{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022MyhymYwv\\\\\\\\\\\\\\\/Svrr3q0pV0+Aj+o7xIOo0KcNDRXZU0HJ5b6Cv\\\\\\\\\\\\\\\/vKmdjckM1OsIDo5ust0aPJx\\\\\\\\\\\\\\\/2B49mxNutwkimO+4goKdoR6PEhUGnR+vgXhbaW3RaeJhmmIocw8vZcwmvKQyNeBYt4caQy0SRaAGigYRmAN4zskdcCi5rbIDXXJbrW0\\\\\\\\\\\\\\\/LL9OAKhbkxbubJ4dlKwXWDKvNBw0w\\\\\\\\\\\\\\\/TwxQLbGbTIOBwvzoj1sNtbwQsLlrtJCusiFUvdzQNECJoovGFmN8ddO92RJhjTl6X52QWuXoKKWHU4TXv7iXWQaHGof0GMoBI5qwFi3oM\\\\\\\\\\\\\\\/6Ii55lcDAT9oq1DC1tqO\\\\\\\\\\\\\\\/DZkjzxlYfxpuCj+Na7aE6hrZ\\\\\\\\\\\\\\\/o7JuZyj4zUu3Lik2Kul8gq9HG\\\\\\\\\\\\\\\/Fp\\\\\\\\\\\\\\\/rV022OYmzpPD4HvqEdu0528fUsMEqaYS1mi4LV0DqG61+5MQwcX8fkuL0wLbXlPAMGaIw3kuxTJPgzf0kpP+P4JVs9uamwVwPJAJCR\\\\\\\\\\\\\\\/hn90xBSWH+Yxy+pk07D2VE1+XkrQo+8J2mxNHqCHL\\\\\\\\\\\\\\\/jG0ca4LbBNe8x6KyFKILiP+Ty2ZAMGp4h6pW6fnLOwkkcICgi3a1Y5qSIq9YuYmdTHYGWnwL06ai2Q4bQkthHBAkKjDgYSpFxCN82vXKay3YEKwkuPKDQ90GNWjASaWMzpQLjQ\\\\\\\\\\\\\\\/YC84S1ycFjS9dWl36PcWAEyF+HJjsljIYGHATb9Lcck7ABOOqnBfzmjswHXnBvUYXqVaoigfvAhS1UQe+AuK3Odx7IAIJ1BWH\\\\\\\\\\\\\\\/voUModARN1qy2hk\\\\\\\\\\\\\\\/r+YMZxogTqt9X3k7E6CEl1oiGDpkGbI5Yr1POcu2s+dmffftIbUr6Fs4OMD+zCf+GUzFNRkNsm051v+N48Gbhv6LP4e7uy8HnrMx9jqZTvKNRLPpZPPUdmbOk31Zot5c+LY8SrmQUCPTXkTJdvQg+x1ayyzggAMDKgXVpbc\\\\\\\\\\\\\\\/pvbrpmWY3nnKW6GqtfrOp1GmjZ6uRYZLajcW\\\\\\\\\\\\\\\/EQq6kX+mSREoJzIzPZuop1loeY\\\\\\\\\\\\\\\/7+jsWrrNWW\\\\\\\\\\\\\\\/xqsnlSb4BwgKrjvkj4fdaelr93SYuZ5nX6dddlM68wQU8jFnTDT9th5OJp3\\\\\\\\\\\\\\\/khtoJNOrSIzF05Zo3OOWzdZm28myocFXUlASmtuGFn+5HTCvUF32t4hvg\\\\\\\\\\\\\\\/XwN38mNA8Oaw2n3cSNNBwzxfrwG4u\\\\\\\\\\\\\\\/wLJoPSn27Ldrc0EEYjkYM2CcJbCPPoYhzgG9Ebcr4r7QhJZ7T+N7TEjt4dEMhLP9VLD91eAOTNH3bEO8j3oNKtiXBEoUN8iu2FmW5zBLM8pm+GtQ4KAm+HoWln3ZS4EwJvmOaCMiogzute5n5t\\\\\\\\\\\\\\\/BlovSPzKE+W0nKAzTBQePv5FNMTkhs\\\\\\\\\\\\\\\/Ib+BSYvUOVMJfYOHAkR2fJXvnBGZLWUvyg9xid6Vh4cOWAxOhGNatqJakIeyied5gWN1zPmo0ezxUZIoc3bvoYQsN759pVVy3dPLOheGQx\\\\\\\\\\\\\\\/u6xYmVmW59+2Cll937t2i7dofUTCXaaWnv0RUP9SvC2kb4ggkw2PyLpxgs0Bt798NkL3u0f74j2TkI+DGHLqOim+DKhaQraoSSVEh1umQknYwYqnhzdVjElLMCfu0laHHreufBE2cdwu+le8VocykfyVwRyMSy\\\\\\\\\\\\\\\/bNzDP7MsIhpfgIaZFBWaUilyEyxD6NVSA2JQGXI++wDe4z6l46TrX1vDsChxn5lv17zzVVP\\\\\\\\\\\\\\\/mkhB+tAyU3DlV9dFUISHxPoK6CIGddStN7IUq1HLMLUOUdD7SvLlWP\\\\\\\\\\\\\\\/w0dN0nKySo+LFF+yNhCDa31RxRkp5SUGAGrT3TN+3709X\\\\\\\\\\\\\\\/HhiYHM5iPPqSVgjYPxuL7X8Z+A9+iYh8oZsasId6TEK9XLji4YTtx5X3BMvuhJaYSl2d4+4MaB6atPg4uONhymh8QYjRDueXfJB+TMyzBKiynwdDNI8RiQABz5PsEhm67BkhMjLFo3rUg5zP2dyFVxNzfvq\\\\\\\\\\\\\\\/qmTybG4t2otXN0AJPKJ2aWedqoIuFNtF6JxpA1pxkNU8fYHHQTO1m9J5LywnYlAzCTV0HA4bIf8fuYsJj0NQd+VZaIbpApUXsISHAn3tRWJo23drW+4IRLPmzkHC3H47GXP6FGxIxooH0gYj8pCmLvgTWbz1ISDJVjktLhVTBxDrFIxpshQHsAB64MXEk4jAuuzU9dgwq3EUzxdKTo87+fLq78KkWkvIzJSjpogtMXy1VicqLMvlMads69Lh0bPVvlvRrj0ZoDNSUbSAdPU+LRHQbd3bpqniOjm6gI0zfmpADqOn15aB7oWYn3Q0d\\\\\\\\\\\\\\\/3b8AAfJKiTCo3EwTwkTdBA6TrP8cLK+j869tyYZHiOlc16zInsJswhpMPkmPDSK4ULhhsxM4dTzep\\\\\\\\\\\\\\\/CX8zR1YCdUdi1GcUfp1LYPJnU75LS6CswNf4wp7A\\\\\\\\\\\\\\\/nK9QgfxEkfjktigrbt+S67kN6OVCPzkMVkEEvMMV+9cVtdrp+9uhoyVHxcWQqlp0xoJOzB2jefHGpsJAqRmaViCtOFLxlBZ5HfPmSa4KCXauzzo+2w+6Lk+gYKDD7yh0cJlg0Rf56ysf\\\\\\\\\\\\\\\/57VbJ+dj0bAx8a8x+22iWGxKCA\\\\\\\\\\\\\\\/aDRP4QfNDrrKHoNj+Gd\\\\\\\\\\\\\\\/AO5hFCOQrUsOGd4ADGZuxH0bzFS9Q22Wlc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022jo4dSkOGi593N4gCUCs8fw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f180c01c4d0734ce587e1735b108169af03d44b22b6178cc84f7f2978a4c11de\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/2\\\/e006822.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/2\\\/e006822.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006822\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006822\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006822\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}