{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u002243VHT3OP70CEWWcS1DRe5EeL+nl3JrPKCfQ4cmYtZvjX6bySKnN2KG4rRIW6RSNnkYQjlr1kZAgw91vDpTvzIPG16NXtTaQxGZtKmjbuALF1u6\\\\\\\\\\\\\\\/o7gDxoXqSGkdYShBOMwYSrexqe9Ng14Pzs8jpx8ZxgEwfTFJB5HIiTPytpuQXzZBRZeA928t8PLgVk8rxhFnvtFmZ3HVzv0XWD5KLRxV7fF\\\\\\\\\\\\\\\/w3KUoPABN0y\\\\\\\\\\\\\\\/iV6Nxg2cU\\\\\\\\\\\\\\\/lEPFaBF7cT6pWhTtOFCyqFIPyj7EKK7JxGYSIxtOVaTFX5X00DzWjHdUC896CxZfbOB9XfvjkOEX3Mx1IoIrjBvc\\\\\\\\\\\\\\\/TFQJcdVvdbRANVnKlJTQjNEt4E31dQ4aTKj1EyRxgkOur68gKvzpMiBN84g7H+uiR4l1ysdvxkVdtFLrkp3cDxRp7uN+uFoSRTbJ4BX\\\\\\\\\\\\\\\/lnX9IeHtrH4Kx1QZJnAcEFUWYx8YfjQiGWZGzt4eEh\\\\\\\\\\\\\\\/n2nNY8FqBsEcPrfhUWMytHP3Qh5EFhizlvpZ7jnc1MQn96mefn4xiFCJPQNVwZO7zjrBtUzVQgdKEEa1ClWl3pCXtHJ0p32hCJpylvY33mCbBexnCj5YvCQ9uiU\\\\\\\\\\\\\\\/hH\\\\\\\\\\\\\\\/kl7oJMKjpvLxeZjUBBkuIoj1la1z5fAKUfYD8fcvbrmfzmtqfZ7FUuLEMu5xNIIko1rcrlysbLXs\\\\\\\\\\\\\\\/2Yzc0w62YRfh0DvIbZeWRZ\\\\\\\\\\\\\\\/1xCwxEQ0Esy6Btj6EMYRIF5war5QAE\\\\\\\\\\\\\\\/bRZLMOTWCg8OvqYdSR5hB0ds1T1CHMk39RUgNOELEKxXBr9L+Ybbfxusrf4gaHpvMhqH9b2wjJm\\\\\\\\\\\\\\\/RthhCL4rtx3LbtyGElViatE2xg+iVBXOGBUGtKQFMkY4vwX7HZBLuPU1\\\\\\\\\\\\\\\/99JwY02xX0ayODpDgzB1P8uxyywPJDOsuBGriGa\\\\\\\\\\\\\\\/PmtToEzvzw0Zd9zmgvN9sa9KQvLI\\\\\\\\\\\\\\\/jmgvjbIrfag6xQ1goXQyul2EdoKl9kt5cE62F1CMG2tzIFCWCBmRa6qlnWVTwmNaz7CSHenyAvMhSm+gluiiq2Mnflp9JIzZDkz0fvK1V3LrzQei5N6E0m7d1Ophs3sDBrahQr0BD\\\\\\\\\\\\\\\/+268fjkW2BdJhreXytIYQRzd27G8OKcYneCcrNF5co9suuj7Sp1\\\\\\\\\\\\\\\/c7uMasKHoiyMjQUF\\\\\\\\\\\\\\\/9pa92jcb7wbk3iE+mR87sonAU4XzNz7I9hRj8F4h7iLbcBanMQAiIJXY9x7KJice5VPp6RLRzjvZHAC4algUdsxh3cUhfV58TZbl5qG6FdKMCBjiTsWs1D9ytPjHtvNYomEe9MdON9aOK9V4Cw9PKXIb6axMnMc5LpaWeNQWI7Gjm+X3NmvF1KaxIXNPSGoewD9Je25jC09t5+Vs81mZFOwko7XlPiC7kiT5+KOFgfSf00NfOevT+C0O5LC\\\\\\\\\\\\\\\/+GX+kkRRKFaHuFTdJpHn2cPkqXt\\\\\\\\\\\\\\\/oSoq9tMRm\\\\\\\\\\\\\\\/Xhxj\\\\\\\\\\\\\\\/x2jH5feeZzFfZP9PdxqVwFZurfl5mzXJOtImbnDZ1T8Rge0cCR0vEysstaD0CarocFOLE\\\\\\\\\\\\\\\/wghEdKHFXOGtBsqNsnz3NDzccQfxDfpyP3jFJNjQsRBVOATOBemIMKmrVO9KzuD53DHYMh3w\\\\\\\\\\\\\\\/MDI\\\\\\\\\\\\\\\/y9iLGOr8HZfLtqVOqdFTkfWKi3rYdWrsiSGn1uultIxXlQM5iBHB8SYEjP2gE3TL8psFwKTUU58uo2Gz8XgCJwTizAh6opPrXkm9n8hqLSsG0FoBWy8WDjU6qQnGpSdAqWDyIoucpBrkpvD7KrHuRIFqi7phZOIbH3Roqi5mRNRoFmsue\\\\\\\\\\\\\\\/6lrkLYznDOUOi0OFpUpwDxXyIXsZmHAntDacT6IGNjXocW1mriLx\\\\\\\\\\\\\\\/xagkXfw9z7yHTZRlHrEPDbvO\\\\\\\\\\\\\\\/cS6WsYbOIarZVvCffQN9W\\\\\\\\\\\\\\\/pz+AKoqkZOPqriwgbTLLVgkg57JT7DCeMXjdlrXIfW+T5IDMMLm6XzQHdSs4evCx+ycbF2vY3hKLlMyvjXQt2vLx0A8fWQN1mtMvdOJB4FdlLICZjGBGeL7YUjuFxquXA2FJ30cELsfw7uRoZ\\\\\\\\\\\\\\\/0avdFGnGA62fzKJVU8RvqXxHrNncUwKgpL0ZPRzkH7\\\\\\\\\\\\\\\/pND957ZG9cP2yE1WTp8oSeqzvAwO\\\\\\\\\\\\\\\/OWKskPwK1Ldzwqm8utBCQONmapTndm9N6J09lmM2kLAJzaQTGUXlHNzlrIdXLFJ8v9pnnraJTtgrF7TJ1gv52hmqZ946UTrhOjEeD9NNjH73qoHgpt20UKDwfs+pAE73VIS8DcPS6wpdPvLi85TxLNl4n3InAGG1YqKZ77R6NWFR92v8WbXgI5WCyLR59pJahpTRs3bgAqnWHQIHtNhLKk5upvM\\\\\\\\\\\\\\\/3D1lKzr6vg4iQfE30\\\\\\\\\\\\\\\/xzNjpebAbZYqqe5aQwSrd4EhyE0aDwOzcDvHxsgWO\\\\\\\\\\\\\\\/rNEKwZ\\\\\\\\\\\\\\\/YGjIy0\\\\\\\\\\\\\\\/WTwkLasW5iLlhHretuy8uzzwe5HnUCrpTgaecLDh7d9FxF7jN3hTF2\\\\\\\\\\\\\\\/cZYkVgf2AQHR1ZDSLMTComCZ\\\\\\\\\\\\\\\/MSsqcmJQbtfkuulg3+RsjbF2udryqbWwgFBNJCzJw2AOxc9Lq9es9QYqiU1K5mFGPGKE2\\\\\\\\\\\\\\\/0Sii3um7nV5N316IVUQ6uX8yPiIE62iHjjII3jwomVhCWIHP0+N692uHH39SIKkv5TpgGy8mGE6K4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022DVR5PxL8xyA6Hlb6fAToQQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022bb60ae7d992f3d4657a6b29abefd31ce61bd1a250548b53b6007435a0bae4d13\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/1\\\/e007555.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/1\\\/e007555.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007555\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007555\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007555\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}