{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u002238f5CVUnfY5Dq4KIu82QOMgqx3APhJddBgnZYVo7WTQvE0OifMeIp43grWhUoetZ1XtgOMPwtLd7LSfSzq1pJJ9mdQO97ObRfrHDL6LFn\\\\\\\\\\\\\\\/l+SNuqW91BqovcVIUfqfuTAZKmp2Qnt7mxj7TFKpPguzoDfpw1jBYEcZBYKIMX00KRHy+mIsVwVPe8AZp4FdWt64MHqSsijRcMq9taLFBXuRBPY\\\\\\\\\\\\\\\/XL05FSuujksMgRAF60UPYCztDwRWkczhY4xu7me50Bpxb3TwXyh7ehwwW7uKYjuc9smnwMH0gkIBzN6NE6aogDyOCUgN7FVhMgHcbMC5V0eKXGgXshgzP1gkhfsvLgaGLluRBFZySt4lZdC7BjeDJOsD1UCN9q0RnsPSh+vTTKh3GC\\\\\\\\\\\\\\\/YekKRHNQueZXH7IzUcFCbxsyfwbysLJiwtdAcHXQYi5X6G5oy4jlVRxP8sHc0YDLeglIKN\\\\\\\\\\\\\\\/IRgd0k4gdkJq064rYFcrEd4teFk46RZR439zPWsuN2JQdkgK2jp5UHCY17LS\\\\\\\\\\\\\\\/pSJB0DukJk2SftQzYsblQ\\\\\\\\\\\\\\\/YHoTKiTpijjTUW6PC8SsEXnr+9CzHhkWYR4oggQB7DAiNKGt5f8sqYUvp9Ey\\\\\\\\\\\\\\\/V\\\\\\\\\\\\\\\/wbkXTYpNxwzWjGf3jMkE81sQfWzQdc9PeNMy78FQ3d\\\\\\\\\\\\\\\/yGeChxrOZH98Ozs72mglIjteOjXEVWatEfBxrNe2rq7pqqaG439WCCd0cowxf2v2r4b6HzgumGNMCVuZksI3nb8rNfU0lOjU3OhzEpyCRpVl536GvampJeiOLFxN0QiU9hOfDkqILB0kDT1gKJysNnOQQP8TIoOLIh0gVTzg1DcWmNO7C7ZcwFc0i1YU6oktpuEMkDYm+u9tmn2oVE3Y4lwUot0lOBvhxc3B2pb2hMcgUQuPbR6NevKiK8gYukjKhDV9w1B76YN5lvtSpnmOwBLtXYPKYO\\\\\\\\\\\\\\\/MUSWrgYAJ45L16+6gFSegXh9Gcht4nk8+wMPGv3R0PSmnOFInwPrxjQiKXjIU0KOXZE9SF9hDMAfxg4igps1ulus2wGyjuvSZPjSTCB\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/XcnGgoa2q\\\\\\\\\\\\\\\/UjhHwHuetCgLAtJbumooakTN62Kz69zEpaT0IqALUHiAFzT\\\\\\\\\\\\\\\/vbrOfhqECs2+jbprhz6IRrCiqrPeSHwqHP7tgzc6brqsigB+Th3WeK6fxWH08EfsYuiELK90e5dRT8PB6TMrPDTD9chZ34WB4uoaBHJwn6JolaoxOu8axFeBNjh3BV+b6Arg7mmoFqSJgs+lmpdn4c4HQScY5ZTrNQlCMCBcsLXsiWfXOiOUQmOSeK7xZ6gxCgioIOSsY\\\\\\\\\\\\\\\/VXl\\\\\\\\\\\\\\\/W80IShj\\\\\\\\\\\\\\\/EqtPwOI11ayen91eH\\\\\\\\\\\\\\\/x7+iNRw4SnqYBm6gSs7SKCpGN+2nJJ7JB9GgfxSd7ZV362WE1z4tlhjKOI\\\\\\\\\\\\\\\/eK+L72\\\\\\\\\\\\\\\/l1AGNrvl+SXh4Uo9k7JYCSeVCDjtsjj5xceLMx2muhBBEO5eqvkW0X34hM\\\\\\\\\\\\\\\/Pd1t6MfS0QF8qXGyalRhrFrEYFFQWr2wGM0DgRzcp6KpssqgQuMlgWfZLJ34+G2e5\\\\\\\\\\\\\\\/ASF19ZLMEtDr7ghHSTj5CjZlprb4Jn58YKtb585wcKMyPQrZmWUHtT0+MkwA8s90zVpWzAnbpskURHB7ZNQRoO99\\\\\\\\\\\\\\\/cVJuKMSao+CbW1JOSi2UlPG4sxNrtlkSPTidmIRTfLTUg8hffyrEdaqqYcG6m6wT8muaXKu7+f417jmKC7ClLffFphpsR264YYi7ScmxxBJqy4GnCWLm1wkZ18THSHHwpWLQjTeckE7E6fADZkFm2wuGL9Lt0eGHKvGVIYmDBGs2vH0ID68xuBJiJFnxD+NVdv3Ca0DHamsmM+RjdD5CjmUnqbf\\\\\\\\\\\\\\\/4+4ZRbAoPJFqhuitG9GrOlAi99Vhq6nKnDUkj4C5Ny8ai2m6Qapt4la3\\\\\\\\\\\\\\\/atJZweo0aUdMK+t61FXVGE0GSTC4Nto7K49k2zY4BGj8YeLoSRDqoA8zjMYzda8UrtcxyXXNpur1RjQu9I5o2Au\\\\\\\\\\\\\\\/IQxRMUryHUb0YCWi7uvdGWT6yp3fGhG+0ku8DKPjW3Iv2\\\\\\\\\\\\\\\/GG\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/LEDF\\\\\\\\\\\\\\\/Esjt7CQ99PE39mMzKktDNgVakoiJA4+jUkGCHDxLBRFERFL17BTpFbLIixODmbYZwP4y2yc+RTM1MN\\\\\\\\\\\\\\\/xQn2GDHkSelz5FnDMHncZzPDi+5KGrIKC0QS2BeBg85gPcjNVLUkah75yjxkJ5a1gVUWAKk0kgO+9r8uEVX\\\\\\\\\\\\\\\/C+B7z6U7FNyytm3vhVSHqwpKFcjHlZk9DJggLZ05vU+xO2Mfu0DeDOjPQyruZUNXxOllozH3LrbRtfhoXy1JXXTBVihmwxoIEQXmNzacj4ok4GNEgWGpiWVX2\\\\\\\\\\\\\\\/5YsyysgIctnJnXj2N3HYXGr3s+PYQB02JPF91yOlwJEBxYYo2\\\\\\\\\\\\\\\/wz30zgZDny7KT2vwaqrOdMyYpslhqD\\\\\\\\\\\\\\\/I2PfKbYgsGvYFxS6zW50iJ9VDVARO7XBmx4l3ZdjmFhFBbHCcBbHO7fiKLaOw9Dw5n6ruXZmA378xPICwoyMtCtB8a0C+89phYhRLphx5tJBKyCHOGi+CTBxXL0dr0L1J++cigxqC+BAVbhy4RnIvD6RtURuVCHSJd9PrnajsxAVoq7owKuHVQgJBcnjUBg4rsIe3GyrRs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022BThx55V8U74ILShza3IZWw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227fc8f618d2286adae46b8d0cc6ddd598878b3e6f3412c8b8a9f2f79246e3ee22\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/1\\\/e007573.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/1\\\/e007573.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007573\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007573\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007573\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}