{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022vz5Du4uxFhM0\\\\\\\\\\\\\\\/dNmcwNyJoEky\\\\\\\\\\\\\\\/sUCE1P6K9m9pl680cXYd5ax6uvLBs+8ad3IY6F3\\\\\\\\\\\\\\\/s2UiU6L2qx3pOn8JKl4X2WPQjL3Gn0tE19AKjg+yJHxGCCWoEspbtu9QB8R8jMFeVQhYUawaNJp045s\\\\\\\\\\\\\\\/Dr8KDIB9Dj6f8uKLs1X560p7ro7dO\\\\\\\\\\\\\\\/kCY\\\\\\\\\\\\\\\/QYCkXmlhnar495Ln10XHQLXLkcR5iapVSgbSz0KJMekb63erZRDOhOI4V\\\\\\\\\\\\\\\/2KvB8StgYWgCc5S5yD559nLdW34bWWeHGOcTHHH7v\\\\\\\\\\\\\\\/qZFp7XVgkcdCCW25OIrquGJ00l\\\\\\\\\\\\\\\/cGEj2Wnu8aVH6EgU9bksXGK2AtpqYxaH2iw1TClGkD+24Li+CpxdEmzta3zEPrzVdvAA0pSkeY\\\\\\\\\\\\\\\/zTxh60ghQrnRrBLP8j9YEGFY887Y3ik4MF29jusFs+XXOsgTMXg7f+OhlJVX9Lygb+1JM8i+nr1Vegz2KDbSqtgKuNeiVs6FnS\\\\\\\\\\\\\\\/xb2VP+P\\\\\\\\\\\\\\\/z\\\\\\\\\\\\\\\/Jec6eFmmqM8fMF3sFarLQOOiTqC8o18wVo5I8wUEycsj6Kq7ouPV9Osnbm9yWaJGI8eqrJh0cj2Il46djBQJinvdkKXWRszIE7dLWSZea+CWInQzkTSHijMJg6m4zWRqa8wFhK8IoLhsBt72R8B2dgXsY\\\\\\\\\\\\\\\/hghaRcWioAxyk3Bb7PjCCSNiHKz6Zi8MxOLzcNFNjcDjnITO\\\\\\\\\\\\\\\/gO8nO9jr9gEjtVG8ENf0vokQ7iijdRJJEnpXgucMFqWI3pvGmE8TiszsQ9GncQlJGkoyiWlSIFmICJHwfACoXjZDe3NkNTBBzvCZXVKvAtBnlb+0DI7buHNfJJJs9hlNrcqvwB6iZ6k8IJ4Qwsbta7KyWL43RHw51w3lfik4lQikRr8FgvQJF3miiSGYOna07\\\\\\\\\\\\\\\/BqfN1C3E0w5\\\\\\\\\\\\\\\/Dek7qOBkgilYzMhD+xfeaEspGmJNJCO0rIFgzmrHn4NT7l\\\\\\\\\\\\\\\/JDTuV8gTheNW\\\\\\\\\\\\\\\/qjSIOIS74wSMKsogwybD4rkISLAgdnoeIROwJguplw6SVZuNZxQ8sUguMflbE+uwSQ2vrK7T7CQLX3fa6\\\\\\\\\\\\\\\/H+HCRmBLdWNi7iO22joYXcjOCXvYmasTjo0knGblWqhHH5gGqcJ4dnZu4fZHyYC4tPPUxHP3P1axp20MNGHHhVhnTPNkkD8KM3JtUsbOrdVSZ2Bx3kG8BgF4B3x1KV4RXnaNnQZH2P6BmBlCYRjOa0+PFcHgdjSSdrU0IyWMu\\\\\\\\\\\\\\\/nlojYGkVQerzcgOLrZdP\\\\\\\\\\\\\\\/nhQfrfGQApBGKMtwnmoF2B+BZd9xyvzRVGhNN7GlAAzQZrdkBAc7VbVITQ8\\\\\\\\\\\\\\\/s4MrffvAzXfLYWVSdY3b1W1g7sEsBw+AcUJs2LlmrVwT76p9uaZWdzaSHHW0Klu4ybBZwqQIDkU1jJUm7h4bUJMnT8hht+VbLEachHUktExkI1IZsexFmkcz0c3cSbPfslzRAV7VAFOBDfQv2eAFMLg7qEQf5jPU5lyMrcOkYf8bKKceDG0mXTRyNyNQi+Dxln3qoRWaMdfadT4+JtlOQElQid5TNDXZcvclEHTO0davnHwgpxQYT3k1I\\\\\\\\\\\\\\\/j9h5blyqe42udzZpsSgt6PimW1KqRsAuv75+wNq8j1yMVWCXWIUhH3fr86mieaQ\\\\\\\\\\\\\\\/CUxvn9GlxKdS+1PTcYhq3tiVdDgeuGe9VJFBOS3f4AiLSoAfsw1vjC\\\\\\\\\\\\\\\/1ptDysYte4QmYpRiQzJ2R531R06xns+6qD\\\\\\\\\\\\\\\/x4DADTw1sAj9cseDRtNrGhF1qVRcGa13BeOtLYo\\\\\\\\\\\\\\\/xkIP+oXS+qP\\\\\\\\\\\\\\\/sIlqdSnMJhnCf4l9K4zJNnb2FqTo4y+t1XnfsPDfCRLHtnyRZzbVaxVqHv+XrbienhauiO0KWIUHaTMqVmu2utoXiNcPlBFvhnT4tLzJLeH7jj61ImZ\\\\\\\\\\\\\\\/JcG39FyDIIUomCURgtrkhCR1doFZNq2j1i6xOux3\\\\\\\\\\\\\\\/JbJSOwS5bcMoW7OLoI8\\\\\\\\\\\\\\\/5854NRQmj\\\\\\\\\\\\\\\/ic6bpbPROx7cjCxBo+p7Z50jeGHWYwu\\\\\\\\\\\\\\\/KePZgal7LV4umuVaGib4E7WAeyQbrrzOG8sxvnqiHpDv5V+nqA7NqA7jDfEYEuKFksY200dSRk2aJc6kJPJc9cMytySnIkfX0zsSzdKZZSVSQcWG\\\\\\\\\\\\\\\/fzAEa8I5Za5hLM4e9FaMo6knFfUOp04hgTsl5mOq0zuITyzFPXgXypL9ozkN4ssiA7pgtOA84NCKNxRm\\\\\\\\\\\\\\\/fTf6CZEh5xIWRWv\\\\\\\\\\\\\\\/X+Yd0cWz9sATvPQdP5WM10ab7DtX14miQ+kdrjn58yw7HHKxzVBtOZSeRVtLJM0cIQqO8Tf6d9UfeEmZfN2VCq8vG4cMPMsnQEsDFfffWVznepUjVgcCvxUVs4woT2R0dj4TeMjapOefd+ywEP2BHYQOpo1Rs0la1GtWGGm91lL5vxtQjsd308NwbHayja58Agm3AuVYLRGchJsYYCYJqyuJw9TvrLe884WgnKABW1o2cbihwwh8yNuvS\\\\\\\\\\\\\\\/gzEhQsIE9lIRGHWTWmVvb3c1j95\\\\\\\\\\\\\\\/YXbusSeaDf34RSSxkiqb7twHzlXfJrLW1WFkdHwTIXS2mwqPjTXUoNoXMa2wWpMFCaN+SjUf4g\\\\\\\\\\\\\\\/wFA8p+9xRSxvmxsbX+QB8CSXMiQfL1fywJn7WyK7GNxVz317HDDCdzXcgM\\\\\\\\\\\\\\\/lbn9Zjfzsn1JI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022GRHMBin2zeC8idMqA70Zdg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229ba5a61586454d83ca92865938345fb99892801f8f7a1bcde847767d369ecd37\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/1\\\/e007823.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/1\\\/e007823.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007823\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007823\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007823\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}