{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ijz+F5Qa3kaW72GxPfjvJsNXKAYgbTIMBl+W7EM4fO\\\\\\\\\\\\\\\/HyLc0bGc7\\\\\\\\\\\\\\\/XoUvHTXFS7fnR2UqBtGbfMybPfKaMp0WCxDY\\\\\\\\\\\\\\\/9wSYslV+h0qeHk6\\\\\\\\\\\\\\\/XJUl1x9Ay\\\\\\\\\\\\\\\/AGzDy8bJeFjj6p25aGs3tEmIGGfrUkbwDjFHez4w+1Jv+7Xof1DLAEafaFcfcdX\\\\\\\\\\\\\\\/6WqcMUk0h31ZPRFrfLLYBIJEZ5rv9knmRgJBN2Fg7rvpRJgUzd\\\\\\\\\\\\\\\/w9gnDJZOntnEI0nj\\\\\\\\\\\\\\\/jsyBqrtvrSuGe1MyPci5jyDpJQoP3bWqK9qZDjk7qgSPwAzy343VwKWTeDMJoPaM3F3yy+Z+wmvj7Qkl958GbAHCY52KjzCSoJlHIa6SjW9+y9W21t4RsgOUti3yEk0OmBNqRyeMB6O1+EMbJHeg2qbCyxDroG0L+PhXGXbkt30SjPk7bJZNhbSudde+\\\\\\\\\\\\\\\/GmeXEu+fZHnMRxhJ5hj+6pfdJDerok3NfU8qwla1Pgks9Hfct2jcv2ub3vyFzSs6tXEau5f9NwQBTT5tBtBliHPwSre8hAmFpiS6lywsez1XIea5PwGi5yr+L5+E\\\\\\\\\\\\\\\/2Qg3xSiAOA4mwirth4oyVUqXMkTRJjgOXjFtoBOdONsPTdng+Z2UZTqpT8bSGmXbt+gncFuRe\\\\\\\\\\\\\\\/Ij\\\\\\\\\\\\\\\/qq2f4eDifvuFarErpvXyrLDcAjtdyVXo+iv0b6qkGWs4Tj6+lQlFsf8Z\\\\\\\\\\\\\\\/QtEvCh3axalm9Kh4Cv2ccqKDMoC2gi7YCXwlqE7NiVqLJPzobnPNxwvMhLc2Crh1GWmWm+Ue0myMdZaHpehOKZUZLt1aj\\\\\\\\\\\\\\\/GEcQEnQ86y4j1cXI6w1+CTfimWpEVsNy6jqjcdg2l+XWEM8LGcicYqXypK4JU2UwUgE5fQsLkqWcYO83vNW98dPnBCdsFW66isSmW\\\\\\\\\\\\\\\/+NtiV31Grnvv3Ig8cYv1BTUvPZ4u9EfO2Oe6k5lQ3dyppsAJlnsevnLRyJmhbAhD53Unjst9bAT+RC+VqBY50fG8tR0QvthUM+yhBVd9DWoyc1Dihb\\\\\\\\\\\\\\\/MUIqZ23lgjssGojHFSLMw4j03vbr9ejtdWMBzBaciL1qtifK4DbkULJaL6BEubqKbEEGTgp2\\\\\\\\\\\\\\\/mVLm0tYtZgeMqikNMts9A1VW7s4tmyt5eB0D\\\\\\\\\\\\\\\/SdRzEzN3TWTg\\\\\\\\\\\\\\\/DZUrbmUF4FBMXfi9sgwrY0TWjwluKtmzF+1oFZ1BsQBMuHgG1F9fwAYWmtjrIIa9H++CHmhR9wY72HFPwUaQ9mVyCzyKEH9XCMioxI11JqTA99WSDrmIKmIeJ2YUuYIpXo+SGo9KbSdDdthRntbu+vxTU0IpLYHP+0x7i6FpkTmp\\\\\\\\\\\\\\\/mm7e2vXORTJOwg9FL\\\\\\\\\\\\\\\/KNbmmO1bBMtuqjZJanAZjJcKZ0zQWamiEJOpWCEBN8rbTxe71kURkOY7w9qbII4C2Wuzd9hiMkLckHX0iI2livJx0z1+nvlD6BWXG8MBQXTyY5QSLL7upA1XeShl9YqilEO8VqvAdUiyXk2eE4ERnV33cYgpqJbFIWd\\\\\\\\\\\\\\\/3Lljzq\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/WG7DtNHy4JiT54o\\\\\\\\\\\\\\\/9hdBp6Ezjz9KeWvPTJ79AzpLmZljXQMuF1erkeV0DwcG9WRgkCtt36I+GRdDTIpWlrbB2X9zISoofk3jQa+xwBTQKdJm2gLALp\\\\\\\\\\\\\\\/OcorqJCA5W1N4p6USSV8R7D0UHIGG19o6uewrgVJeFucw1JQGcwKJOZJneauQAs1MSNZFcObB1OSrKVmJNm4dLykw03ux2mMkNhx8+7Vpa7Pfv2Aki9ddodlV4W864Ca83dF7L\\\\\\\\\\\\\\\/Q2leo+P5Ieuh0EMQqP8l0JJghnjq1MXxUCSZl7Hsd2f55lOLnnpOHZXJOoB9IG51CWZirOS4ltWxFGBfG0GHM3CUUoDZp06lJI4HOHV7NWliP7KPMkegPofLjDCN+JpAF+dPgeX32sA1OVDS34bgkIs+YY8jdHlqq4A4eHRxOObSyKloFoX\\\\\\\\\\\\\\\/lEFNTef\\\\\\\\\\\\\\\/kd9Jsy\\\\\\\\\\\\\\\/iuxGFBBs+fq+o5VmmVGcTQNbKEdBQIOEMph1ytE3nlRQur8MLLhEO8SmkrwYYHPKQGdvzMmBfSzemsO4+cIwRBRCfk4lrglBSHzIBj0KFE2A2FJi\\\\\\\\\\\\\\\/Ov67VU6kmC\\\\\\\\\\\\\\\/KhJA7GtOOTDXxUG\\\\\\\\\\\\\\\/Q8SYKIOCFaMkiL8QY4ZSE0+4dZjf1\\\\\\\\\\\\\\\/MCn1pijktcYpyg+isfymP1hR1McGePNxP\\\\\\\\\\\\\\\/vWBOjozE0Cg24kFocSoJBGA7vDwuLGpwXo35KNUe5s9SVyWXDLeMZLSSEiz3ImL139o0ICbzu+Mbz996rb+lj0EeU8MUZiENIx\\\\\\\\\\\\\\\/EmJAPA5581\\\\\\\\\\\\\\\/slXbXxnJ4yMv6t4qAPgiTMf+PRi2wB1ihTOnqACBAyy0DD3LoIj6gL8oOYAkoZhyU5IF2PxTtBRxB66aFaupzMRHscps4PkSqUdUJVh\\\\\\\\\\\\\\\/brkzxRhGmBfjd0PyQznjQROrMWPH96+sNm7LVqlSkQSP2uxc9gouQVYRB8QhYSnlO5qmXg+pP3PINI0G3EWdWPl4RZjgFmy3Y6l47Xr18dkIcM6iy3M3azpiELIAePtNUmILOORy5MfqUXhOCZhj6e8Q7PCPgPU1r\\\\\\\\\\\\\\\/O3FEATTa7z6UC2XY+1+AhWh9lroTMsyb+lkorNchrxz8Xg7O7uD1x7xGg8sixcDKGRSuL\\\\\\\\\\\\\\\/BOS8NEEAJPLbBuM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022gCt0TDiPazfFkzG0si5Z6A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d8b98a8f4ff2c5633ffaa9bb5c9278f23dd19fed6aaac61066a5b607e556f362\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/1\\\/e008367.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/1\\\/e008367.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008367\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008367\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008367\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}