{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ultJAz3RHBcAYkG\\\\\\\\\\\\\\\/ZPfhJe8s\\\\\\\\\\\\\\\/TynfPZPMuUkUIMt+nc8+VWrZ08rulm+CgEpxV1NbN3KKe0pDT+q6IJOP8qlPyT8sfzw46AXYYLdTSVeKgcQqxN9r7CdVvwsyJHNCJcFrhL2DCTkIdc0oZLEGY7dK9HyJuOM2UPwTIdaBPTphDb6TYVz7e0id46GfSCTJxYYQYQ1GLv1B2XlWfrrylyj2Uv0hK84lN9fg\\\\\\\\\\\\\\\/89KvSOM8UjC5dTs8xVVKbN6anhc+YorjJP4hvb3H3CZKJBZIJrcikRIioHD26N\\\\\\\\\\\\\\\/oEuowi\\\\\\\\\\\\\\\/Mf217WTXSUrqaaPSpgTB8REF\\\\\\\\\\\\\\\/ascRVXo6V4bQQ2h06vv9BZ+6sGZz17oV9fzu8UaaQUIJ4Lk7s9QdDeT40vDehA\\\\\\\\\\\\\\\/9W9yNIjD88kwzzXceuT+2NKpjPxbsT2dwq83VB7ScYYL8pZDlZXC47HqCT9exFOtqOl0RJ+3uSZXv205XBPAOApBeRif4\\\\\\\\\\\\\\\/JuJhuS92SwbI5RB0MKNImecxWiIcD5ipWXUfLoeqQkgnhgDSfqjYFJvWrDXJ2Gm6XKFrnhfI8cfP5D6tNK68mNDZmIMqNuX5mm3Dq\\\\\\\\\\\\\\\/bZ9oVTUZJCJ25rirLqhXzEdbXb1y1cC20+KkYbR50oqVnOVx08\\\\\\\\\\\\\\\/sVasLN4\\\\\\\\\\\\\\\/AgD3jVEbvwZ0TeC8M8FlcIRaj93mMCyNaJlLyCuUMzWV5d48bt5B58H9AS+G7bYW6j\\\\\\\\\\\\\\\/sChzqmmIlcWyvCCJHy+8S9\\\\\\\\\\\\\\\/MdcfIu\\\\\\\\\\\\\\\/se\\\\\\\\\\\\\\\/xbH77APT+1FxkyXmMQk1YMfD3JfJ4j9Lgkh+EkCk9efMr2nSkpQ0YI4aEgKaVZBVnSltdujw9dPP+RIGURH1PQnhgsuMJoNrJPCOZXvBzKV0sHyIemfWhCJ92KmG8PcCL3dF9wNwgg3gCHROfuEipPYnmNY0CZoGq3CB5TzNKaRhMhDfIfK6bmYUUirZu9+m\\\\\\\\\\\\\\\/T7Aw0Nf1+hYIjTxdJZXTrJCknndgyKeBlWs08ZuTN9xhoZwAqToeITo+zK0IU3IAN7Dq9cpWf+6VQuD4odhb+7sdH+hrUzUR3ubWZNMxZGcQ57p1uaPnbe7x+QGpI4fuyg3G8qW\\\\\\\\\\\\\\\/LiMaZGXLdiPzSvJi6mL+8QWc7sROH4zvHRFW+ypEL10OguCehMcxaKKFk9TSW7w\\\\\\\\\\\\\\\/KhHW8GFpfSMpxfoJYiDPpHk98hHThbU0qd19SIEFKGDjTwdhS2OcQzUvKOijuuZd1dEl7CjOykx4rkeg679knLpbbo3KcfLYm9aLtIUY3e9u\\\\\\\\\\\\\\\/1Hrz9vMCHvLbIYaAwBOgEtSdJM9SWCG3QbP3rIhNej9FTXRpYUMNKOhrdxt+cWQHbKSFhP4kNeKA8e9k8J+sn3R1cujY7d\\\\\\\\\\\\\\\/seLIW6PrK0ScDnyWzNvFDdO9PAKlAezGi+zzKMk7ETNR3YO4FJmu\\\\\\\\\\\\\\\/g6k5FfSwAqsLndqYPcdPG7PQz1EFEC0S7S2RpJDLZcAMStEiKlv\\\\\\\\\\\\\\\/ncqFQDpIGbhDWJ7utzydm24rJGDCZz2c33uSQrTcZyVC0MlW7FS\\\\\\\\\\\\\\\/DmEhcStcQ54ZiysrSXgVn1Cn7lBZNXY+eijkXwIEKTzdvr4hBP+QWVtGwA8V5XCxewbbsTH1tH0nXxuGBzRNWq67AKbGfl0Me9yRfycro8jGJSGkn9dhW3uf0w35wOTzbVUnOKlMraRMgESUlGzIcfvs+gmMsiBD\\\\\\\\\\\\\\\/nVfqE\\\\\\\\\\\\\\\/v+RdKofB+xpwuojOCYNLHQnqE8qj9a+7fvg0LAjJ7Jnkmf5rr1ZJicKVEZAItR9dPYA6xj0IqzsuGxPISZaUuI1u+HCQzPeFFgdL7MrDWo5UGABoLv3Ukw13mGlct+bQg1LAxUiulfMHFul4enop4DSwKZDi703Wn4\\\\\\\\\\\\\\\/+SCmj1ecJx2ETBZOK4C+WWzHjpTZkYti6yOfJ3StKOXaCwz9jClgha\\\\\\\\\\\\\\\/9vxYZE9ei7nTnLKmj+0zT6XYQF11cHzxzZslaAhYTu9AdsqIvpyuX8AcT0q7JauX72vgZPoJsC5hNrJUDQWnxDVW+qjUhumeb0q9ZRinWiusiONDo9x0DCseCoSBMggXkfmbdWKI\\\\\\\\\\\\\\\/3icBRPM6iPdaPIWfGiKuj1olDQ3NdNJ5lOo4Tk4Ges1ELuDD0pCkMzbXAUJwN4czJpA\\\\\\\\\\\\\\\/XiOiqYic0ZDyTDd7aFaZTggvS+W5aOXnvDsikqnXGlHR4jiK+6ME2qhXG3YRienMEcBjTBmEHil+Q3XSh\\\\\\\\\\\\\\\/hJsecOOcp7Jyrv\\\\\\\\\\\\\\\/wOzgRqrFun4QgNhjyC0CkfB1HR8SMZVAz73hblLH9oL9TVKHVneO8ePJPeSd5eyd8V4UuDce8Ht30b5iJx3Nk2HnJZIcyQ8itv2oImtjEzJ\\\\\\\\\\\\\\\/kfl6qlgdml1By6PWA0fiOd3uze09eGLtOu31MQ8\\\\\\\\\\\\\\\/gzxCmMjNr46b4WIcuXEFBxhLm5utNIxOUDBltet4l8+CPE85boTdULka6EY4xa8n0HoRL95NbW\\\\\\\\\\\\\\\/ZGqbbVDMbOijE0TNCufww8h8ICHwgz1uORvERWzk5kEgbDV\\\\\\\\\\\\\\\/VPpEv9Ozwm\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Ch7CmrtrxbnKpFBMhRWsNmWROBGYlqLByPE8xtPxtMYEj3HAf+PyPSJjzrM\\\\\\\\\\\\\\\/8JjA4cDXSR3TAnMzzULEMGWiyAXBHpz06y1w\\\\\\\\\\\\\\\/F4RfK5ZYLXpzfJfJ+\\\\\\\\\\\\\\\/WFGxk3rXTZSDwm3YbbU4bI718=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022MkKBRWap9U8TsGTGd5uA0A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c8f44168ebbd465192c6219bc420bfaad26c7adb99830c00c534e2b5f208a3d7\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/1\\\/e004592corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/1\\\/e004592corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;12\\\/1\\\/e004592corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004592corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004592corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004592corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}