{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022X0RPxFmRFu1IepxpSyXf2QEBecXKiY\\\\\\\\\\\\\\\/hMzBkBYXvnsNNTa9732icBeqSWmKyN8ur+j3jTB2PX6UQM3NWgtXmKOFgoxHvBoLQhDkN\\\\\\\\\\\\\\\/YXF6V9xWsYLxgnlMzRNqiyP+pK6BvV9z+D+b+YMtobRCI+Ck1Kge3RMxJlJdULw337MUfzP4vwBkF0R6tYzUVJdqaNAai5B5hhHP2fMVQgYUnJH4DUt\\\\\\\\\\\\\\\/SRzd01b1j20kFVbMKUv7LA+k2tI\\\\\\\\\\\\\\\/iScxNc6TJt3HdVzeHbLUErryNsfX+QVCuPF5nfaih\\\\\\\\\\\\\\\/sYobGqgKuyUTYiEGC3Ifk4npiTSmqa9qo3hKK0PbPqFawuAIorEJuP8JsdEIx0eViL9r4iXs8oLLyzinSxFqiM4emNJCuBmZrtGBSKSww3hCvvjxiRjLhLNUhcl6FqWpqIrHWQyaltfmEl0r59LtIDVwqB5A74DFACrckQX7ShPeCepGnsRRMkPIdHWJJlFLhY8n914\\\\\\\\\\\\\\\/LIolyKwr9YBA1jE\\\\\\\\\\\\\\\/RpmVM\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/aFxT82zsUmdTB5X9yqpff8ajrVxzMtB8LmGbsRrTSrIQgf3thFo0GPOj7hMrVb+WXxUaI8G8p6Z9brTqf7nDnX8kBcQrtzHSlY1qW1r+KyHDGxKt\\\\\\\\\\\\\\\/JWkB0Df4Oai3XVRUgKUR52L9UYcV\\\\\\\\\\\\\\\/ulgX3nbGCBAeMUbSG8P5TcqzmpCyD6FEHC9LeojdymE9dOYESPomYczIjlEhewLZ8z\\\\\\\\\\\\\\\/SBTKI+PTOaSJRzqNuENfSrceHSAObkoZ4gOSicJL8w68MokxznXRhbMlotutYeuQWR6gUvQKuAykbPwyN3gK3PMpvaNFC3R7SESuZt6Af9who1B65bmh6oVBQ3Fb5kOZNMMLmBb1GgJsC8wKRCnRDhlDRAttVjeaLmilJzuqgNdv+p\\\\\\\\\\\\\\\/BxBrkD1vsxTUtNW1MSQgpEpHb+aUTCVpU1kfhq16JIgAWz9qcBelQEIz8Km+I4\\\\\\\\\\\\\\\/NbLzZDM6naRCiSpVpLOXb55r7GOl25toFi8jFZWBYKj1s01jN4H\\\\\\\\\\\\\\\/8niV3c0Le+rrWqOExcD1Oy0mrVhWFcvWG5fbIbgMucEZQymt2GZ\\\\\\\\\\\\\\\/mno58\\\\\\\\\\\\\\\/M8bKNOohA3bf+gJnoLoeesEOKDOTx3Inhwbq2Jgi\\\\\\\\\\\\\\\/vxRVlXrk8h8Xk9XCmcs+Vj6ExK3tcy5ppbIW74QM8zxHkwqM5J1JB0FALH9VyWs\\\\\\\\\\\\\\\/QytCsdayEILTrxJK0T6inlrURZZ7uq8zt3LajPmOGTZ1tWmKmDRh34L3F\\\\\\\\\\\\\\\/3E7WqPiMb6qR1Hr\\\\\\\\\\\\\\\/HEZEhi2HT\\\\\\\\\\\\\\\/NoL+u0I1HgMAY+G15Zh8wvAwTsW5N2O5hC6sHup7FcAx7p4jDZZXw9cN4yKTk1buq5CfXAegQdoVO\\\\\\\\\\\\\\\/qoNOASrW19I3U8QnDohM0vttN++8kC8v\\\\\\\\\\\\\\\/HqLZZYn3CCv5EUmQsUbXt8mQH1pnaaNQYS4cyu3Z\\\\\\\\\\\\\\\/oo5ChcQhLb9XtYnDCuxr27ESdpLjOd8e7p\\\\\\\\\\\\\\\/cIEPs4vhKRT5gyPhRNUESpZiiZN3389plHeixkqq8AInQsvnywyf8jL3gjlWDEx9CAdw2cPMLdiJFw4Ce2cmG0l1QES7ll2p1jo2QpWnZCR07umg35QKxBTfzTxnmYysD7Pm2fJ7JpUTW31Tc+N1PkHjiJrYUQkwbXh8I\\\\\\\\\\\\\\\/8LAMELaAstKmmihyjWG4QZWADO796Ktgo6XwHAoot2Cn20tXgzwKM6dUzvcGme439ymctE09yYIS9g2Ck+zMbPjhlwEreIb3D8DNRUlHl4dW\\\\\\\\\\\\\\\/6oYu30LrTfqY7kvaaJ9xmn+Cx5Dw26i5IS0KsX8jf5\\\\\\\\\\\\\\\/aYQpPOt7mrrboVWs9N3236G\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/yiCLGmSdbU07rHxyC\\\\\\\\\\\\\\\/n5vy6DSTaG1PIAODzySf5irrZCZ5aAt3mQld5vfXSwVJW7mZreOgMiZG9c4OdZp5EDGKnF2uqvj7YhaXGNvFZvnYh\\\\\\\\\\\\\\\/Em\\\\\\\\\\\\\\\/HCBC2W9CiLOiz6edypvYsX9rUqSymWHwTYdSkot3kZMIhhyeJPyg6ZdZ9cOOTLjWmkxswA0aR4cTEHCLrDaFWysm1\\\\\\\\\\\\\\\/9\\\\\\\\\\\\\\\/QpbNIBTN3hLQi\\\\\\\\\\\\\\\/6VAHaUPPQuD6sSKGeY4j0Sv6Th7S8S6\\\\\\\\\\\\\\\/XInfCyUvID2PfJpi1BGEXR0+aqrupooZplFvXyo3\\\\\\\\\\\\\\\/T+Nlx6y42TtANz78yCl26JNHzvgxOMmO+i8L0CGbEJU5Qjx2NgP0FHOpZug8dWUKBVn\\\\\\\\\\\\\\\/bwzGPm4ExaATQV2PvhbQZ4awquFeIL8GVamRFpyk8cIDL9RTyGhRenELbZQQnHuPxUhf96z8WD7S\\\\\\\\\\\\\\\/2kqvqjXK5lcbbN18JNl1r6UNrB9NTNuvdTPb7f2+Sgc95OmSblExmG7Tr1G7Sz9doNn8LVy4x5mjyKGfk695kuPwlgxFwyDZE24o7njgpgw32f8wjTpbWehi9kbkipws0upKTMWQFr+OQNkI4JE2C2ii0+lm5EM6GpZ\\\\\\\\\\\\\\\/Tsg2PTT8s8En4dN7GXKXSaiaTN1PH7uE326f1\\\\\\\\\\\\\\\/BZ4BD8+XafhnCCHCPpo2csqsRuHhgMIuylU4If20bRajZRphDEYe6DNZ\\\\\\\\\\\\\\\/RKn3bJo0Q4x7a6w24+hRCXdM0PSwmGlThXcVxBTQqj4f93Q8guJSApNaUhQflnEkMXk98yD6\\\\\\\\\\\\\\\/Xv7wvyCrd\\\\\\\\\\\\\\\/kXFBARojq9OzT5q7RKTF62KdGRESoNGUwiwawvRs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00226p6eiyGFWIyrhZXpCG4MeA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002291ad9f48e30b2b806a29a702581dcffa88a344326548ab015e260e454a5ed3b2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/1\\\/e008148.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/1\\\/e008148.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008148\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008148\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008148\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}