{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022iDJy8wFx8ftGK+yPXsdSufp33BH5wWyiKfp1p3dDqMN7CNGQuVuBom\\\\\\\\\\\\\\\/wSxVh1TA\\\\\\\\\\\\\\\/g8J0ZQcJzJuusFJofjsjsr7mNANFcnDtdPdcrRoMtFVGKXZNDg3htjsdwNYfqN+o+WRdJN+eoTmtZLGmBhfyVp0SjCzZCPqgfWQ1Z0j368tkX3giToUX7bsFQCorUkH4FzVOYvVZvy7vOVvZloTZHZjkaI6BQyYyzhNjVdnlbCyZBsgcwVK49M\\\\\\\\\\\\\\\/5pSkwYJlmnSNcCCUDpdcAKjj+wC1h6aPPjlgjCMWx4+w2U7s3fVxNvQNu7sjPKTGMhKv8JbDNr9+JJxJ3CEiLEPdgIlivwCkgqonZpVV1l9PwEHruMbMKSTiHHPts\\\\\\\\\\\\\\\/coe9qqxuZE1W5GNOmXABK2wBCxVyNksvAxV\\\\\\\\\\\\\\\/vF\\\\\\\\\\\\\\\/qrOnR7TAmn7yYMtU+9LLMpp5rNjd2KIWE9rJXF4mG8P2GpZbTbIKfSPSS\\\\\\\\\\\\\\\/toIl5f\\\\\\\\\\\\\\\/CS\\\\\\\\\\\\\\\/FDQyQjOiJlWZCgmobX\\\\\\\\\\\\\\\/zKZP8MAKF95V2IsIvYRfeALtMAQ+lGzmmwK8SpGVXc9yeLShxoCWglT\\\\\\\\\\\\\\\/TxxC24C8Kwq4O7m1PybkjjyrMbbUw2oLbymTJjKeG5ObcFOF6MvS4hqdBD1CeAb3R4XzybwMKP1NaKuj3OIaa9gFByGPl\\\\\\\\\\\\\\\/Md13k5fSALM17vV0vvq4nY8wPlDAUAhRmww0usP8CalkTDTG9t6fZph\\\\\\\\\\\\\\\/MUlzDMT\\\\\\\\\\\\\\\/hRCMc4bFCeD0B7p3+L8BTLd1yl8IBjwP7XFUajOFdufFXF7igEB1n+TZkhhsy9EHeQuVQ0612C1fHvK3w8QTf5t4HKME5ihtDrd6QsO\\\\\\\\\\\\\\\/N6x82q06kR1e\\\\\\\\\\\\\\\/yYfvx\\\\\\\\\\\\\\\/GSnJY1jAkcgsaGAtub+plXWtT\\\\\\\\\\\\\\\/2paUjeU1MCGh2XrSQnsGzuaznlxxX7fRy2d+xUEop23M0\\\\\\\\\\\\\\\/2qM6B6TimvH9+6L2s9J1+hyG6QFkDrZH+1iBjMuCokFNKCTsnLNg48proa2jptNPSrUqC8984ddUmsxTlmVeDoUZYDZwYmvw28jXmI6qwvfblVaq5fby4Jo1Lgs5FCfw3sjTMwNZ\\\\\\\\\\\\\\\/vbnHEojiPumvET14Yb0CT06JgQ5Pp5kuRSdrlGZJBG8aJBdZ7G+hca2Z8xmEqwn1SZ52Xe4khCt6sf8ib6sCGF0elhnticjQirq5AASuXKBVgeFWlkfgxFFm3oDCDv\\\\\\\\\\\\\\\/hy9rfZBsHDdPVY3+q\\\\\\\\\\\\\\\/IQ\\\\\\\\\\\\\\\/ZMUdrlcDW\\\\\\\\\\\\\\\/al2\\\\\\\\\\\\\\\/Wl5123dH50wCZOql1TLUvZnYNdaXBz64WzjBNBYg10eMx\\\\\\\\\\\\\\\/F\\\\\\\\\\\\\\\/hLDAU6cZK5clAb53wV\\\\\\\\\\\\\\\/ATyoxga4KwK3wtyOXP9YRVGAU9OpdpOnTZRMK7CWxxLPGfD6GzDu4Z6K++RiIshXAfg6lYpz7+olP5ajTqPrgfwnhNJSu0PVXJAmwcO6NByvJHzeS9Sqa0jCNG56X9rN8DVd8UXrb1FxEPrjVGhPCuFzIDs0LdG6otQk6DbnlIskVIJGuRfwYcqd3h5AfQTiEJnsPpBxE3yKQvMCmszExgn6N\\\\\\\\\\\\\\\/DWGGgx3XVRu\\\\\\\\\\\\\\\/+aPgGAlD61MO8eGOFCUq2eBf+Yy9WY\\\\\\\\\\\\\\\/1CfZJfNRpKI6xSwT7o67DmHkBA2cVTzRxYKSTolS\\\\\\\\\\\\\\\/UhAzrmlaWunwnDYAa\\\\\\\\\\\\\\\/vm9dZVHZTwAFTzsv4nVzosRUcsRoBdF\\\\\\\\\\\\\\\/3W2Og4M1R71vAaIOcQQNQiQAL7SNWXthWe1qOaSA\\\\\\\\\\\\\\\/nVJxNOu8pyuFXoI6aMUk4hfj2z1NnCYysvKDtY\\\\\\\\\\\\\\\/Hx0Ed4rbJFgarqM4lbVUkNIxPIBgVkDVlzvDZUlqcJcbzr61yIPqpKC5ThLb7Ztr8DoXmVQcZ4uaw2811Yq\\\\\\\\\\\\\\\/6NEeAwD\\\\\\\\\\\\\\\/A1TVycvQssoxMCXiYq8hhEZKicEMbMPYdPYE59DlTqOmcNjF8aSmCbYd55hH+WMTIZ8ztvsequWfnPb+cDk0YvsvO19GwWhSdyLvWZMbO9LDgkbgNgPVzgVNzK6Nmy7UJ9QV\\\\\\\\\\\\\\\/fHbufpggQHHQbCT4WRovqbiCBCuVeYQbJu6+0IEz+QTjtFdAs04eXS5lVjohdzvp3ef00UiBvrIX1r2yyLNMpmYXj5bO4eAydFGo8WmeEcF1ez5BrrShkx53eMyB5Y2h9IqufQw4EdhqbaS95wQgDy+QLcJNaAM3LOMb4BrbfxJgp8LBMAEHuZuzeQesSd6c9h+a4psGZgX\\\\\\\\\\\\\\\/dWWolFMTJg8+5F8KtugtnSeI0btEXt9kXjk1j0p8moRNVYz7CMPR7o3JF0Sqj6zKeExCNK0X9\\\\\\\\\\\\\\\/mAwPFPes5nvTVoyQC5XYH+jWp1TZ6wBxRSVAqSCzEaHeYyfm+VOT9LYtYAdXwJ5clGotRUlJ9sWQVVKH1SNHLr6XdpyvW2Mi8y7MQPK2ElepuCNqFtdaTfA8meL84Jk+HVQ5VS+imV+1pvivOz1RRwTu\\\\\\\\\\\\\\\/PNMMFLkUzJ0t2pJ0x40aL514j2H4voAlPH5HaHjSxFnNmO0fICQDwBzwkQqH4va6Vm+BgrAbHpmDUZWwaPksdjmMwy21j3djFFv\\\\\\\\\\\\\\\/UA4bF2H65K5Dz0Z7Xwz4cPd6avqLTpl0G6w4lAr+\\\\\\\\\\\\\\\/t3tD\\\\\\\\\\\\\\\/p8znPThi2j1BkCnHosZVOt5iJuYl\\\\\\\\\\\\\\\/8kFz+uG+gxB9cHySfAP1gu1B10svn8kLl550ipg4yoIKq\\\\\\\\\\\\\\\/k978JTh4xNhJiCeCvvQw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022xjHpw5BQ107fLV0gDcMq0Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022154ab418c609212782a39a83955252136615dcf0514c31844300d050a9887433\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/2\\\/e008518.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/2\\\/e008518.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008518\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008518\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008518\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}