{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022FvRXKuMWSlOvBLvzc6tR2gLPomtS5Y1QrF7DFlZ6Z60LlMdUJ4UbuZ6TLAaxorGZl0KuRm+vnJgXLWrVKz+FDYrG+qTb23+fA4HJCQjEI48OTBGTWs+zHCt3tDCkqNx2xZF4Mha3ueJWTogN\\\\\\\\\\\\\\\/LkzUXyc5NIcQrMjiEscsH0k490eo6vHATRm0lU0ic1bnVVZK5rr9K6\\\\\\\\\\\\\\\/VqL1blKkdlvANZ5dKE+FUnozM6XPDofi0vSdoDuX9Uipnh\\\\\\\\\\\\\\\/Ftpx0TaRugSW8NzaGRvy\\\\\\\\\\\\\\\/QkIqInKIEhnSlhV9bJBzQIJwxDovYMqNWVj0U4MCCJblFA2Ki+VJZC0DeqwpZ7tYzOTNkdJOlNh9eooridvamrZUg3x6Ckp\\\\\\\\\\\\\\\/6\\\\\\\\\\\\\\\/EsO4yq2\\\\\\\\\\\\\\\/m2yTuuUu6uUHpnpgygoTMBv51oYTmnkk+xmg9MK\\\\\\\\\\\\\\\/nbirFCqoKQWN3Y\\\\\\\\\\\\\\\/u7OhgJhPTv2mS1+Oe9KU2oghEUFoMPjiK+acvcWD9ZRdsUKy6YYq4dy4IGRWWGB6H9x5JMDs9AK5ih+zLrP5871sroQsXb5PT7M8ccnNVKatiP66SfxxjFcP3DSrKd42wBEMYBZmmJvpUSrB1mo3AlUoLmf3RMxLE3n5np46lONlYDBDpS+49kznQTk6qIUUjliGRCxJzIh+Yc2xwpAZzi8PR+C\\\\\\\\\\\\\\\/B9LAcLxKdCIbEY49Gz2LmZn+XzsKrOdy7l0THaWIavxrMLJzC4ckjDcE2zJXJjuIkyXVGvUybAZ8qdDtt\\\\\\\\\\\\\\\/LuXTUY+jnV12LbIqGTju43qAaxYz0hQWZromkG7NrzxhmaFYYYvjneI1dkKlaw42EjEAXGF2eoaJok8\\\\\\\\\\\\\\\/SzhOP7Fppprfc5xbnSjSwZk1IFzmNew28aKgl9iCP44ExREwczstgXdUyZfB\\\\\\\\\\\\\\\/huqQ44U7rORgaPONUIYoNe\\\\\\\\\\\\\\\/0fhQODx\\\\\\\\\\\\\\\/iDPQezJwE2hU8day5eTh8U6NUrsHaOON3vFeHor34KK7igZSR3rUGCY9b7IreuwagJeMhOww7Ju4aBNZjkJn1W9DUk4nzGsH5a\\\\\\\\\\\\\\\/x8A3\\\\\\\\\\\\\\\/vKGAW2grKRkouU4hpRbunvGZZaFixnpIgFpmdjBAjcMccqh+yjki6CvS3YWUJBNwSBEr2BuSzyg6eZT2DWGZJA3p074ou9Vg2q2uxQ\\\\\\\\\\\\\\\/TvOIJvSKB5xZUCDM7pLZgc499qCHFVEGXvchyQGiov0sS0uCFSF6vjg6GWdFkx5lvN1G3DQQf7Vbo54BPOtcl589Ctv7DYxLzUAvfFZatVG\\\\\\\\\\\\\\\/h26sd1YT6sjqiBD2UCbtXAz+w2jRdiPnLskptG0b8ljdVHUm2235k+LzHz1c7pyud9W9Na2gKy+1J7IgVGc\\\\\\\\\\\\\\\/0sMYSPKJqxls58FfNQJ37ZXlw4Ib0IlF7dhqUk0IxmAFODyaCy4nX+1+bWy5IgA4OJhocOMxbG8Io\\\\\\\\\\\\\\\/+kWbQXdQ5B2j8FVCGMEmzEj\\\\\\\\\\\\\\\/ZchAX8p7UUlgkd1de5Grg0fqsF\\\\\\\\\\\\\\\/q8g+xj+oTOxYustQmBEXga5sh7\\\\\\\\\\\\\\\/WAg\\\\\\\\\\\\\\\/33asl\\\\\\\\\\\\\\\/UNEYy9w0szqxrOxIvx2KPGqMVDHP5lP1nN7+ZM3Yo2k6kMnD6PdzNWbiu2G4MZh7XsMhnRObd4j3iN\\\\\\\\\\\\\\\/EQeHqe3GnDrgIr9W1tBrylIiAj+76wkB2d2H7kVtoMDuReN0ivjpeJqiMHM0irtFPHBP0av7ywTVhTA1WN1Wn67IUeV6d10YL7Rl\\\\\\\\\\\\\\\/7aItIq8tXp9EjkUtDPw6rRpxOjpOpJZDRLo\\\\\\\\\\\\\\\/RABtcMAVM6LwAFcwX2nlOHmKhPv5ppfViFRvdstPDd+m4fNT7JFLn9Ic0Krp6hwyzrpzaPIEJsjv4awdp5eTAaEToImJh5CjLjZb2cZsL9iZMrqbQITfLHAYVZ08Q1zJ4OG050akqVeM3hfaa7vzpmwsivBVrb4Si88OAaYwwql4AxyaiIekno1\\\\\\\\\\\\\\\/PVBvQbXGuRzakB\\\\\\\\\\\\\\\/pA39NvT2ogHSAIv5U0SLGhbQhcRMFgjdTR5UzxEvOHVmIbmOINXFUOnZqOpEsKKQDphXxojObk0xDxdqXvQTuegVatMclaVUtGBbT9WnGc6sv3TgWcUdUi2\\\\\\\\\\\\\\\/mbi2J9U0E+kfzcUMgL\\\\\\\\\\\\\\\/FWgkn\\\\\\\\\\\\\\\/9FsiQWkM3h\\\\\\\\\\\\\\\/kWvQSQ60\\\\\\\\\\\\\\\/BLoRDkzCULeoDzWW7CgeigGDDnKhhSv0KUgAx4qxbSN5Sa5p0Pxbsy5Kgpkvdr\\\\\\\\\\\\\\\/gc59iTG4u5fvfT7oSrV\\\\\\\\\\\\\\\/chFU9E3A9a5tgq7WV4Q8q7irXr2ugPsNnJ2rOaCartVtP681mc2O\\\\\\\\\\\\\\\/k1K78z+HGIs7jy+uHJ24qTzmdRbu22+l3tH9OG\\\\\\\\\\\\\\\/gx\\\\\\\\\\\\\\\/IHanNYEy2ydRRu\\\\\\\\\\\\\\\/4kQq8RuKRkP1YuQrmKZW8WUYgOeqJbB90ZwDltRCjksfSavizINMqZxA9rlmmgJfEAWSJaBD2Sydvxatjb6cThTHvvZM8Z6hAFLGJyahDlsbFN5rFq8Nu+5tz\\\\\\\\\\\\\\\/32tVPFHC8kbyNtUfCFD+eub09G0jSbcBgqe116O9HAYMDO2\\\\\\\\\\\\\\\/6TpFev8C1NRkeuK+MSdMaiL7hUyYWQcRv75\\\\\\\\\\\\\\\/y97bBKCpNDpxcqyBaKNj9RZuaLL5k0Rlozb2U2Wl7j633G\\\\\\\\\\\\\\\/pN1JEjjzV4VFYpTc0i4ekOG1EReH7qn3iu04QpG4A2IP4YobrdAz5tV+vAUXVWeAOL2B1f9WnrT5wSyAjL0VwvYQZ78qtujj7wCJLMdpdHWtk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022AGQ2Xy4p6AfpoyaQEjPYqA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002213228018527be2987b8b64e726cd1098a3fb96fd00e17554b4725f80316c01a8\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/2\\\/e007981.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/2\\\/e007981.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007981\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007981\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007981\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}