{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00227mEhvy\\\\\\\\\\\\\\\/Te2QL7961NueOP8kGRCKFfgP3+d0QpzO2kaN5i7O1Wte9aqZRf\\\\\\\\\\\\\\\/zarG60pcX+SpYbmwuIiquS+CQ5q4OiCnsSkpDeaK5BLsPujhZ2\\\\\\\\\\\\\\\/uovwVq2SPv0e\\\\\\\\\\\\\\\/cDarAUR\\\\\\\\\\\\\\\/50ZRI67N4HD4U4PdCD34gSAVD\\\\\\\\\\\\\\\/DDiET9vXX3iMbZY\\\\\\\\\\\\\\\/wqY1tm2oO0lY0Lvxzsss6hDjRcON4TTJ9W6ar+bTaVGksdiZO+Ml3U5KBD5SCk8sdHnGguySvGjI3HQOFLtWsWkaNz9NiE+j69r7hyYrcxI4rhJZ\\\\\\\\\\\\\\\/BTtm+7PuMzHMHTAR1FaBB93k0OpLA91rNkut9LJPEG4T4WBxZWjEezl\\\\\\\\\\\\\\\/Kfkb5h4hHB0URff5Id1HG0BNz\\\\\\\\\\\\\\\/pKvApSyCczwnOzsR57zYpg0uGYs3Ji2uX0u1SJ\\\\\\\\\\\\\\\/iJ7QPQhMSQX1d0ZFK7NyzLOUpu4trWIbgOQKd4+bP5\\\\\\\\\\\\\\\/F2FP\\\\\\\\\\\\\\\/0IZXjdb8gXSQw8i40Zzq02FqSGSd7MDAmpl+UrQvOfy\\\\\\\\\\\\\\\/r+HgGNBbz5n3gzwa\\\\\\\\\\\\\\\/TlM3uddX\\\\\\\\\\\\\\\/+mzLJYchzZMduK8x96fK5eqVmQ7Yk95kbFCTp6QosPbQZPa8bopFNMvHChtkcY8KFx6RTN0qWIervp7Wz0WSiCAgqPTX6ongVh5zhcor+XDFCB40f468mqMbuaXzTlkKuCN1Jsxq9\\\\\\\\\\\\\\\/yWsjQgBxqptk0DgSZnM9hf0vf\\\\\\\\\\\\\\\/VkWLbGLIS1GXXdzYR+AjFWGb2VDDLd3fmAvtLTRh+Ra6JlN6uWF7Tnb0rSlAVL5+0VpYdhb4\\\\\\\\\\\\\\\/gvE2X8zOvgMbg+oku2yMNQ8mgO+prIENvVmz7qgIGEyPO\\\\\\\\\\\\\\\/bbDzRrVns7fj9zeUrPwk6\\\\\\\\\\\\\\\/E1\\\\\\\\\\\\\\\/ov8tNByd8f5EQaD9ga2sexlpDc0OsQmzEzRavwMec8pgM+9Hcl5EAn\\\\\\\\\\\\\\\/pdFtuWByGAbKERU8aMHVoNd3ZyPAIjqVoTUlaMoUm+v2AYJos53dOd11FOygoXrMqpH+sTcVVbff\\\\\\\\\\\\\\\/JRiHOFe3h9hRXGSwrzapjneJxxClV391wOQ3sjDWSXJe461lXlL8XKI1fQ\\\\\\\\\\\\\\\/QD7aK8AKUJqV4Fuxa+p\\\\\\\\\\\\\\\/Q1UA1TtR3i\\\\\\\\\\\\\\\/u2a+6YV8z5X2udB+BbJF7eiqUEyg8Z+NHy3b1twP5MTKHLfAtIXzbOue+SMcvfS7UiX8Ei5h9XeXmhGVvrB\\\\\\\\\\\\\\\/cOaOtHOt4ezpAsLK35bh0NGQsj5oS6NhNAhgiZF33qdktWyn43WQcVooHzVHzT04qombSbEYy444EGNeOVslAjpX8SIC11EIj9HjtHUsV10RMRxZas8cDRbKZOmyWdMKKdAJYTVY6yFzoMY\\\\\\\\\\\\\\\/pRvmQ27Jk5Mj86Fpc1kAUmk5yvLKl0Qix\\\\\\\\\\\\\\\/Wa9PDhLwN+sv9PRoLQoLILsEpnk1hQ+0kW2JdXNlPj\\\\\\\\\\\\\\\/nEgk9KLb51flFbmmll4rLykH4Znio7L9gjBdp19VF4Fp3zUhprCHk2T\\\\\\\\\\\\\\\/eFwN3DOlvtCXFUUZS5EwrpGhwbGuuSVpIOiDjBH4dTGqBLiMHAffPL8RACerchwVrxc+UQZnyCXcp8ki7Is+W9Ft3bKfIZrLY931w9aO52B4NoHH2KAHkH6Qj1uYDnfZn84p5FsEfN1+NpngoYunChD3EkWb\\\\\\\\\\\\\\\/29GIgUoSQyPerPN1o8Pa5Cki1m2gG0SdJeZzja4c+d\\\\\\\\\\\\\\\/xMwShvRwxdKHFvISUpTseOwmUvPpVC030QvludnJq3AkYjZjd88xyWZyv8+Te+LBYQNyyWd1Zp0Fg+90qaxucdQJ5t+oUa3\\\\\\\\\\\\\\\/4dp9LisSjs7Izdgq2WOKJHpRb1LQusrqUfFPZ6eh5cMr9AyLZgUIJE26HTKwwwtQIHDYzlC3at2oBZ9765mrlx9ASmCmMIMSjQ3CYXR8XQ1QBzibAqa3P0PAPH1KaQPFvwTIXznsoxG01pRHY\\\\\\\\\\\\\\\/dR05yUMWoDZ1hmIlA+yC6kKUKxpiWeCuNhR1NCXjJZfGpx027MgRFHAWdb\\\\\\\\\\\\\\\/NjMYqaANFAnU54UsZqXaHEvB1\\\\\\\\\\\\\\\/eYAvYUgapm+C0O6zZbD8MInf8OG+KmT7Emiu\\\\\\\\\\\\\\\/ZzuwuSAZc2KQoWXkhml1j81knWGwg3xC8M2MIfEV23DKvSL3s3D\\\\\\\\\\\\\\\/qGSLaf9miVvKAly6uPzUXoRY2EX4pDACCweCBLKWfvY2nJcnxnRKH4MtymI8qg4lBavd3tvJfHZ2JV2dKgvnsAkbiUH1XVqPbOMPhwAbyPUxGk8ie\\\\\\\\\\\\\\\/LLguccjRcUSy15YU3CzoDnHdic3UlvHNXSo0gs07mTwRalKoCnIaQ2nntiUQ0q4kWJhrQ3lAhQSQp\\\\\\\\\\\\\\\/MJvleMVyZivwKOA6tbzMUdkgxn55JlcsSh5zBCEg75TxUELU+Zga4+yDl3LVF75MIwMdGKQF2IYmJRparn1+E5R9rcFKKRSRP4pVHexn5Nn6kLE+CiJy5obOpGU4yVHRgGRJAaLtntTz1to9C34n76OqdWKnUzffxiHW5lpMkKsTpmOmH\\\\\\\\\\\\\\\/V9A9MYqKbfUyB7zyfgv7Y\\\\\\\\\\\\\\\/vs+70H98Nnt7DC7p08Om0eEyKknolg8QpXRNzzHB611N75DZ77ZOlmMZyGlC4Nwc5si7SP30uz3fLDm\\\\\\\\\\\\\\\/ta\\\\\\\\\\\\\\\/sWwfTcxrYmerYnq+0Zj6mmogiYa5KvLG2nRtInd64vtLSGG3OHNNMWnFT2I87BtTRQRIk9g\\\\\\\\\\\\\\\/AMgPCPWiK\\\\\\\\\\\\\\\/jfyj4Q9\\\\\\\\\\\\\\\/l24qcfg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022RzpmQBcMTLQr\\\\\\\\\\\\\\\/89NMg\\\\\\\\\\\\\\\/+cw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022dac3674bed4293df7d1bafc1e60a29c1c37905bee3fc3dcbd16363022608e580\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/1\\\/e008138.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/1\\\/e008138.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008138\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008138\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008138\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}