{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022DYNms1OU6mCTSPVZUWo7wQEqr60c+ilSAwxNuMpUMXu0nDTIDMDLkV1I7ueYNnLSEXxwltK5Rf2MwYk+VSyJqCAXAzGyI5ilyU3fSoXOOSF98sWykysFyF3Nt1WVAL97\\\\\\\\\\\\\\\/Pjsiz9ZfYq7\\\\\\\\\\\\\\\/dxnwIrH4kSWVRd22c2JzScIcmAJ2m1AhNWqFYtaQqMEh8YKtHJbMCXp\\\\\\\\\\\\\\\/T1ST9BJBs5MJLPL5Ihhxz4GGr5O39UcLqcCRCIfM3zlNp87XiX0jawgi6nTXBnqU3kRCvbFWOxaQJ47uXq+P728LQTUatugU6OMJixQNIdHgtEaBBA4+jM\\\\\\\\\\\\\\\/I04ZHXbkIxpdy0ONIlRmsgF5bo4W5f9hoEmUa30nEfU0hunnmfdHUtG19BcWxX6y8UI9tFEiUUZG8Hj54LFTBerVQzAJEz2jH\\\\\\\\\\\\\\\/iN32j0UQwfBOEipmqydevZZna5\\\\\\\\\\\\\\\/m0rZjeSNjGkPHsx9hcE3ptYL+13iAhgT2e+EjEMKrCWoDSDtWNENNJilnAbwmW6GujfI9kU7vsTPw\\\\\\\\\\\\\\\/CpuniJ1PGKhLDi7jzfCyHymdRPOvvoNQBuifWoEt0WKnaTWD+VsV9k+L4AkXkR2enCtmlCmQvTjXqBQWzXTi2qkTnoYvoXW8ePC8ZZiZH8UzeuVu0IxhONEIirGTgCi4C3wCXmb1PQsSgZPd89OTjLUeCKCAH2GyGAWFbtkNEAJKEH3DsbYMyxFZOIaJAdYr3ko9Nbf1WcvfCbhbd1mfeviJPXTYqCzyUgWhm8d0ljOEizvTvldZE9kryEZhfY6FSZL31f85qGK86oedjtJtsBP6wCEmPqlN4LhPebQEEFgafzi6bzOgBpfNLzbA1KPuRgEmRnBFXFDpmb5Mr56mSyJ3R\\\\\\\\\\\\\\\/uAec9\\\\\\\\\\\\\\\/PpzhCasprds\\\\\\\\\\\\\\\/P2t+L6GQzfftrnzHUEXT4teuM8CUyMN8VC\\\\\\\\\\\\\\\/WIOcmAvLnHytxQ3JiUPvj9QMb59lFKtPS8Zv6spc4GWBXOa4nOWhWGGbxvzprVvm5oTnrNIKt1evlSMEA8IbSnke3gNyTG1k9y90zB2aCOXFc88EBwo\\\\\\\\\\\\\\\/F3ku4k3GW4vl8+nHNaCPm8t5sfFwVahOMms\\\\\\\\\\\\\\\/q+ffMLbFAwIPBDwdw+JHan8JolCEIEDMb7jmwpHFbOh6aiSqQsY3TdnlOjPeySDA\\\\\\\\\\\\\\\/J5OXQDqvJezR4MFB9VRFCnTibnTIygHgp1rV4xMQrlEgCKMbamcT8mSs8HldmQZwqGftGzqfFY\\\\\\\\\\\\\\\/2Y+3kkZ9BFPQ9SWue0bGKSptTenCaDQhwc5Gtn0OLr078NkCmNzU9RNoUM6woksp\\\\\\\\\\\\\\\/FsyFHCBBdzDQXV13Bdr5weRhIPQRe3Zp+VMfVLdxUQlaTEyDAMW8ZnlQapQhHgfNpl7J38mhkMTSXpZQhZmnsWP7nTTht1WfwzjF+aIJELbWULZZtbsllt0xMtb01t9FP4BkmL1uE3rchkJfnHWM85d\\\\\\\\\\\\\\\/H58CTpt\\\\\\\\\\\\\\\/mjlUVY94RDMHWRFc3TXP8lI09Gn7x9fep2dGDKa8IdBhrmwonbrdzuLq60BVGz0ODZRJQpPqfy0B6\\\\\\\\\\\\\\\/bnN6j+0+H+4\\\\\\\\\\\\\\\/kbtHTpLgpuWxoutXFv\\\\\\\\\\\\\\\/l0tWUF4gFXTJj535OVeQn8a4iliXy9Wysb\\\\\\\\\\\\\\\/MTEPCmxSdP30JsIU\\\\\\\\\\\\\\\/ZVNE9uR29KA\\\\\\\\\\\\\\\/W0cL67\\\\\\\\\\\\\\\/Y0l7yqjrd0CRGO3BhKIhVlsHUo1UiJHDwa0PxPhPilzDp4sH45l4R08ady8V6MSqEgE4\\\\\\\\\\\\\\\/jJFmS0u98t61t6bWN+qOgOCGd8RUv9KueK2GQ8ReufmaZNNGtGMb9amDP+9jwBZgbibxuKScBa+PZAV0V8D5xETFE9cSOOgknqTRdpcNDnWTzjh5LUa4m7sNWtOypbixISe6rOII+j9kCEPmqp1nsyOJq+RIKqSvD5d9XdrVQBp9fexR1q88DdKxZd8maTErtSGwdbJMDtgzBW5UbLJPjpHT5Rmt81yAbT8TQH2I\\\\\\\\\\\\\\\/Wo\\\\\\\\\\\\\\\/NNQ8365S11LZ3l635KGcETZ5m9DdBX1E1Yv7IITL2LSxWm7qE8qvwHY0YGFKwFZX4vE6zlXCgU+POHhODluqx\\\\\\\\\\\\\\\/pzlSCipjA5EHOVRQKV6qeJA2CVDNVKq4kfBeNbKcWF8HS7XXSLE+vyp9XCmMn4Hw8CGnneYkyUtwijFVYbKtI+JBNauC2fOLipns0pyFe5htcrODlmDfnsjC8Abh29c\\\\\\\\\\\\\\\/TP6GEjrJzvAJ51IYtKk8huaphfosuL0GtRGM84K5c7ZUAAAcZK2Tk6fQ1eewBT+F35HX3KGShBxb2qfe+tpRMCBb06SWD1n1kYbvNMjTfhovVHWw7pJAm1UfFGIQSit\\\\\\\\\\\\\\\/FQ4l1FJC89jCMf\\\\\\\\\\\\\\\/+h0JlxiY0W9sxXRh8AzFQRTDvLBPCQ2X4+AMvpSRFtcLh2GhSxut6f3tvKiK1tLoD5VFYpWXZHr7U2oo4DhpHzf\\\\\\\\\\\\\\\/7Jb5Hi7xFogfZ\\\\\\\\\\\\\\\/vqbhda+jFZkPQxVY9QdFhni7NDNJu0jQzmB3C56kNWqbxwz1Sh6WhYTEOzOQUvEC3gpZNVynVJPG91QlFinHyxkqR3B23uacOY+00xGL\\\\\\\\\\\\\\\/t3f7Jk9A3HyO3uQV8m9HVvRo6hvw1Jv+l\\\\\\\\\\\\\\\/75CiJnDO5g1afhKBkb3pmGlLJuuz6tlMj49JjzHhRNpUg9LsI2bAN\\\\\\\\\\\\\\\/i5GM\\\\\\\\\\\\\\\/nw3XuRxSzNMmF2GKXdxx8fGvbw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022j54\\\\\\\\\\\\\\\/27+ZH7665\\\\\\\\\\\\\\\/64RcWcRA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00225a183ad02643eae58fcc332e98f4ff1c607c125cd8e78619f5fd42b590084114\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P244.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P244.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;3\\\/Suppl_2\\\/P244\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-3-S2-P244\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-3-S2-P244\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-3-S2-P244\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}