{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022dn7rhiIzCGUDde\\\\\\\\\\\\\\\/um1bfHTBBD6yGI5IriyJyMfwgb1OEwKPATQmzJD7pJd26dzLHVb4yjMK5bG3WeLRGWccxt3WwqHOma4LyYG46UIL+vpwMzvUCoHgR\\\\\\\\\\\\\\\/DDG8D3JeuqNHXFwSadOMABgpvFhVXg3NdAL0yKDc5bjpSqC8WVPChZQHoKUbyrFxHsPVC8p+gtg5dY4mU\\\\\\\\\\\\\\\/L8g+w8NIg5MGu5378R3N1Ha27530B+10i6uVMSnRRNGWQx9XMj\\\\\\\\\\\\\\\/kTeGGnszp8jfxWTz+s+DrC8RvpAJzuFjNYG0P4KEePwPPVSV6HPcEQVM6jp+BBa8vqWwrMH7YCRiogON+WeT\\\\\\\\\\\\\\\/PwZGEBBuwWwksXj9bB+igPAlCBcE4PUcB5HGNmEI8MkqsMmYGrx+MfuDZzk6WqKFzwgF+Swg2AzzEDQYWTvhcFxK9WBvqKfoAit0Yo46ev1sSONqnLZ4yPXZIELgvinS8\\\\\\\\\\\\\\\/IRVP0IrgdxBtoxA+YigADuC7\\\\\\\\\\\\\\\/FLbLzKwENCNdhyDnVyQWbI\\\\\\\\\\\\\\\/8w\\\\\\\\\\\\\\\/NfCr4Dzd8mpZomv3GHw7\\\\\\\\\\\\\\\/nZHkrGzczh0uT2uQ\\\\\\\\\\\\\\\/oSQqb\\\\\\\\\\\\\\\/ygW7FZTRmIVumrWD9mKW\\\\\\\\\\\\\\\/VD3vO3znLIuU1uIBZWh+aHkdS4\\\\\\\\\\\\\\\/043I9Ftv0ueA1OlMgM1G9oXS55yqwAeaCzNYk\\\\\\\\\\\\\\\/dYMEXMZA8yYYI\\\\\\\\\\\\\\\/Iu8VVBpY6sM3ZYSIp3melu73i+vg6748ky4HbgKpopE7H1LURbbjJUPbXqYpzPlCvQA10jCq46lY5iV0gq2M3TnEU+9LwNMls\\\\\\\\\\\\\\\/kvl6a5FPsE1bESPsomYYPP2RxK4rzLSSB3rBswHxxRKkIVvcKnsuF3VM53BlKYgJJEqQ6Aj+pMDX+hqlNJaOFhMRQNGTIgkSnsewwpYtrGnnNHTI7vSJWhxLPUqhX9hzVMmRN8UJlBblPMxvRAtcbrGKF39qsUxGFhOjEd2693mVAmv\\\\\\\\\\\\\\\/0OXqGsDj2xsvobcC+uGe\\\\\\\\\\\\\\\/WAeL6gMq0W4M1sNbyDmXS4xIHkUn8k\\\\\\\\\\\\\\\/vIoFDaOGX91TYis5qVlFJMRAsleSZoEYphw8Xr7mVOZLph75IpUPxHmhICitEFF0t13EC3LdnHCjuQs6zjKJl+fVDb\\\\\\\\\\\\\\\/Bv\\\\\\\\\\\\\\\/2ZPMP9gPX9cyuwU44oJZgI2KlsSz69+pAbc+WW7+MU5RxDi+NxlncPEOXJWJ4kaBVYhjhk0FEBruDZioNG2QFYB81N2MtEviv74xRm1EkNweMyrxQWyaGksSHqHN1\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/prxL2w7n3T5VJzonmg5DoRPKFPEYF\\\\\\\\\\\\\\\/fJs2i2uzAA4cb3cnOn7+5AH4LScYx5M6W6tCJIaSclhzR89No66mxiewxSeiGKcnLEj3T1FhNuw6Ut0LjS1GVgsadC9q+jMZNvh4HoRmjcr5SVlbspBQd1D6o1di1Vy2Pq35gyvMMpZn8NZdO27grQBTgngWIQ87aO7x9upT\\\\\\\\\\\\\\\/CKqJY0NTO2DMXKAcBPbR93W7Q6wMENU\\\\\\\\\\\\\\\/PI2iAt0FhuxC1gPO6yk8NW8bV\\\\\\\\\\\\\\\/NNx8l9Y2WUmnUC33NIvQMrRnzdJ+eKqMIE5oV8NARM5hO4jY9Rr7Hi1y9ju4Gy8lQuIjTjFqoZFhKhOQN2FwSATUp6mOUZMeZY8D3\\\\\\\\\\\\\\\/UYbr+lCc9j\\\\\\\\\\\\\\\/Vl1mxat2FLni+3ignCFmtmrJUc3mMes17UI4NTg1PSLDDcJSb1IYKWwuKtl\\\\\\\\\\\\\\\/CFu\\\\\\\\\\\\\\\/Mwa9rR3DhMUIryi1I9dOKhkDxfRllJBjJI+eTihkcHJLVtTbbz67EbGwYTJO+pzQlM\\\\\\\\\\\\\\\/Q4gw2JvAnGfXdTnT\\\\\\\\\\\\\\\/KZlTKaxTFRiHmpuW1PSQPnv96KcxNOLYs73jhEkmQlEgPu5ehkmi\\\\\\\\\\\\\\\/l6i2afGvU6NKWWjf0Zmb5bPbhh8p3mpZAnqH7d8eF6OvHIjoCGK7CShEnYFfe\\\\\\\\\\\\\\\/Sc\\\\\\\\\\\\\\\/NPHvf6goBGpyeZzPVTPVThsSBg5\\\\\\\\\\\\\\\/vEUu2kED7HU4Vm9U76qcUrMaa10KQppUpvCANSEMeJeXoep1r83AiJoXKQ2dt8i72WWptvo+ByMvZmRIMndnCJ5qUj9vsX8Kkoqmkl3702k7wqsFl\\\\\\\\\\\\\\\/QIYCudajEvJb86DA6k4Q97daAcTUBIJtpCL9IbpzHeBuhbU532rJAMFMyVft3433RIV77Q+A5sK4Ikyz36\\\\\\\\\\\\\\\/qvmTrX7nLSKzOb23y+3GGAXpStyPd3DJq\\\\\\\\\\\\\\\/KLM2wb6sYRRk+LMGJ4qerepQOv+95sF9j6T4GVsYdPlndyVY8TfCXTOqFwPs1t3p+5+DxCJW2wokQz54JDGvoQ45GrQ+rKHcawyRYb0ksQSfPXAodnAVvJBuOKgZtC84qeQyU2koySd6ki2m7hgWilEut06ped1qvPjkKm5w2C7nw5b2MAEMP+iGv3ZERtpnWA6JOcq2Rok0H7iPsUv9FSnG919WKBAZk4ULd4RkytjkOpOuU1nfKqnN+C+st0o39wEEV7pYrc3NPwuSTMgAW5Eczc5uVASq\\\\\\\\\\\\\\\/DGcctQLRlOVzjoYmrjFey40169oHy3KGxBtI1IkKyg5QhprFK9YQyiEqnjyEuDMt9fP7x3hEWoysmTwydzTqqVnNsa7bVhwDpVgNA4o2Kx2VCZ8VYGUwrAy9UqKdx1gN+CQt7vSP+jNfEQOqgWcL1hS1v\\\\\\\\\\\\\\\/w6\\\\\\\\\\\\\\\/t158kRHdfKRVFjtXuU4y0oYuT\\\\\\\\\\\\\\\/UytR8m964iLEtqaELqdD1w82J7EkI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022BqiWxhe0b+OreFF0NW1F9A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022efe060ec039b4545b8224c22de09dd6e27e0176d89ac625dd83ffdfecb3b27f2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/1\\\/e007829.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/1\\\/e007829.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007829\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007829\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007829\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}