyMNOyUV7Sh0e8yBVf+UzkzDaz3SIyzqrCWeiOaxiBY+BLTPY\\\\\\\\\\\\\\\/ZyqrA6sHo1b5qF5oDk6kdD3ax4nJW3IDjjTc5NqMP0cpbm9xnKkCzXKnbtICfJdXD6+eFRZblxUy4YHDT0aanvKSF81vRTqcswUsyuXEOoR0UC4vwYkut5SKzEaLMSNbUlq8zyaGm8Jlt+3EVok6kgdbaMAou3oqe7KdG4Ck+vwavqBBOq8Jto5DgYkeahJkFu2itqojqeS6qbmYvLyHDBOAcuvGG9qKXr7DPMMYVsuugE21NIS3lMcZ79FsdRavADuEvIEk61DBOPc9rwynoUYWbhufcta6Wm5ymx7O2VW1rjfPydRg2WqYL6Rg8pJYW6YXKz9p8sRdhKHUhC\\\\\\\\\\\\\\\/c0FwiXp\\\\\\\\\\\\\\\/VFzY8n51sj1x2L4Np0dK32iidpkpj2uEF1yIBIWjmx8rnajRp6vGavAuhqtrmtX47NhMfO3w9mM+EleiX6JO7Nu6drdJ+zYtLST0C27Cqm0fgk8VUY53QPXadaFYp9XPl+Zo\\\\\\\\\\\\\\\/se2qgkyCx24OTMyT\\\\\\\\\\\\\\\/3MDmO3OO9O9lOJurHLFvTWK+bMpGa9u\\\\\\\\\\\\\\\/xYdrwbxkpqkdmEv5+uh5c0Zru5zwuwLQsEVUiY\\\\\\\\\\\\\\\/mNFjwfdFq5htvaGD74auCOy1CIOcRocCOS23AQminNtk\\\\\\\\\\\\\\\/jlhzLSmrJUbvqAJoiVU4uN1\\\\\\\\\\\\\\\/5ct7MN\\\\\\\\\\\\\\\/ozvXNGV15dJZwULX1Ymc\\\\\\\\\\\\\\\/ipfec2jH6OX3aEgNCeRWG\\\\\\\\\\\\\\\/SBVczEOELXC5w9Z75gzt2Jzaum+fiGp0Bb622DIAWMYdpvO8d5BPHFjIjee5mI\\\\\\\\\\\\\\\/36Qh+w5hm2BLN5d0XsYfUSZ5d1ZY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022kOL+C0Sbs05yQa220A\\\\\\\\\\\\\\\/viQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002275a307a2de4e40e7571a2c4aaaef588f211f23b2c95df48dbf124073920ab126\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/3\\\/e008054.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/3\\\/e008054.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008054\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008054\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008054\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}