{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u002237tTGNgQr31UeXpMY3Q7IWeXfEqS\\\\\\\\\\\\\\\/Z75mvTBVfZNOEeU2OjYhIYX\\\\\\\\\\\\\\\/f8h9FUSs1m\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Dp6hepS42Mh6e5dBKEwV+29eELCBtbd7UQ3juOcezd1Xm3B2x4EMP8LPgWzikmp9HWrb6OiZk\\\\\\\\\\\\\\\/PO+3fUTQiIXRaFiWhh3FZE\\\\\\\\\\\\\\\/JzWOldONae8WcJXhCJn604TehpfLbzXd3zVrgf9pimTWPPnbM1UFdntiZPpKldGeUzYb0DOma6SJgIAi8Dd95g2vZZ5m4DqoJpekITDFGWVWs66xZECQs7H6ARdvTUb3PGLUaekHBYu5lLz2pqcGuQ4bQMlYG1NImrgKGsKZKcE8uON+hJiUamvRlNs4Pv81KtHMPoOCfczoJnsrzBis2HhWRogZDbmfpBVILKEhZZzoSfRIGF3ssT8Gkm\\\\\\\\\\\\\\\/SH8ku8R9byVmw4fHNA+o3MteVcXzyGkF9HH4jYxRJYOO5iLaA\\\\\\\\\\\\\\\/NF2mylQYhx4KOzvU2QaMDOz+VcYkO4zGEuzQ0snjEk0T3Vvh2iwCUHUkZQj34Q73XgifD95jD6ko4yqw0RJHzC24KiAWVLrH0g7OTPn1CXxCHsvkW414egIMcR5da6ZVLKKmdiZT5TIcXIa64ocDRY6r1hZDYXxyp+YHhtTToQNec+RVsg\\\\\\\\\\\\\\\/JtX5tqI4e3L33722nreWu7lQMYk8rJBxR3VNoxGLzId83q+EOPeIPF0B4yZUaK0DtgZAyyb0pM\\\\\\\\\\\\\\\/ZB7dTFM4eRqxG7mYB\\\\\\\\\\\\\\\/csDLqpecLUQkPQ5osL52o+dLcWdFCm46h5onQcm7GegkFLTmU4cfJiMNEARFEpuPwDs5ywIW6fP79d\\\\\\\\\\\\\\\/TihqBQK1kj+VKiWrgtgPR4tZkWqdTRwoZh30rpz7x68FGb4Ui\\\\\\\\\\\\\\\/KZvIkSrwCxzjAh\\\\\\\\\\\\\\\/gjUxwdgX4p42mERmXLM\\\\\\\\\\\\\\\/CyOkyhL6JSMBjsfqvTlrTukFjT5+OQ9yntk88Pr1h9\\\\\\\\\\\\\\\/UUyDp8h1SCHwit1rYQ0oSONE6UMvO1B0QqaHkKjZPmZnQG7sRnA1pzpUNHmnDqUfSIIZ9e+RgODhZLIrtyj9akNOjXP7SkqL0j48rihyn+kqlIBxDCYNXs2SCL7FhAToCMc2noSMp5XLN7F1lKKraqqCtXMsDNkhgHVav0nI4XYirX3eVw6ccU3XIG+n8LXwVobgXEAH7qd3iFNEwp9vWohfcOiTe9mi9L8rxnpz4QZu4eXPrI\\\\\\\\\\\\\\\/jnKvMkymsR3VciAQuoRi1dWpYhB0c8IJZbDeNZ9CKUpHCcjIGu+tmqZo9YrkAJMi1yHqJJprtJ1GvGeiMs1LYceYlsUdpet7vBFn\\\\\\\\\\\\\\\/aN814VAd7e7c7AzCcE33sDvgsOeTQtGG8j5CVcsuJLGP+3WwQgTSL4PeXVRLxyfG2U5nDV84QuLM3U4xXqWq\\\\\\\\\\\\\\\/XjB2cGiu2hx0U5jNS6UbQrvbO43pxJF7yLrsVt92CGQdvnQ+cMdZCmw927KsqS1CIvAdAz2rlqxVLCompeFfBO+y1zvOkxErbyZzH5xUMDJhbK2yK9Ih7niUGwaqEL1o83Cvyh4nl1y6\\\\\\\\\\\\\\\/B9nIMHtV9L6nOFCwMLXM4j2eumwROLod3ePPh3lN8Rvpj71G1OFICpO\\\\\\\\\\\\\\\/7pq2h8seXzYJmqlBqVXJouWeiPZudd4xn87OnhQicq9CMO9xx3UTvej7Ti\\\\\\\\\\\\\\\/H1ApQBwLP+I8SoAtSQX8vMerde8p5BLFDsHnE2BceA3ig4SsosbbWPBrNv46OIEZs0aX75Sswis6uUgbQdWlwd6TXRT2NfpNxmpXJ2BMp0zVQ\\\\\\\\\\\\\\\/rQtcEYBDFXoCwidFrnPYrWv\\\\\\\\\\\\\\\/2UrepejONy7hPCJhYNMqHSQ8eNT5BXcu4PiWE3HG0Yt91dOxqr747tfIZwaeSymfTGA428sk5Wdo6OoTXXdpRUtOGmR3J2n5HZnsfn9JTYu5snW8zgGbJ5gvyzVOTwmmVgG2PmUgmotYzf54YjPlm2\\\\\\\\\\\\\\\/4uZ1jIqx1\\\\\\\\\\\\\\\/PuNIv5idHSmz933+IxIzb+El1Mr2EbOM558+Z\\\\\\\\\\\\\\\/NRL0xFolA9GTrT2QA5FSjxq0nv35+ZtUAuFj7y80v2NU9\\\\\\\\\\\\\\\/Qw7amxAB8UcPsb\\\\\\\\\\\\\\\/ovX+t0qPZDfLWXKGYTjZCm4XrGCAzjvujod+xqUECklg8KLCWPYpPScDRZhpqpY\\\\\\\\\\\\\\\/hsePhQS0VnGsEbXp\\\\\\\\\\\\\\\/77oJJxsVBLJS\\\\\\\\\\\\\\\/a1226Hsow+sqtAhz8R\\\\\\\\\\\\\\\/mh8Pc84gsTGbyRBZYj83N\\\\\\\\\\\\\\\/dWn1wz25koAqZJoB7rn5jSukrz\\\\\\\\\\\\\\\/bFdnfui1jW7JoRM3M1BKF6A2Vm9OfPo98ycRP2zrX5YMWrk1qWIC4ILHq77NthSbXjL+0pRgpR7WIMddM8WoqEtLohgHm2dP4R090zi6DoZoWh\\\\\\\\\\\\\\\/UwtLY94ZjDjsDZ5IWMjHPZEdxbdSIi6Ltq0OnzOQ6r9ZhEhUjfHL43o9K0KM2w5Lw8j3qGzip6SwEthaiURXFK85KQO3Uv1CLJ0B+BKkASREivW5zXjvZtRohY0\\\\\\\\\\\\\\\/XTecc1tS6G8UYhNdMoe\\\\\\\\\\\\\\\/AoKLMVpvvT57okrSO74WfkGsUd7TDlPt5fHB\\\\\\\\\\\\\\\/YacpFAVUxvyn3VHFCqVPy7yC9OKs2VjTa+26E3xDpFSHDV0fASFYmgEvza\\\\\\\\\\\\\\\/DDXmlmWuhLRderBIqHegIj+ZdVoc+mIHZ6K1x87hEtyx78qbIOxBzqjrM4FSY3uErh6Og=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022XzLXBMd2bEODKwamdXjuxg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022195172ac6ef77daf883de10ab6713f1fc1d83db0fe15c2496323a1ffed186228\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/2\\\/e008735.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/2\\\/e008735.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008735\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008735\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008735\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}